Relation of Severe Deficiency of Vitamin D to Cardiovascular Mortality During Acute Coronary Syndromes

Correia, Luís Cláudio Lemos; Sodré, Fábio L.; Garcia, Guilherme; Sabino, Michael; Brito, Mariana; Kalil, Felipe; Barreto, Bruno Alexandre; Lima, Jailson Costa; Noya-Rabelo, Márcia

doi:10.1016/j.amjcard.2012.10.006

Cited by 67 publications

(55 citation statements)

References 13 publications

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“…The proper 25(OH)D level was found only in 10.6% of 216 investigated patients (110 with STEMI, 106 with unstable angina/non--STEMI). Similar results were presented by Correia et al [23]. Vitamin D sufficiency was diagnosed only in 10% of 216 patients with acute MI (7% with STEMI).…”

Section: Discussionsupporting

confidence: 77%

“…There is a lack of data concerning this relationship in patients with STEMI. Although Correia et al [23] in a comparable study have not evaluated the correlation between vitamin level and atherosclerosis severity, they have noticed the same mean value of Gensini score in patients both with severe (< 10 ng/mL) and not severe (> 10 ng/mL) vitamin D deficiency. Similar observations were reported in LURIC study [10].…”

Section: Discussionmentioning

confidence: 86%

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Vitamin D level and extent of coronary stenotic lesions in patients with first acute myocardial infarction

2013

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 86%

Vitamin D level and extent of coronary stenotic lesions in patients with first acute myocardial infarction

2013

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“…24 In another study, Correia et al reported a possible independent association between vitamin D deficiency and in-hospital cardiovascular mortality. 12 Again, in this study the sample size was relatively small (n = 206), STEMI patients were underrepresented (7% of all patients), and deaths for complications occurring after bypass surgery were also considered.…”

Section: Patient Characteristicsmentioning

confidence: 99%

“…10 Very few studies, however, have investigated the association between vitamin D levels and clinical outcomes in ACS patients thus far. [11][12][13] Therefore, convincing data demonstrating the possible impact of vitamin D insufficiency, or deficiency, on morbidity and mortality of ACS patients are still lacking. Notably, vitamin D has been demonstrated to suppress the reninangiotensin system and to affect endothelial function, inflammatory processes, platelet function, insulin resistance, and blood pressure.…”

Section: Introductionmentioning

confidence: 99%

To evaluate the role of plasma vitamin D level as a prognostic marker and its relation to in-hospital complications in patients with acute coronary syndrome

Kumar

2016

Int J Adv Med

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Background: Deficiency in 25-hydroxyvitamin D (25[OH] D), the main circulating form of vitamin D in blood, could be involved in the pathogenesis of acute coronary syndromes (ACS). To date, however, the possible prognostic relevance of 25 (OH) D deficiency in ACS patients remains poorly defined. The purpose of this study was to assess the association between 25 (OH) D levels, at hospital admission, with in-hospital complications in an unselected cohort of ACS patients. Methods: We measured 25 (OH) D in 200 ACS patients at hospital presentation. Vitamin D serum levels >30 ng/mL were considered as normal; levels between 29 and 21 ng/mL were classified as insufficiency, and levels < 20 ng/mL as deficiency. In-hospital complications were evaluated according to 25 (OH) D levels. Results: In the study population 85(42.5%) patients had normal 25 (OH) D levels, whereas 36 (18%) and 79 (39.5%) had vitamin D insufficiency and deficiency, respectively. The patients with vitamin D deficiency were associated with a higher risk for several in-hospital MACEs (major adverse clinical events) including mortality and it was statistically significant (P value < 0.05). The left ventricular function was more severely compromised in patients with vitamin D deficiency and it was statistically significant (P value < 0.05). Conclusions: In ACS patients, severe vitamin D deficiency is independently associated with poor in-hospital outcomes. Whether low vitamin D levels represent a risk marker or a risk factor in ACS remains to be elucidated.

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“…[20][21][22][23] Therefore, convincing data demonstrating the possible impact of vitamin D insufficiency or deficiency, on morbidity and mortality of ACS patients are still lacking. Notably, vitamin D has been demonstrated to suppress the reninangiotensin system and to affect endothelial function, inflammatory processes, platelet function, insulin resistance and blood pressure.…”

mentioning

confidence: 99%

Prevalence of Vitamin D Deficiency in Acute Coronary Syndrome in a Tertiary Care Hospital, Maharashtra, India

Patil¹,

Prajapati²,

Gandhi³

et al. 2017

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Relation of Severe Deficiency of Vitamin D to Cardiovascular Mortality During Acute Coronary Syndromes

Cited by 67 publications

References 13 publications

Vitamin D level and extent of coronary stenotic lesions in patients with first acute myocardial infarction

Vitamin D level and extent of coronary stenotic lesions in patients with first acute myocardial infarction

To evaluate the role of plasma vitamin D level as a prognostic marker and its relation to in-hospital complications in patients with acute coronary syndrome

Prevalence of Vitamin D Deficiency in Acute Coronary Syndrome in a Tertiary Care Hospital, Maharashtra, India

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