Relation of risk factors for cardiovascular disease to early atherosclerosis detected by ultrasonography in middle-aged normotensive hypercholesterolemic men

Giral, Philippe; Filitti, V.; Levenson, Jaime; Pithois-Merli, I.; Plainfossé, M. C.; C, Mainardi; Gold, Alain; Simon, Alain

doi:10.1016/0021-9150(90)90106-s

Cited by 39 publications

(15 citation statements)

References 19 publications

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“…The early detection of atherosclerosis, before ischaemic vascular complications develop, is a major step in the assessment of human hypercholesterolaemia. Ultrasound techniques permit the detection of atherosclerotic plaques, a relatively late feature in the process of atherosclerosis [5]. However, early in the development of atherosclerosis, functional disturbances occur at the site of the endothelium [6].…”

Section: Introductionmentioning

confidence: 99%

Does lowering of cholesterol levels influence functional properties of large arteries?

Kool

Boudier

Bortel

et al. 1995

Eur J Clin Pharmacol

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Hypercholesterolaemia is a risk factor for atherosclerosis and induces endothelial dysfunction. Endothelial dysfunction may increase vascular tone and arterial stiffness and as a consequence may decrease arterial distensibility (DC) and arterial compliance (CC). It is hypothesized that lipid-lowering therapy may enhance DC and CC. Therefore, the present study investigates the effect of lipid-lowering therapy with pravastatin on the haemodynamics, DC and CC of the elastic common carotid artery (CCA), and the muscular femoral (FA) and brachial (BA) arteries in patients with primary hypercholesterolaemia. After an 8-week placebo run-in period with a low-cholesterol diet, 19 patients with total cholesterol concentrations of between 6.5 and 9.0 mmol.l-1 and triglyceride concentrations < 4 mmol.l-1 entered a double-blind placebo controlled crossover study. Patients received pravastatin 40 mg o.d. or placebo, each for 8 weeks. Throughout the study the lipid-lowering diet was continued. With pravastatin, total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglycerides were decreased (total cholesterol 26%, LDL-C 35%, triglycerides 16%), while high-density lipoprotein cholesterol (HDL-C) was not changed. Other laboratory values remained within the normal range. Blood pressure, heart rate, cardiac function and systemic vascular resistance were not influenced by pravastatin. Compared to placebo, diameter, distensibility and compliance of all arteries were not statistically significantly changed with pravastatin. These data suggest that, in patients with mild to moderate primary hypercholesterolaemia, short-term lowering of plasma cholesterol does not alter the haemodynamics and vessel wall properties of large arteries.

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Section: Introductionmentioning

confidence: 99%

Does lowering of cholesterol levels influence functional properties of large arteries?

Kool

Boudier

Bortel

et al. 1995

Eur J Clin Pharmacol

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“…[25][26][27][28] The available data on carotid artery damage have shown that in women, atherosclerotic lesions often seem correlated with age. 4,5,29,30 It has been demonstrated that the incidence of coronary ischemic disease is correlated with carotid artery IMT; hence IMT is a predictive marker of coronary and carotid vascular events. 10,[31][32][33] Consequently, we would like to stress our US findings showing a high prevalence in female population of IMT over a value of initial evidence of atherosclerotic damage to the carotid arteries.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] Detection of early changes in the carotid artery wall intima and media is a benchmark for probability studies on subjects who may develop atherosclerosis of the extracranial carotids. [4][5][6][7] Increased intima-media thickness (IMT) is one of the most sensitive markers of cardiac and vascular diseases and is the focal point of studies aimed at preventing vascular disease and reducing vascular events. [7][8][9][10][11][12][13] Various diseases (eg, arterial hypertension, dyslipidemia, diabetes mellitus), overweight, and lifestyle factors (eg, smoking, occupation, sedentary lifestyle, and diet) play major roles in the development and progression of IMT and atherosclerotic plaque.…”

mentioning

confidence: 99%

Early Carotid Atherosclerosis in Women: Results of an Ultrasonographic Study Measuring Carotid Artery Intima-Media Thickness

Signorelli¹,

Costa²,

Digrandi³

et al. 2005

Journal of Stroke and Cerebrovascular Diseases

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“…Evidence regarding the independent influence of the first three factors on aortic atherosclerosis can be found in the literature. Age is a wellknown predictor of the development of atherosclerosis on the whole [18][19][20] and aortic atherosclerosis in part [21][22][23][24] . There are also some data in the literature showing that smoking is independently connected with both the development and progression of aortic atherosclerosis [25][26][27][28] .…”

Section: Discussionmentioning

confidence: 99%

Aortic Atheromas in Acute Ischemic Stroke Patients in Northern Israel

Telman

Kouperberg

Sprecher

et al. 2012

JAT

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Aim: There are currently no data on ethnic differences in aortic atherosclerosis in Arab and Jewish patients from northern Israel with acute ischemic stroke. Methods: Data on demographic and risk factors alongside transesophageal echocardiography (TEE) data and treatment details for 509 patients with acute ischemic stroke were included in the study. Results:The patients with aortic atheromas were older and had significantly more frequent vascular risk factors (hypertension, hyperlipidemia, and smoking), as well as vascular disease (ischemic heart disease, peripheral vascular disease, and carotid plaques). They were also treated with statins more often than those without aortic atheroma. Logistic regression analysis showed that age, smoking, ethnicity, and the presence of carotid plaques were independent predictors for aortic atheromas. Aortic plaques were found more frequently in Jewish patients than Arab patients (160 (41.9%) vs. 35 (27.3%); p 0.003). This finding did not change after adjustment for age, sex, all vascular risk factors, and type of antithrombotic treatment. We did not find any difference between Arab and Jewish patients in the distribution of plaques by location or complexity before and after adjustment for age, sex, all vascular risk factors, or type of antithrombotic or lipid-lowering treatment. Conclusions: Our findings emphasize the influence of ethnicity on the prevalence of aortic atheromas in acute ischemic stroke patients in northern Israel. The search for genetic, cultural, socioeconomic, and other factors explaining these ethnic differences should be the topic of future studies.

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Relation of risk factors for cardiovascular disease to early atherosclerosis detected by ultrasonography in middle-aged normotensive hypercholesterolemic men

Cited by 39 publications

References 19 publications

Does lowering of cholesterol levels influence functional properties of large arteries?

Does lowering of cholesterol levels influence functional properties of large arteries?

Early Carotid Atherosclerosis in Women: Results of an Ultrasonographic Study Measuring Carotid Artery Intima-Media Thickness

Aortic Atheromas in Acute Ischemic Stroke Patients in Northern Israel

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