Relation of reproductive disturbance in sheep and Leptospira interrogans serovar Icterohaemorrhagiae infection: Impacts on cellular oxidation status

Silva, Aleksandro S. Da; Souza, Carine F.; Baldissera, Matheus D.; Laer, Ana Eucares von; Lovato, Luciane Teresinha; Sarturi, Janine Alves; Herrmann, Geder Paulo; Moura, Anderson Barbosa de; Favaretto, Jorge A.; Frias-De-Diego, Alba; Machado, Gustavo

doi:10.1016/j.micpath.2019.02.029

Cited by 7 publications

(10 citation statements)

References 37 publications

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“…A possible explanation for this increased activity might be because cells of the immune system are attempting to neutralize the damage caused by the overproduction of free radicals. In 2019, Da Silva et al published a paper in which they described the effect of Brucella abortus and L. interrogans seropositivity on oxidative stress in ewes with reproductive disturbances 13 . Compared with our findings, Da Silva’s study confirmed increases in serum GPx activities in animals infected with leptospirosis 13 .…”

Section: Discussionsupporting

confidence: 73%

“…In 2019, Da Silva et al published a paper in which they described the effect of Brucella abortus and L. interrogans seropositivity on oxidative stress in ewes with reproductive disturbances 13 . Compared with our findings, Da Silva’s study confirmed increases in serum GPx activities in animals infected with leptospirosis 13 . It is also possible that the increases in GPx activity were due to adaptions by the body in response to oxidative conditions following infection with Leptospira bacteria 38 .…”

Section: Discussionsupporting

confidence: 69%

“…To our knowledge, little is known about changes in oxidative stress parameters and APRs in animals with subclinical and asymptomatic infections, for which most information is contradictory and improbable. Nevertheless, several published studies have demonstrated the importance of ROS production during leptospiral infection in humans and animals 13,19‐21 . The aim of this study was to add to these debates by examining oxidative stress profiles and APP concentrations in horses and cattle with natural leptospiral infections.…”

Section: Introductionmentioning

confidence: 99%

“…Oxidants are unstable molecules that can damage all biological molecules and cause severe sequela, including genetic mutations, cancer, and cellular apoptosis or necrosis 11 . The most important oxidants in mammalian bodies are reactive oxygen species (ROS) and reactive nitrogen species 4,12‐15 . Oxidative processes are important because they can control free radical production.…”

Section: Introductionmentioning

confidence: 99%

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The effect of natural infection with differentLeptospira interrogansserovars on oxidative stress biomarkers and acute‐phase responses in horses and cattle

Niroomandi

Maleki

Abdollahpour

et al. 2022

Veterinary Clinical Pathol

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Leptospirosis is one of the important zoonotic bacterial diseases with a worldwide distribution that is often subclinical. We aimed to investigate the oxidant/antioxidant balance and acute‐phase response in naturally infected horses and cattle with Leptospira interrogans. A total of 600 serum samples from horses and cattle were examined for L. interrogans antibodies using the microscopic agglutination test to determine anti‐Leptospira IgG antibodies against a panel of eight important Leptospira antigens in Iran. Then, serum total antioxidant capacity, catalase, glutathione peroxidase, and malondialdehyde activities, and nitric oxide, total protein, serum amyloid A, haptoglobin, and albumin concentrations were measured in seropositive and seronegative samples. Serum catalase activities and malondialdehyde, serum amyloid A, and haptoglobin ‌concentrations in seropositive cattle and horses were significantly higher (P < .05) than in those that were seronegative. Antibody titers increased from 1:100 to ≥1:200 in cattle with L. interrogans infection, resulting in a decrease in the serum total antioxidant capacity (P < .05), an increase in serum glutathione peroxidase (P < .01) activity and nitric oxide (P < .05) , serum amyloid A (P < .01), and haptoglobin (P < .05) concentrations. Following the increase in the agglutinating antibody titers in horses infected with L. interrogans, the serum total antioxidant capacity (P < .01) decreased, and serum nitric oxide (P < .05), malondialdehyde (P < .05), and serum amyloid A (P < .01) concentrations were increased. In this study, horses and cattle had extensive changes in oxidant/antioxidant equilibrium and acute‐phase protein concentrations when infected with L. interrogans. We also demonstrated a direct link between antibody titers and the type of leptospiral serovar using serum oxidative and inflammatory markers.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionsupporting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The effect of natural infection with differentLeptospira interrogansserovars on oxidative stress biomarkers and acute‐phase responses in horses and cattle

Niroomandi

Maleki

Abdollahpour

et al. 2022

Veterinary Clinical Pathol

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“…Generally, leptospirosis is related to reproductive disorders, such as abortion, return to estrus and stillborn lambs. It also decreases productivity, which results in great economic losses (LILENBAUM et al, 2009;HIGINO;AZEVEDO, 2014;SILVA et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of response to anti-leptospira bacterin vaccination in pregnant ewes and the passive transfer of antibodies to their offspring

et al. 2020

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Leptospirosis in sheep is often underestimated, and leads to great economic losses for the sheep farming industry. The aim of this study was to evaluate the humoral immune response in pregnant ewes, after the injection of a commercial polyvalent vaccine for leptospirosis, and to observe the transmission of anti-Leptospira antibodies through the colostrum to the offspring. For this, 24 pregnant ewes were vaccinated for leptospirosis. Blood samples were collected prior to vaccination and then 7, 14, 21, 28, 35, 42 and 49 days after vaccination. In order to evaluate passive immunity transfer, blood samples of 32 lambs were collected during the first 48 hours after birth, and another collection was performed 10 to 21 days after birth. The lambs were placed into 2 groups: Group A (n=16): singleton lambs; and group B (n=16): twins. The sera samples were submitted to the Microscopic Agglutination Test (MAT), in which 21 Leptospira serovars were tested. The results were analyzed in a descriptive form. The number of sheep reactive to MAT gradually increased until 21 days after vaccination, and decreased right after. Of all the serovars contained in the vaccine, the largest proportion of animals were seroconverted to Hardjoprajtino serovar, Serjoe serogroup. Anti-Leptospira antibodies transferred through colostrum to lambs were detected by MAT in the serum collected 24-48 hours after birth. It was observed that 65.6% (21 out of 32) of the lambs were reactive. In the subsequent collections that occurred from 10 to 21 days after birth, a decrease in the number of animals reactive to the MAT was detected. There was no significant statistical difference for the passive transfer of antibodies between single or twin lambs.

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Use of serological and molecular techniques for detection of Leptospira sp. carrier sheep under semiarid conditions and the importance of genital transmission route

Nogueira¹,

Costa²,

Bezerra³

et al. 2020

Acta Tropica

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Relation of reproductive disturbance in sheep and Leptospira interrogans serovar Icterohaemorrhagiae infection: Impacts on cellular oxidation status

Cited by 7 publications

References 37 publications

The effect of natural infection with differentLeptospira interrogansserovars on oxidative stress biomarkers and acute‐phase responses in horses and cattle

The effect of natural infection with differentLeptospira interrogansserovars on oxidative stress biomarkers and acute‐phase responses in horses and cattle

Evaluation of response to anti-leptospira bacterin vaccination in pregnant ewes and the passive transfer of antibodies to their offspring

Use of serological and molecular techniques for detection of Leptospira sp. carrier sheep under semiarid conditions and the importance of genital transmission route

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