Relation of Red Cell Distribution Width With CHA2DS2-VASc Score in Patients With Nonvalvular Atrial Fibrillation

Kurt, Mustafa; Tanboğa, İbrahi̇m Hali̇l; Büyükkaya, Eyüp; Karakaş, Mehmet; Akçay, Adnan Burak; Şen, Nihat

doi:10.1177/1076029613478157

Cited by 23 publications

(23 citation statements)

References 31 publications

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“…9,11,12 Many studies have shown a correlation between higher RDW values and prognosis, but these studies were about cardiovascular and cerebrovascular diseases, chronic renal failure, liver disease, pancreatitis and venous thromboembolism. [13][14][15][16][17] Kurt et al showed a correlation of nonvalvular atrial fibrillation and higher RDW values in 320 patients. 13 Demir et al conducted a study of 37 patients with cerebral sinus thrombosis and 101 patients with primary headache with a total of 138 patients.…”

Section: Discussionmentioning

confidence: 99%

“…[13][14][15][16][17] Kurt et al showed a correlation of nonvalvular atrial fibrillation and higher RDW values in 320 patients. 13 Demir et al conducted a study of 37 patients with cerebral sinus thrombosis and 101 patients with primary headache with a total of 138 patients. In that study, increased RDW values were correlated with the existence of vertebral sinus thrombosis.…”

Section: Discussionmentioning

confidence: 99%

“…17 RDW is used to show the severity and prognosis of various diseases, and has been found to have the above-mentioned qualities. [13][14][15][16][17] Wang et al showed higher mortality rates with RDW values > 13.4%. 17 In our study, we found sensitivity of 88.2% and specificity of 91.8%, with a cut-off value of 14.35% in ROC analysis.…”

Section: Discussionmentioning

confidence: 99%

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New predictor of acute necrotizing pancreatitis: Red cell distribution width

Yalçın¹,

Taş²,

Kara³

et al. 2018

Adv Clin Exp Med

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Background. Acute pancreatitis (AP) is inflammation of the pancreas of various severity ranging from mild abdominal pain to mortality. AP may be classified as acute interstitial edematous pancreatitis (AEP) or acute necrotizing pancreatitis (ANP), according to the revised Atlanta criteria. Most of the patients with AP are AEP (75-85% of patients), while 15-25% of patients have ANP. The mortality rate is 3% in AEP and 15% in ANP. Thus, it is important to predict the severity of AP to decrease the morbidity and mortality.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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New predictor of acute necrotizing pancreatitis: Red cell distribution width

Yalçın¹,

Taş²,

Kara³

et al. 2018

Adv Clin Exp Med

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“…Recently, a series of clinical experiments have revealed that an increased RDW is an independent predictive factor of poor prognosis for cardiovascular diseases, such as cardiac failure, coronary heart disease and AF [21,22,23,24,25,26]. Kurt et al [14] discovered that high RDW is an independent predictive factor for a high CHA 2 DS 2 -VASc score, while Lee et al [13] found that the CHA 2 DS 2 -VASc score and the occurrence rate of ischemic stroke increase with an increase in RDW. It can be seen that high RDW is associated with an increased risk of AF embolism.…”

Section: Discussionmentioning

confidence: 99%

“…Some factors, such as age, hypertension and stroke, can be treated as predictors for evaluating the risks of thromboembolism and bleeding in patients with AF [2]. There has been research reporting that RDW can serve as an index to evaluate the risk of thromboembolism in patients with AF [14]; however, studies regarding the correlation between RDW and bleeding risk in patients with AF are lacking at present. Therefore, this research aimed to probe into the possibility of treating RDW as a reference index to evaluate the bleeding risk in nonvalvular AF (NVAF) patients who take dabigatran after catheter ablation.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of Red Blood Cell Distribution Width on Bleeding Events in Nonvalvular Atrial Fibrillation Patients Taking Dabigatran (110 mg b.i.d.) after Catheter Ablation

et al. 2016

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Objectives: Recent research has indicated that red blood cell distribution width (RDW) is associated with the prognosis of cardiovascular diseases such as chronic heart failure and coronary heart disease. We aimed to study the predictive value of RDW for bleeding events in patients with nonvalvular atrial fibrillation (NVAF) during the administration of 110 mg of dabigatran twice a day after catheter ablation. Methods: One hundred and seventy-two NVAF patients who were hospitalized and received catheter ablation in Jiangsu Provincial People's Hospital from January 2014 to January 2015 were enrolled (110 mg of dabigatran was administered orally to outpatients preoperatively twice a day for 3 weeks). The enrolled patients were divided into the high RDW (>12.8%) group (n = 85) and the low RDW (≤12.8%) group (n = 87) according to the median RDW. The activated partial thromboplastin time (APTT) at dabigatran trough concentration was also detected. Patients were followed up for 3 months to observe the occurrence of bleeding events, and the predictive value of RDW as well as APTT for bleeding events was assessed from receiver-operating characteristic (ROC) analyses. Results: In all patients, preoperatively, no bleeding events were observed and the APTT did not exceed twice the normal upper limit. Thirteen cases of bleeding events, all minor bleeding, occurred after a 3-month follow-up: 3 of gingival bleeding, 3 of urinary tract bleeding, 3 conjunctival hemorrhages and 4 subcutaneous hemorrhages. The incidence of bleeding events in the low RDW group was lower than in the high RDW group (3.4 vs. 11.8%, p = 0.039). The areas under the ROC curve for RDW and APTT to predict the occurrence of bleeding events were 0.737 (cutoff point 13.25%; p < 0.05) and 0.558 (p > 0.05), respectively. Conclusion: RDW was associated with the occurrence of bleeding events in NVAF patients on dabigatran (110 mg twice a day) after ablation, while also being an independent predictor of bleeding events. RDW had superior predictive value for bleeding events over APTT when APTT did not exceed twice the normal upper limit.

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