“…In contrast to the literature concerning amyloid plaques, a large number of studies have arrived at a common finding, namely, there is a strong link between neocortical NFTs and cognitive decline (Tomlinson et al, 1970; Duyckaerts et al, 1990, 1997, 1998; Mckee et al, 1991; Arriagada et al, 1992; Bierer et al, 1995; Davis et al, 1995; Dickson et al, 1995; Nagy et al, 1995, 1999; Cummings et al, 1996; Berg et al, 1998; Grober et al, 1999; Sabbagh et al, 1999; Gold et al, 2000; Mungas et al, 2001; Riley et al, 2002; Silver et al, 2002; Tiraboschi et al, 2002; Guillozet et al, 2003; Bennett et al, 2004; Kraybill et al, 2005; Holtzer et al, 2006; Markesbery et al, 2006; Koepsell et al, 2008; Whitwell et al, 2008; Beach et al, 2009; Brayne et al, 2009; Giannakopoulos et al, 2009; Sabbagh et al, 2010; Robinson et al, 2011). It should be noted that outside of frontotemporal lobar degeneration (FTLD), one does not see widespread cortical NFTs without abundant plaque pathology.…”