Relation of quantitative flow ratio with transit time coronary artery bypass graft flow measurement

Abstract

BackgroundQuantitative flow ratio (QFR) is a new functional index to assess the functional significance of coronary stenosis. While whether there is an association between QFR and transit-time flow measurement (TTFM) parameters of the target coronary artery has not been well addressed.MethodsA total of 89 patients receiving the in situ left internal thoracic artery (LITA) grafts to the left anterior descending artery (LAD), and 19 patients undergoing the saphenous vein grafts (SVG) were enrolled in this retrospective study. The QFR value of the LAD was evaluated preoperatively. According to the QFR values, patients with the LITA to the LAD bypass grafts were divided into two groups (group A1: QFR < 0.75, group A2: QFR ≥ 0.75), and SVG patients were divided into two groups (V1 group: QFR < 0.75, V2 group: QFR ≥ 0.75).ResultsIn groups A1 and A2, respectively, median graft flow (Qm) was 44 (34) mL/minute and 26.5 (30.0) ml/minute; median pulsatility index (PI) was 2.00 (1.00) and 2.65 (0.90). Significant differences were observed in Qm (P = 0.034) and PI (P = 0.030). And the correlation coefficients of the TTFM variables with QFR were Qm: r = r = −0.226, (P = 0.036), PI: r = 0.265 (P = 0.012) among the LITA to LAD population.ConclusionTTFM variables, especially the PI, of the LITA in situ graft to the LAD during Coronary artery bypass grafting (CABG) are strongly affected by preoperative QFR values. Moreover, in functionally mild coronary stenosis, the chance of competitive flow increases.

Preoperative Quantitative Flow Ratio, Intraoperative Transit Time Flow Measurement Parameters, and Their Predictive Value for Short-Term Graft Failure After Coronary Artery Bypass Grafting

“…17 The correlation coefficients between preoperative QFR and the TTFM parameters (Qm and PI) in patients who underwent LIMA-LAD were −0.226 (P=0.036) and 0.265 (P=0.012), respectively. 17 In contrast to that study, 17 the present study included a comprehensive cohort of 510 patients who underwent IMA-LAD, with 93.1% receiving a LIMA graft and 6.9% receiving a RIMA graft. Notably, our sample size was approximately 6-fold larger than that of Chen et al 17 Furthermore, we conducted subgroup analyses based on different graft vessels and found that the preoperative QFR remained significantly correlated with TTFM parameters regardless of whether the graft vessel was the LIMA or the RIMA.…”

“…5 Chen et al explored the association between QFR and TTFM parameters in 2022. 17 That study included 89 patients, 77 of whom underwent LIMA-LAD and 12 patients who received a saphenous vein graft (SVG). 17 The correlation coefficients between preoperative QFR and the TTFM parameters (Qm and PI) in patients who underwent LIMA-LAD were −0.226 (P=0.036) and 0.265 (P=0.012), respectively.…”

“…17 That study included 89 patients, 77 of whom underwent LIMA-LAD and 12 patients who received a saphenous vein graft (SVG). 17 The correlation coefficients between preoperative QFR and the TTFM parameters (Qm and PI) in patients who underwent LIMA-LAD were −0.226 (P=0.036) and 0.265 (P=0.012), respectively. 17 In contrast to that study, 17 the present study included a comprehensive cohort of 510 patients who underwent IMA-LAD, with 93.1% receiving a LIMA graft and 6.9% receiving a RIMA graft.…”

“…17 In contrast to that study, 17 the present study included a comprehensive cohort of 510 patients who underwent IMA-LAD, with 93.1% receiving a LIMA graft and 6.9% receiving a RIMA graft. Notably, our sample size was approximately 6-fold larger than that of Chen et al 17 Furthermore, we conducted subgroup analyses based on different graft vessels and found that the preoperative QFR remained significantly correlated with TTFM parameters regardless of whether the graft vessel was the LIMA or the RIMA. In addition, compared with LIMA-LAD, the correlations between QFR and TTFM parameters were stronger for the RIMA graft.…”

Effects of coronary artery disease in patients with permanent left bundle branch area pacing: A retrospective study

“…The diagnosis of CAD hinged on the identification of a stenotic lesion, with a degree of at least 70% ascertained via visual angiographic assessment, in either the major arteries or their epicardial branches [ [28] , [29] , [30] , [31] ]. In sensitivity analyses, QFR ≤0.75 for major arteries or their epicardial branches was used as the diagnostic standard for CAD [ 32 , 33 ].…”