Relation of Procollagen Type III Amino Terminal Propeptide Level to Sepsis Severity in Pediatrics

Saleh, Nagwan Y.; Aboelghar, Hesham M.; Salem, Sherif S.; Soliman, Shimaa E.; Elian, Doaa M.

doi:10.3390/children8090791

Cited by 2 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Levels of ICTP and procollagen were also higher in non-survivors compared to survivors [ 70 ]. Increased levels of ICTP were also found in patients with Gram-negative sepsis [ 71 ], and increased procollagen III levels were found in other studies in septic patients [ 72 , 73 ]. Procollagen III is also increased during ARDS, and might be an important contributor to the progression to fibrosis [ 74 ].…”

Section: Extracellular Matrix Alterationmentioning

confidence: 72%

Role of the interstitium during septic shock: a key to the understanding of fluid dynamics?

Dargent,

Dumargne,

Labruyère

et al. 2023

j intensive care

View full text Add to dashboard Cite

Background While not traditionally included in the conceptual understanding of circulation, the interstitium plays a critical role in maintaining fluid homeostasis. Fluid balance regulation is a critical aspect of septic shock, with a well-known association between fluid balance and outcome. The regulation of transcapillary flow is the first key to understand fluid homeostasis during sepsis. Main text Capillary permeability is increased during sepsis, and was classically considered to be necessary and sufficient to explain the increase of capillary filtration during inflammation. However, on the other side of the endothelial wall, the interstitium may play an even greater role to drive capillary leak. Indeed, the interstitial extracellular matrix forms a complex gel-like structure embedded in a collagen skeleton, and has the ability to directly attract intravascular fluid by decreasing its hydrostatic pressure. Thus, interstitium is not a mere passive reservoir, as was long thought, but is probably major determinant of fluid balance regulation during sepsis. Up to this date though, the role of the interstitium during sepsis and septic shock has been largely overlooked. A comprehensive vision of the interstitium may enlight our understanding of septic shock pathophysiology. Overall, we have identified five potential intersections between septic shock pathophysiology and the interstitium: 1. increase of oedema formation, interacting with organ function and metabolites diffusion; 2. interstitial pressure regulation, increasing transcapillary flow; 3. alteration of the extracellular matrix; 4. interstitial secretion of inflammatory mediators; 5. decrease of lymphatic outflow. Conclusions We aimed at reviewing the literature and summarizing the current knowledge along these specific axes, as well as methodological aspects related to interstitium exploration.

show abstract