Relation of plasma adiponectin levels and aortic stiffness after acute ST-segment elevation myocardial infarction

Abstract

Background: Pulse wave velocity is a measure of aortic stiffness and an independent predictor of cardiovascular morbidity and mortality. Adiponectin is involved in atherosclerosis and inflammation. In the present study we aimed to explore the association between plasma adiponectin concentrations and pulse wave velocity in the acute phase after STsegment elevation myocardial infarction (STEMI). Methods: Forty-six consecutive STEMI patients (mean age 57±11 years) treated with primary percutaneous coronary intervention (PCI) were enrolled in this cross-sectional study. Plasma adiponectin was measured 2 days after index event by enzyme-linked immunosorbent assay. Aortic pulse wave velocity (PWV) was calculated by the transit-time method with the use of a velocity-encoded, phase-contrast cardiac magnetic resonance protocol. Results: Median plasma adiponectin concentration was 2385 ng/ml (interquartile range 1735-5403). Males had lower plasma adiponectin values than females and current smokers had lower values than non-smokers (all p<0.02). Adiponectin was significantly associated with PWV (r=0.505, p<0.001), age (r=0.437, p=0.002), and total cholesterol (r=0.468, p=0.001). Multiple linear regression analysis revealed adiponectin as a predictor of PWV independently of age, sex, smoking status, total cholesterol, and N-terminal pro-B-type natriuretic peptide (p=0.027). Conclusions: Plasma adiponectin concentrations are strongly associated with aortic stiffness in patients after acute STEMI treated with primary PCI. Our data support a possible role for adiponectin as an independent risk marker for increased aortic stiffness in STEMI patients.

High-sensitivity troponin T for prediction of left ventricular function and infarct size one year following ST-elevation myocardial infarction

“…The 10% coefficient of variation value is 13 ng/L. CK and LDH activities as well as hs-CRP concentrations were measured by routine assays (Roche Diagnostics®, Vienna, Austria) as described previously [18,23].…”

Aortic stiffness is associated with elevated high-sensitivity cardiac troponin T concentrations at a chronic stage after ST-segment elevation myocardial infarction

“…Evaluation was performed using standard software (ARGUS; Siemens) as described in detail previously [5,7]. Aortic PWV was assessed by the transit-time method, the PWV being calculated as the ratio of distance between the ascending and abdominal aorta and the time difference between the arrivals of the pulse wave at these levels.…”

“…Determination of aortic pulse wave velocity (PWV) provides the best functional surrogate of aortic stiffness [6]. Phase-contrast cardiac magnetic resonance (CMR) represents a non-invasive, accurate and reproducible method for the determination of aortic PWV [7].…”

Złamania niskoenergetyczne — nowe powikłanie cukrzycy typu 2?

“…Adiponektyna jest hormonem regulującym wrażliwość na insulinę oraz mającym działanie przeciwzapalne. Udowodniono, że jej niskie stężenia w surowicy współistnieją z licznymi patologiami -cukrzycą typu 2 oraz jawną klinicznie miażdżycą, w tym z zawałem serca [55,56]. Jej stężenia w surowicy odwrotnie korelują z zawartością tkanki tłuszczowej -u osób otyłych stwierdza się hipoadiponektynemię [57].…”