Relation of Neutrophil to Lymphocyte Ratio With Periprocedural Myocardial Damage in Patients Undergoing Elective Percutaneous Coronary Intervention

Bressi, Edoardo; Mangiacapra, Fabio; Ricottini, Elisabetta; Cavallari, Ilaria; Colaiori, Iginio; Gioia, Giuseppe Di; Creta, António; Sciascio, Germano Di

doi:10.1016/j.amjcard.2016.07.015

Cited by 12 publications

(16 citation statements)

References 18 publications

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“…13 Herein, we established that NLR of patients following PCI exhibited dynamic changes over time. These results are consistent with the report by Bressi et al 14 In their study, NLR values were monitored at 6 and 24 hours after PCI, and they found that NLR significantly increased at 6 and 24 hours after PCI, with mean NLR We also found that postoperative NLR (within 24 hours) was significantly higher than preoperative NLR. Postoperative NLR (within 24 hours) in the MACE and non-MACE groups were 5.97 (AE3.03) and 4.37 (AE2.36), respectively.…”

Section: Discussionsupporting

confidence: 92%

Correlation of neutrophil-to-lymphocyte ratio with the prognosis of non-ST-segment elevation in patients with acute coronary syndrome undergoing selective percutaneous coronary intervention

Wang

Cao

et al. 2020

J Int Med Res

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Objective We aimed to explore the relationship between neutrophil-to-lymphocyte ratio (NLR) at three timepoints and prognosis of patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) undergoing elective percutaneous coronary intervention (PCI) within 1 year of PCI. Methods This retrospective study enrolled 231 patients with NSTE-ACS who received PCI and were followed for 1 year after PCI. The study population was divided into major adverse cardiovascular and cerebrovascular events (MACE) and non-MACE groups. Results In total, 214 patients completed the 1-year follow-up; 32 patients (15.0%) had MACE and 182 (85.0%) had no MACE. The MACE and non-MACE groups differed significantly in age, preoperative neutrophil count, preoperative and postoperative NLR, proportion of three-vessel lesion disease, preoperative lymphocyte count, postoperative lymphocyte count within 24 hours, postoperative lymphocyte count over 24 hours, and left ventricular ejection fraction (LVEF). Multivariate logistic regression analysis showed that preoperative NLR, postoperative NLR within 24 hours, age, and LVEF values were independent risk factors for MACE in patients with NSTE-ACS after elective PCI. Conclusion Compared with preoperative NLR, postoperative NLR (within 24 hours) may have a stronger ability to predict the occurrence of MACE in NSTE-ACS patients within 1 year after elective PCI.

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Section: Discussionsupporting

confidence: 92%

Correlation of neutrophil-to-lymphocyte ratio with the prognosis of non-ST-segment elevation in patients with acute coronary syndrome undergoing selective percutaneous coronary intervention

Wang

Cao

et al. 2020

J Int Med Res

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“…5 NLR seems to have a prognostic role in patients with and without cardiac diseases. 13 Our findings suggest that patients undergoing knee arthroplasty with tourniquet application have a lesser extension of inflammation according to lower postoperative values of NLR. This finding is consistent with a previous study of Barker and colleagues 14 in which the increase of NLR was not modulated by tourniquet use during TKA and our study with a larger sample of patients shows an even better difference between the groups treated with and without tourniquet.…”

Section: Discussionmentioning

confidence: 50%

Impact of Tourniquet Use on Systemic Inflammatory Parameters, Functional Physical Recovery, and Cardiovascular Outcomes of Patients Undergoing Knee Arthroplasty: A Case-Control Study

et al. 2019

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AbstractThe benefits of tourniquet use during orthopaedic surgery are controversial. We aim to investigate its effects on systemic inflammation, functional physical recovery, and cardiovascular complications of patients undergoing knee arthroplasty. We enrolled 129 consecutive patients (57 treated with tourniquet vs. 72 in the control group) undergoing total unilateral knee arthroplasty, followed by inpatient rehabilitation protocol at our institution. Blood samples were drawn in all patients at baseline and within 24 hours after surgery for complete blood cell count assessment. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were calculated as the ratio between the absolute number of neutrophil and platelets over the absolute number of lymphocytes, respectively. The numeric rating scale (NRS; 0–10) assessed the current pain, day after the surgery. All subjects underwent physical functional evaluation measured by the modified Barthel's index (MBI) at the end of the rehabilitation. We also recorded the incidence of major bleeding, typical angina, and occurrence of atrial fibrillation after surgery. In the overall population, a significant postprocedural increase in NLR and PLR was observed (p < 0.001). Baseline NLR and PLR were similar in patients with and without tourniquet (1.5 ± 0.8 vs. 1.95 ± 1.2, p = 0.081; 120 ± 42 vs. 131 ± 55, p = 0.240); however, patients treated with tourniquet showed significantly lower NLR at 24 hours (6.1 ± 3.6 vs. 8.1 ± 5.7, p = 0.043). NRS scores were significantly higher in the tourniquet group without compromising functional and physical recovery whereas no significant differences were appreciated in MBI scores between the two groups. Moreover, the rates of postoperative atrial fibrillation (1 [2%] vs. 9 [12%], p = 0.042) and major bleeding (2 [4%] vs. 11 [15%], p = 0.038) were significantly lower in the tourniquet group. Tourniquet seems a useful tool which is able to mitigate the inflammatory activation and prevent the occurrence of atrial fibrillation and major bleeding without altering functional physical recovery of patients undergoing total knee arthroplasty.

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“…Nuestros resultados indican una asociación significativa entre los niveles aumentados de INL mayores de 6 después del proceder y la presencia de trombosis temprana del stent, con una sensibilidad y especificidad alta. Resultados similares encontraron Burak A et al 16 , que demostraron que un INL mayor de 4,9 tiene alta sensibilidad y especificidad en la predicción de mortalidad intrahospitalaria y relación significativa con la presencia de TS. De manera independiente, el conteo de neutrófilos a las 6 horas del proceder se asoció a la presencia de trombosis del stent TABLA 1.…”

Section: Discussionunclassified

“…Este biomarcador INL, de fácil determinación, disponible, reproducible y económico, emerge como marcador del estado inflamatorio. En este sentido, existen antecedentes que relacionan el INL con la TS y la alta mortalidad en pacientes con síndrome coronario agudo 16 .…”

Section: Introductionunclassified

Índice neutrófilo-linfocitario en la predicción de trombosis temprana del stent

Blanco¹,

Quert²,

Medina³

2020

RACI

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Introducción. La inflamación es el principal mecanismo propuesto en la génesis fisiopatológica de la trombosis del stent. Una expresión del estado inflamatorio es el índice neutrófilo linfocitario. Objetivo. Evaluar el valor pronóstico del índice neutrófilo linfocitario en la predicción de trombosis temprana del stent. Método. Investigación prospectiva en el Hospital Hermanos Ameijeiras, La Habana, Cuba, entre diciembre de 2018 y junio 2019. Resultados. Se estudiaron 196 pacientes; las variables niveles elevados de neutrófilo (p=0,009) e índice neutrófilo linfocitario (p=0,007) después del proceder se relacionan significativamente con la presencia de trombosis del stent y la curva ROC encontró una sensibilidad de 70% y una especificidad de 62% para un nivel del índice mayor de 6 (0,712; IC95%: 0,610-0,988; p=0,012). Conclusión. El aumento del índice neutrófilo-linfocitario a las 6 horas del intervencionismo coronario percutáneo, tiene alta sensibilidad y alta especificidad en la predicción de trombosis temprana del stent.

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Relation of Neutrophil to Lymphocyte Ratio With Periprocedural Myocardial Damage in Patients Undergoing Elective Percutaneous Coronary Intervention

Cited by 12 publications

References 18 publications

Correlation of neutrophil-to-lymphocyte ratio with the prognosis of non-ST-segment elevation in patients with acute coronary syndrome undergoing selective percutaneous coronary intervention

Correlation of neutrophil-to-lymphocyte ratio with the prognosis of non-ST-segment elevation in patients with acute coronary syndrome undergoing selective percutaneous coronary intervention

Impact of Tourniquet Use on Systemic Inflammatory Parameters, Functional Physical Recovery, and Cardiovascular Outcomes of Patients Undergoing Knee Arthroplasty: A Case-Control Study

Índice neutrófilo-linfocitario en la predicción de trombosis temprana del stent

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