Relation of neurocardiovascular instability to cognitive, emotional and functional domains

Bendini, Chiara; Angelini, A; Salsi, Francesca; Finelli, Me; Martini, Emilio; Neviani, Francesca; Mussi, Chiara; Neri, Mirco

doi:10.1016/j.archger.2007.01.010

Cited by 21 publications

(17 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A longitudinal study [8] found no differences on the MMSE score between the OH group and the non OH group. The same results were disclosed in a small sample size transversal study [9]. Lastly, in a recent study among 2321 community older adults, OH was not associated with cognitive decline assessed by MMSE in the overall population but a significant relationship was observed among hypotensive people where OH increased the risk of cognitive impairment [10].…”

Section: Discussionsupporting

confidence: 53%

“…This implies that any abrupt change in BP will result in a rapid and significant change in cerebral blood flow (CBF) [6]. Few studies, to date, have examined the relationship between OH and cognitive decline and their results have been contradictory [8][9][10]. The aim of this study was to examine the association between OH and cognitive function in elderly people.…”

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Relationship between orthostatic hypotension and cognitive impairment in the elderly

Mehrabian

Duron

Labourée

et al. 2010

Journal of the Neurological Sciences

117

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 53%

Section: Introductionmentioning

confidence: 97%

Relationship between orthostatic hypotension and cognitive impairment in the elderly

Mehrabian

Duron

Labourée

et al. 2010

Journal of the Neurological Sciences

117

View full text Add to dashboard Cite

“…However, debate about relations between brain structure and function and orthostatic hypotension remains controversial. Many studies have not shown a significant relation between hypotension and cognition . Conversely, a few studies have shown significant relations between orthostatic hypotension and cognitive or subclinical brain injury.…”

Section: Discussionmentioning

confidence: 99%

Inter‐Relations of Orthostatic Blood Pressure Change, Aortic Stiffness, and Brain Structure and Function in Young Adults

Cooper

Himali

Torjesen

et al. 2017

JAHA

View full text Add to dashboard Cite

BackgroundRelations of orthostatic change in blood pressure with brain structure and function have not been studied thoroughly, particularly in younger, healthier individuals. Elucidation of factors that contribute to early changes in brain integrity may lead to development of interventions that delay or prevent cognitive impairment.Methods and ResultsIn a sample of the Framingham Heart Study Third Generation (N=2119; 53% women; mean age±SD, 47±8 years), we assessed orthostatic change in mean arterial pressure (MAP), aortic stiffness (carotid‐femoral pulse wave velocity), neuropsychological function, and markers of subclinical brain injury on magnetic resonance imaging. Multivariable regression analyses were used to assess relations between orthostatic change in MAP and brain structural and neuropsychological outcomes. Greater orthostatic increase in MAP on standing was related to better Trails B‐A performance among participants aged <49 years (β±SE, 0.062±0.029; P=0.031) and among participants with carotid‐femoral pulse wave velocity <6.9 m/s (β±SE, 0.063±0.026; P=0.016). This relation was not significant among participants who were older or had stiffer aortas. Conversely, greater orthostatic increase in MAP was related to larger total brain volume among older participants (β±SE, 0.065±0.029; P=0.023) and among participants with carotid‐femoral pulse wave velocity ≥6.9 m/s (β±SE, 0.078±0.031; P=0.011).ConclusionsBlunted orthostatic increase in MAP was associated with smaller brain volume among participants who were older or had stiffer aortas and with poorer executive function among persons who were younger or who had more‐elastic aortas. Our findings suggest that the brain is sensitive to orthostatic change in MAP, with results dependent on age and aortic stiffness.

show abstract

“…Alternatively, orthostatic hypotension may result in neurodegeneration mediated by cerebral hypoperfusion. Management of OH includes modification of culprit medications, particularly antihypertensive and antipsychotic medications . Other intervention strategies include physical counter maneuvers, adding salt and increasing fluid intake, and medications such as midodrine and fludrocortisone.…”

Section: Discussionmentioning

confidence: 99%

Orthostatic Blood Pressure Behavior in People with Mild Cognitive Impairment Predicts Conversion to Dementia

Hayakawa

McGarrigle

Coen

et al. 2015

J American Geriatrics Society

View full text Add to dashboard Cite

show abstract

Relation of neurocardiovascular instability to cognitive, emotional and functional domains

Cited by 21 publications

References 28 publications

Relationship between orthostatic hypotension and cognitive impairment in the elderly

Relationship between orthostatic hypotension and cognitive impairment in the elderly

Inter‐Relations of Orthostatic Blood Pressure Change, Aortic Stiffness, and Brain Structure and Function in Young Adults

Orthostatic Blood Pressure Behavior in People with Mild Cognitive Impairment Predicts Conversion to Dementia

Contact Info

Product

Resources

About