“…15 Going to the bottom characteristics of FCS, it is evident that the components of the FCS, such as macronutrients (unsaturated to saturated fat ratio, fiber to carbohydrate ratio, protein, and specific lipids), vitamins, minerals (including selenium) and phytochemicals, as well as additives and degree of food procession, are related to inflammation, and consequently to CVD 10,26,27 or related cardiometabolic diseases. 28 Antioxidant vitamins C and E, carotenoids, micronutrients, and polyphenols, which are also constructive elements of the FCS, have been shown to modulate oxidative stress 29,30 and inhibit platelet activating factor, 31 which is a potent mediator of inflammation. 32 Methyl donors, such as choline and B-vitamins reduce homocysteine concentration 33 and possibly have an anti-inflammatory activity, 34 which may further explain the association of FCS with CVD risk.…”