Relation of Massive Bowel Resection to Gastric Secretion

Frederick, Paul L.; Sizer, Jack S.; Osborne, Michael

doi:10.1056/nejm196503112721004

Cited by 131 publications

(26 citation statements)

References 11 publications

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“…The high incidence of peptic disease was not surprising because increased gastric secretions [17] and hypergastrinemia [18] are well-known features of short bowel syndrome. The findings of friability, loss of vascular pattern, and patchy erythema, and prominent eosinophilia are consistent with prior reports of allergic disease [15].…”

Section: Discussionmentioning

confidence: 99%

High diagnostic yield of gastrointestinal endoscopy in children with intestinal failure

Ching

Modi

Jaksic

et al. 2008

Journal of Pediatric Surgery

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Purpose-Children with intestinal failure (IF) often have gastrointestinal (GI) symptoms, including bleeding, increased stool output, and feeding intolerance. The use of endoscopic assessment of these symptoms has not been previously reported. This report evaluates the diagnostic yield of GI endoscopy in the setting of IF.Methods-After institutional review board approval, we reviewed the medical records (including endoscopy, pathology and microbiology data) of patients with IF who underwent GI endoscopies between September 1999 and March 2007.Results-Twenty-seven patients underwent 61 GI endoscopies: 34 esophagogastroduodenoscopies, 17 colonoscopies, 7 flexible sigmoidoscopies, and 3 ileoscopies. Indications for endoscopy, which were not mutually exclusive, included chronic diarrhea (39%, n = 24), GI bleeding (36%, n = 22), suspected bacterial overgrowth (36%, n = 22), and suspected peptic disease (15%, n = 9). Based on gross endoscopic appearance, histopathology, or microbiology, 43 (70%) procedures yielded abnormalities. These included infectious (20%, n = 12), anatomical (18%, n = 11), peptic (15%, n = 9), allergic (15%, n = 9), and other (2%, n = 1) findings. Eleven (73%) of 15 duodenal cultures grew a spectrum of 17 bacterial species. Overall, 24 (89%) of 27 patients had gross endoscopic, histopathologic, or microbiologic abnormalities. Conclusions-In

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Section: Discussionmentioning

confidence: 99%

High diagnostic yield of gastrointestinal endoscopy in children with intestinal failure

Ching

Modi

Jaksic

et al. 2008

Journal of Pediatric Surgery

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“…Gastric acid secretion is increased in dogs with denervated gastric pouches. In man some cases of long-term survival in patients with a short bowel has been attributed to their previous gastric surgery [43][44][45] . High circulating gastrin levels are observed [40,46,47] and may be due to less small bowel being available to catabolizegastrin [48,49] .…”

Section: Gastrointestinal Secretionsmentioning

confidence: 99%

Management of patients with a short bowel

Nightingale

1999

Nutrition

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“…Initial observations in humans came from the surgical literature where patients with previous vagotomies and gastrectomies for ulcers did better than others after extensive bowel resection (108,109). Subsequently, gastric hypersecret1on has not been shown in humans universally, and many authors doubt its existence or feel that it is only a temporary problem (86,104).…”

Section: Treatmentmentioning

confidence: 99%

Short Bowel Syndrome: Intestinal Adaptation and Medical Therapy

Buie¹,

Og²,

Fedorak³

1990

Canadian Journal of Gastroenterology

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Short bowel syndrome is a clinical entity, a consequence of significant loss of intestinal surface area, and manifests a variable picture of diarrhea, steatorrhea, malabsorprion and weight loss. Previously high mortality rates have been reduced by the early use of parenteral nutrition and have subsequently resulted in increased survival and prevalence of the condition. Ultimate patient survival is dependent on the intrinsic adaptive ability of residual intestine and this, in tum, is dependent upon length, type, functional state and the presence or absence of an ileocecal valve. The mechanisms of intestinal adaptation are not entirely understood; however, they can be grouped into three broad categories: luminal nutrition, hormonal factors, and pancreaticobiliary secretion. Medical treatment of short bowel syndrome remains supportive and centres around the control of th ree pathophysiological defects: decreased intestinal transit time, gastric hypersecretion, and reduced functional mucosa! surface area.

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Relation of Massive Bowel Resection to Gastric Secretion

Cited by 131 publications

References 11 publications

High diagnostic yield of gastrointestinal endoscopy in children with intestinal failure

High diagnostic yield of gastrointestinal endoscopy in children with intestinal failure

Management of patients with a short bowel

Short Bowel Syndrome: Intestinal Adaptation and Medical Therapy

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