Relation of left ventricular sphericity to 10-year survival after acute myocardial infarction

Wong, Selwyn; French, John K.; Lydon, Anna‐Maria; Manda, Samuel; Gao, Wanzhen; Ashton, Noel G.; White, Harvey D.

doi:10.1016/j.amjcard.2004.07.110

Cited by 70 publications

(51 citation statements)

References 18 publications

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“…Left ventriculography was performed 2 weeks after AMI, and the LV end-diastolic volume (LVEDV) and ejection fraction (LVEF) were measured using the right anterior oblique view of left ventriculograms by the area-length method. LV sphericity index was calculated from ratio between right anterior oblique short and long axes [27]. All angiographic studies were interpreted by two experienced angiographers without the knowledge of patients’ background.…”

Section: Methodsmentioning

confidence: 99%

Impact of Serum C-Reactive Protein Elevation on the Left Ventricular Spherical Change and the Development of Mitral Regurgitation after Anterior Acute Myocardial Infarction

Kohno

Anzai²,

Naito³

et al. 2007

Cardiology

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Background/Aims: Mitral regurgitation (MR) is frequently observed in patients with acute myocardial infarction (AMI), and is known to convey an adverse prognosis. We sought to clarify the relationship between MR and left ventricular (LV) remodeling, in association with serum C-reactive protein (CRP) elevation. Methods/Results: A total of 181 patients with first anterior ST-elevation AMI were examined. MR was detected in 68 patients by color Doppler echocardiography 2 weeks after AMI, and the patients with MR were associated with higher incidence of readmission for heart failure. Serum CRP was serially measured, and the peak serum CRP level was markedly increased in patients with MR compared with those without MR. Multiple logistic regression analysis showed that peak CRP tertile was an independent determinant of MR after AMI (p < 0.0001). In the substudy, the increases in LV end-diastolic volume and sphericity index were higher in patients with MR than in those without MR. Conclusions: MR during the early phase of anterior AMI was associated with LV spherical change and late-phase heart failure, in association with increased serum CRP level. These findings suggest an important role of the inflammatory response in the development of ischemic MR and LV remodeling.

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Section: Methodsmentioning

confidence: 99%

Impact of Serum C-Reactive Protein Elevation on the Left Ventricular Spherical Change and the Development of Mitral Regurgitation after Anterior Acute Myocardial Infarction

Kohno

Anzai²,

Naito³

et al. 2007

Cardiology

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“…At the macroscopic level, these alterations in myocardial structure and function result in changes in LV shape and volume, findings detected clinically with imaging tests as structural LV abnormalities (dilation or increased mass), altered LV geometry, and LV systolic and diastolic dysfunction. LV remodeling has been identified as a fundamental precursor of clinical HF and of HF progression, with more extensive remodeling changes associated with worse prognosis [6,[12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Screening for ventricular remodeling

Lee¹,

Wang²,

Vasan

2006

Curr Heart Fail Rep

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Current guidelines emphasize the importance of preventing heart failure (HF) by targeting people with preclinical forms of the disease. Accordingly, there is considerable interest in identifying left ventricular (LV) remodeling, the fundamental substrate for HF, in asymptomatic individuals in the community. Increased LV mass and asymptomatic LV systolic and LV diastolic dysfunction are the remodeling phenotypes that could be potentially considered for population-wide screening. Plasma levels of natriuretic peptides (NP) have been extensively investigated for such screening purposes. However, a majority of investigations suggest that their performance characteristics are suboptimal for identifying LV remodeling phenotypes unless high-risk individuals (eg, older men with hypertension) are targeted. In general, the prevalence of LV systolic dysfunction in women is too low to justify screening. In recent reports, sequential screening strategies combining urine and plasma NP or plasma NP and hand-held portable echocardiography have been advocated as potential approaches to identify asymptomatic LV systolic dysfunction in a cost-effective manner. Additional studies are warranted to confirm these findings.

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“…This effect may be of therapeutic relevance and constitutes a different approach than simply inhibiting the hypertrophic response. It should be noted that left ventricular geometry is an independent predictor for mortality after acute myocardial infarction [57] and interventions aiming to preserve cardiac geometry are sought. So far, cardiac support devices, which ensure passive epicardial constraint seem to confer some benefit [58].…”

Section: Th Improves Cardiac Function By Optimizing Cardiac Geometrymentioning

confidence: 99%

Rebuilding the post-infarcted myocardium by activating ‘physiologic’ hypertrophic signaling pathways: the thyroid hormone paradigm

2008

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Viable myocardium undergoes several changes in the course of cardiac remodeling following myocardial infarction aiming to adapt the heart to the hemodynamic compromise. This response is characterized by reactivation of the fetal transcriptional program and results in cardiac dysfunction. Changes in thyroid hormone (TH)-TH receptors (TRs) axis occur in the course of post-infarction cardiac remodeling and seem to contribute to cardiac fetal phenotype. TH can "rebuild" the post-infarcted heart by preventing the fetal-like pattern of contractile proteins expression, normalizing wall tension, and optimizing cardiac chamber geometry. This effect seems to be attributed to TH pleiotropic cellular actions; TH promotes tissue growth and differentiation and favorably remodels cardiac cell while increases cellular survival upon stress. TH may constitute a new therapeutic option for mending the ischemic myocardium.

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Relation of left ventricular sphericity to 10-year survival after acute myocardial infarction

Cited by 70 publications

References 18 publications

Impact of Serum C-Reactive Protein Elevation on the Left Ventricular Spherical Change and the Development of Mitral Regurgitation after Anterior Acute Myocardial Infarction

Impact of Serum C-Reactive Protein Elevation on the Left Ventricular Spherical Change and the Development of Mitral Regurgitation after Anterior Acute Myocardial Infarction

Screening for ventricular remodeling

Rebuilding the post-infarcted myocardium by activating ‘physiologic’ hypertrophic signaling pathways: the thyroid hormone paradigm

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