Relation of iron stores to oxidative stress in type 2 diabetes

Kundu, Debtosh; Roy, Anita; Mandal, Tanuka; Bandyopadhyay, Ujjwal; Ghosh, Enakshi; Ray, Debes

doi:10.4103/1119-3077.106776

Cited by 23 publications

(14 citation statements)

References 2 publications

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“…In blood stream small fraction of serum Fe is transported by a glycoprotein, called transferrin into the cells [18]. In the body tissues, ferritin stores free Fe, which is increased in newly diagnosed diabetic subjects [19,20]. Jiang et al manifested higher level of ferritin in diabetics as compared to the non-diabetic subjects.…”

Section: Introductionmentioning

confidence: 99%

Metals in the pathogenesis of type 2 diabetes

Khan

Awan

2014

J Diabetes Metab Disord

113

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Minerals are one of the components of food, though they are not synthesized in the body but they are essential for optimal health. Several essential metals are required for the proper functioning of many enzymes, transcriptional factors and proteins important in various biochemical pathways. For example Zn, Mg and Mn are cofactors of hundreds of enzymes, and Zn is involved in the synthesis and secretion of insulin from the pancreatic beta-cells. Similarly, Cr enhances the insulin receptor activity on target tissues, especially in muscle cells. Insulin is the key hormone required to maintain the blood glucose level in normal range. In case of insulin deficiency or resistance, blood glucose concentration exceeds the upper limit of the normal range of 126 mg/dl. Persistent increase of blood serum glucose level leads to overt chronic hyperglycemia, which is a major clinical symptom of diabetes mellitus. Poor glycemic control and diabetes alters the levels of essential trace elements such as Zn, Mg, Mn, Cr, Fe etc. by increasing urinary excretion and their concomitant decrease in the blood. Hence, the main purpose of this review is to discuss the important roles of essential trace elements in normal homeostasis and physiological functioning. Moreover, perturbation of essential trace elements is also discussed in perspective of type 2 diabetes pathobiology.

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Section: Introductionmentioning

confidence: 99%

Metals in the pathogenesis of type 2 diabetes

Khan

Awan

2014

J Diabetes Metab Disord

113

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“…The part of the Iron in the bloodstream is transferred in to the cell by a glycoprotein molecule called transferrin [13,14]. That according to many studies serum Iron level changes is observed in patients with diabetes [15,16].…”

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confidence: 99%

Evaluation of Serum Iron, Zinc and Their Relationships with Glycemic Control Status in Iranian Elderly Women with Type 1 Diabetes Mellitus

Mohammadian¹,

Milani²,

Hassas³

et al. 2015

JPP

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It seems that defects on micro-minerals levels have an etiologic role involved in type 1 diabetes mellitus pathogenicity. The aim of our study were to evaluate the serum levels of zinc and iron and investigate their possible relationship between these biochemical parameters with demographic conditions and glycemic control in patients with type 1 diabetes mellitus disorder. In this case-control based study , 68 female with type 1 diabetes mellitus with a mean age of 52.2 ± 2 as case group and 122 healthy women as a control group with a mean age of 49/4 ± 3/2 were investigated .for biochemical analysis ,10 mL fasting venous blood sample were obtained from each subjects. FBS (fasting blood glucose), fructosamine (glycemic control parameter) were determined (spectrophotometry method, (pars azmoon, Iran), nitroblue tetrazoline method respectively).serum zinc level with colorimetric method (Biorex-UK) and serum iron with photometric method (pars azmoon, Iran) were determined. Statistical analysis using SPSS software performed. Significant levels considered as P < 0.05. According to this study there is statistically significant difference between serum levels of iron and zinc in patients with type 1 diabetes compared to controls .indeed serum level of iron and zinc had lower level in patient group toward controls. In patients group, there are a positive correlation between age and decreased level of serum zinc (P < 0.05). Also there was a significant negative correlation between the glycemic control status and serum zinc. Other studied parameters concluded BMI (body mass index), Weight and height have not significant difference between groups. The decrease in serum iron and zinc level in women with type 1 diabetes may be related to low dietary intake or increased excretion of micro minerals or the presence of confounding factors that require more extensive intervention studies to confirm it.

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“…However, they showed that a positive correlation exists between iron deficiency anemia and increased A1C levels, and therfore, A1C levels increase in anemia. Kunduet al 16 showed that serum ferritin levels were highest in diabetics with A1C >8% (p<0.001) but they also did not find direct correlation between ferritin and A1C. In a small study by Padwal MK et al 8 high serum ferritin levels were found to be correlated to metabolic syndrome and insulin resistance.…”

Section: Discussionmentioning

confidence: 96%

Correlation of Serum Ferritin in Type 2 Diabetes with Glyscosylated Haemoglobin and its relation after 3 months of follow up

Mathur¹

2018

jmscr

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Relation of iron stores to oxidative stress in type 2 diabetes

Cited by 23 publications

References 2 publications

Metals in the pathogenesis of type 2 diabetes

Metals in the pathogenesis of type 2 diabetes

Evaluation of Serum Iron, Zinc and Their Relationships with Glycemic Control Status in Iranian Elderly Women with Type 1 Diabetes Mellitus

Correlation of Serum Ferritin in Type 2 Diabetes with Glyscosylated Haemoglobin and its relation after 3 months of follow up

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