Relation of hs-CRP and BNP levels with the atrial spontaneous echo contrast and thrombi in permanent atrial fibrillation patients with different etiologies

Şahı̇n, Tayfun; Acar, Eser; Kılıç, Teoman; Kozdağ, Güliz; Ağaçdiken, Ayşen; Ural, Dilek

doi:10.12659/msm.882461

Cited by 14 publications

(10 citation statements)

References 42 publications

(63 reference statements)

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“…Previous studies have contributed to our understanding of the role of inflammation in AF by showing that Hs-CRP [ 6 – 8 , 33 ] and NLR are associated with AF [ 9 – 11 ]. According to the review by Bhat et al, the association of NLR with AF has not been evaluated in detail.…”

Section: Discussionmentioning

confidence: 99%

Novel fibro-inflammation markers in assessing left atrial remodeling in non-valvular atrial fibrillation

et al. 2014

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BackgroundStructural remodeling is associated with the fibroinflammatory process in the atrial extracellular matrix. In the present study we aimed to investigate whether serum levels of new circulating remodeling markers differ in patients with atrial fibrillation (AF) compared to patients with sinus rhythm.Material/MethodsThe study population included 52 patients diagnosed with non-valvular AF and 33 age-matched patients with sinus rhythm. Serum levels of Galectin-3, matrix metalloproteinase-9 (MMP-9), lipocalin-2 (Lcn2/NGAL), N-terminal propeptide of type III procollagen (PIIINP), Hs-Crp, and neutrophil-to-lymphocyte ratio (NLR) were measured. The left atrial volume (LAV) was calculated by echocardiographic method and LAV index was calculated.ResultsGalectin-3, MMP-9, and PIIINP levels were significantly higher in AF patients except NGAL levels (1166 pg/ml (1126–1204) and 1204 pg/ml (1166–1362) p=0.001, 104 (81–179) pg/ml and 404 (162–564) pg/ml p<0.0001, and 1101 (500–1960) pg/ml and 6710 (2370–9950) pg/ml p<0.0001, respectively). The NLR and Hs-CRP levels were also higher in AF (2.1±1.0 and 2.7±1.1 p=0.02 and 4.2±1.9 mg/L and 6.0±4.7 mg/L p=0.04, respectively). In correlation analyses, NLR showed a strongly significant correlation with LAVi, but Hs-CRP did not (p=0.007 r=0.247, Pearson test and p=0.808 r=0.025, Pearson test, respectively). Moreover, Galectin-3, MMP-9, and PIIINP had a strong positive correlation with LAVi (p=0.021 r=640, Spearman test and p=0.004 r=0.319 Pearson test, and p=0.004 r=0.325 Pearson test, respectively).ConclusionsNovel fibrosis and inflammation markers in AF are correlated with atrial remodeling. Several unexplained mechanisms of atrial remodeling remain, but the present study has taken the first step in elucidating the mechanisms involving fibrosis and inflammation markers.

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Section: Discussionmentioning

confidence: 99%

Novel fibro-inflammation markers in assessing left atrial remodeling in non-valvular atrial fibrillation

et al. 2014

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“…The relationship between SEC and left atrial as well as LAA diameter and functions has been firmly established (8). In addition, the relationship between several biomarkers and SEC has been examined, but there is no a complete consensus in this regard (9). Despite these various studies, the exact mechanisms of SEC have not been fully elucidated.In the current study, the left atrial and aortic blood viscosity and peripheral smears, morphology and function of the LAA and left atrium, and pulmonary vein flow patterns were examined in detail, in an effort to shed a light on the etiology of SEC.…”

Section: Discussionmentioning

confidence: 99%

Illumination of Spontaneous Echo Contrast With Hemorheology and Echocardiography in Mitral Stenosis

Bilgel

Güllü

Hamad

et al. 2021

Preprint

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Backround: Spontaneous echo contrast (SEC) is an echocardiographic finding particularly found in left atrium of patients with mitral stenosis (MS) and known as a risk factor for stroke. However, its pathophysiology is not fully understood. Methods: Forty-eight patients with MS scheduled for percutaneous mitral valvuloplasty were included in the study. Blood samples were taken from the aorta and left atrium (LA) during the procedure. Whole blood viscosity (WBV), plasma viscosity (PV) and peripheral blood smears were obtained and analysed separately from these sites. All participants underwent transthoracic and transesophageal echocardiography prior to the procedure Results: Severe SEC (grade 3-4) was found in 23 patients, remaining 25 patients had mild to moderate SEC (grade 0-1-2). Patients with severe SEC had increased LA diameter, area and PV. However, ejection fraction, left atrial appendage (LAA) filling and emptying velocities, LAA lateral wall late systolic velocity, LAA fractional area change and pulmonary vein (PVe) systolic velocity were found to be significantly reduced in patients with severe SEC compared to mild to moderate SEC. On multiple linear regression analysis, atrial fibrillation, left atrium PV and diameter were strongly correlated with SEC grade (Respectively p=0,011, p=0,013, p=0,030). Conclusion: We have shown that AF, systolic dysfunction of LAA and left ventricule, reduced PVe flow velocity, increased LA dimensions and left atrial PV were related with the severity of SEC in patients with mitral stenosis. We demonstrated the relationship between the increase left atrial PV and SEC in addition to impaired hemodynamic determinants in patients with mitral stenosis.

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“…The relationship between SEC and left atrial as well as LAA diameter and functions has been firmly established (8). Also, the link between several biomarkers and SEC has also been examined (9). Despite these various studies, the exact mechanisms of SEC have not been fully elucidated.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Echo Contrast in Mitral Stenosis: Why and How?

Bilgel

Güllü

Hamad

et al. 2020

Preprint

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Background: Spontaneous echo contrast (SEC) is an echocardiographic finding particularly found in left atrium of patients with mitral stenosis and known as a risk factor for stroke. However, its pathophysiology is not fully understood. Material and Method: Forty-eight patients with mitral stenosis scheluded for percutaneous mitral valvuloplasty were included in the study. The severity of SEC was graded from 0 to 4 according to its density. Blood samples were taken from the aorta and left atrium during the procedure. Whole blood viscosity, plasma viscosity and peripheral blood smears were obtained and analysed separately from these sites. Results: Severe SEC (grade 3-4) was found in 23 patients (48%), remaining 25 patients (52%) had mild to moderate SEC (grade 0-1-2). The patients with atrial fibrillation (AF) and hypertension (HT) had more significantly severe SEC compared to other patients. A history of stroke, rouleaux formation at the peripheral smears, mitral valve area, transmitral diastolic gradient, left atrial mean wall velocities and total atrial conduction time were not different between two groups. Compared to patients with mild to moderate SEC, patients with severe SEC had increased age, body mass index (BMI), left atrial diameter, left atrial area and left atrial plasma viscosity (PV). However, ejection fraction, left atrial appendage (LAA) filling and emptying velocities, LAA lateral wall late systolic velocity, LAA fractional area change and pulmonary vein (PVe) systolic velocity were found to be significantly reduced in patients with severe SEC compared to mild to moderate SEC. On multiple linear regression analysis, AF, left atrium PV and left atrial diameter were the strongly correlated with SEC grade. Conclusion: In conclusion, we have shown that AF, HT, systolic dysfunction of LAA, increased left atrial dimensions, reduced ejection fraction, decreased PVe flow velocity and increased left atrial PV were related with the development of SEC in patients with mitral stenosis.

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Relation of hs-CRP and BNP levels with the atrial spontaneous echo contrast and thrombi in permanent atrial fibrillation patients with different etiologies

Cited by 14 publications

References 42 publications

Novel fibro-inflammation markers in assessing left atrial remodeling in non-valvular atrial fibrillation

Novel fibro-inflammation markers in assessing left atrial remodeling in non-valvular atrial fibrillation

Illumination of Spontaneous Echo Contrast With Hemorheology and Echocardiography in Mitral Stenosis

Spontaneous Echo Contrast in Mitral Stenosis: Why and How?

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