Relation of frequency and severity of mitral regurgitation to survival among patients with left ventricular systolic dysfunction and heart failure

Trichon, Benjamin H.; Felker, G. Michael; Shaw, Linda K.; Cabell, Christopher H.; O’Connor, Christopher M.

doi:10.1016/s0002-9149(02)03301-5

Cited by 627 publications

(374 citation statements)

References 12 publications

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“…The association between mitral insufficiency and death or hospitalization for heart failure is consistent across different categories of the mitral insufficiency variable and appears to increase with increasing severity of mitral insufficiency. Several recent studies have found similar results, with mitral insufficiency being associated with poorer long-term outcomes, including more symptoms (8,12) and death (8,(9)(10)(11). The incidence of mitral insufficiency in these studies was higher (43% to 70%) than in the current study of SOLVD trial patients (15%).…”

Section: Discussionsupporting

confidence: 80%

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Mitral insufficiency and morbidity and mortality in left ventricular dysfunction

Baskett

Exner

Hirsch

et al. 2007

Canadian Journal of Cardiology

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Section: Discussionsupporting

confidence: 80%

“…Other recent studies have demonstrated adverse outcomes associated with mitral insufficiency in patients with left ventricular dysfunction (9)(10)(11)(12).…”

mentioning

confidence: 98%

Mitral insufficiency and morbidity and mortality in left ventricular dysfunction

Baskett

Exner

Hirsch

et al. 2007

Canadian Journal of Cardiology

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“…This is termed mitral regurgitation (MR), and severe cases of MR can lead to left ventricular dysfunction and congestive heart failure. 41 Poor leaflet coaptation is the endpoint through which MR occurs, and one specific syndrome is termed mitral valve prolapse (MVP), which affects about 2% of the anterior posterior A B 3 population 13 and is defined as superior displacement greater than 2 mm of one or both leaflets into the atrium during systole (Fig. 2).…”

Section: Mitral Regurgitation and Mitral Valve Prolapsementioning

confidence: 99%

Development of a Simultaneous Cryo-Anchoring and Radiofrequency Ablation Catheter for Percutaneous Treatment of Mitral Valve Prolapse

Boronyak

Merryman

2012

Ann Biomed Eng

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“…This result is consistent with previous studies in which left ventricular size and EF have failed to consistently predict mortality or arrhythmic events. 7,11 Although mitral regurgitation and left atrial volume have been previously associated with overall mortality, 12 we are unaware of any studies that have focused on a specific relationship with ventricular arrhythmias.…”

Section: Discussionmentioning

confidence: 99%

A Restrictive Inflow Pattern Does Not Predict Implantable Cardioverter‐Defibrillator Therapy in Primary Prevention

Dorosz

Aaronson

Good

et al. 2009

Clinical Cardiology

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Background Current guidelines for the use of implantable cardioverter‐defibrillators (ICDs) are broad and significantly increase the cost of caring for patients with heart failure. In an effort to identify the specific subset of patients who benefit from this therapy, the predictive value of numerous echocardiographic parameters have been studied. Severe diastolic dysfunction has been shown to predict adverse events in a group of patients who received an ICD for secondary prevention, but has not been tested in those who receive ICDs for primary prevention. Hypothesis We tested the hypothesis that a restrictive mitral inflow pattern on echocardiography will predict the risk of appropriate therapy in this patient population. Methods This retrospective study identified 145 consecutive patients who met primary prevention criteria for ICD implantation and had an echo performed no more than 1 year prior to receiving the ICD. A restrictive pattern was defined as a mitral inflow E/A > 2 or a deceleration time < 150 ms. Results A restrictive pattern was present in 69 patients (40.7% of the group). Appropriate ICD therapy occurred in 8 (11.5%) subjects with a restrictive pattern and 14 (18.4%) with a nonrestrictive pattern over 680 days of average follow‐up (P = not significant). Cox regression analysis showed the presence of a restrictive pattern was not helpful in predicting time to first ICD therapy. Conclusions In a population of patients who received ICDs for primary prevention, echocardiographic findings of severe diastolic dysfunction were not helpful in targeting the use of ICDs to those at highest risk. Copyright © 2009 Wiley Periodicals, Inc.

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Relation of frequency and severity of mitral regurgitation to survival among patients with left ventricular systolic dysfunction and heart failure

Cited by 627 publications

References 12 publications

Mitral insufficiency and morbidity and mortality in left ventricular dysfunction

Mitral insufficiency and morbidity and mortality in left ventricular dysfunction

Development of a Simultaneous Cryo-Anchoring and Radiofrequency Ablation Catheter for Percutaneous Treatment of Mitral Valve Prolapse

A Restrictive Inflow Pattern Does Not Predict Implantable Cardioverter‐Defibrillator Therapy in Primary Prevention

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