Relation of Fasting Triglyceride-Rich Lipoprotein Cholesterol to Coronary Artery Calcium Score (from the ELSA-Brasil Study)

Bittencourt, Márcio Sommer; Santos, Raul D.; Staniak, Henrique Lane; Sharovsky, Rodolfo; Kondapally, Rao; Vallejo‐Vaz, Antonio J.; Ray, Kausik K.; Benseñor, Isabela M.; Lotufo, Paulo A

doi:10.1016/j.amjcard.2017.01.033

Cited by 29 publications

(31 citation statements)

References 24 publications

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“…Despite the relatively low cardiovascular risk of our study population, the higher AIP was still associated with the higher CACS. related with CAC, even more than LDL-C [20,21]. If the range of AIP in our study was wider with more extreme values, it may have resulted in a significant relationship.…”

Section: Discussionmentioning

confidence: 66%

Association between Atherogenic Index of Plasma and Coronary Artery Calcification Progression in Korean Adults

Nam¹,

Kim

Nam³

et al. 2020

Preprint

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Background Dyslipidemia is a well-known risk factor for cardiovascular disease (CVD). Recently, atherogenic index of plasma (AIP) has been proposed as a novel predictive marker for CVD, and there are few cross sectional studies that demonstrated a relationship between AIP and coronary artery disease. We investigated the association between AIP and the progression of coronary artery calcification (CAC) in Korean adults without CVD. Methods A total of 1,124 participants who had undergone CAC measurement at least twice by multi-detector CT in a health care center were enrolled. Anthropometric profiles and multiple cardiovascular risk factors were assessed. The AIP was defined as the base 10 logarithm of the ratio of the concentration of TG to HDL-C. The CAC progression was defined as either incident CAC in a CAC-free population at baseline or an increase of ≥ 2.5 units between the square roots of the baseline and follow-up coronary artery calcium scores (CACS) among subjects with detectable CAC at baseline Results CAC progression was observed in 290 subjects (25.8%) during the mean 4.2 years of follow-up. All subjects were stratified into three groups according to AIP. There were significant differences in cardiovascular parameters among the groups at baseline. The follow-up CAC and the incidence of CAC progression increased gradually with the rising AIP tertiles. In the logistic regression analysis, the odds ratio for CAC progression was 2.27 when comparing the highest to the lowest tertile of the AIP (95% CI: 1.61-3.19; P for trend <0.01). However, this association was attenuated after adjustment for multiple risk factors (P for trend = 0.67). Conclusions There is a significant correlation between AIP and CAC and its progression in subjects without CVD, but AIP is not an independent predictor of CAC progression.

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Section: Discussionmentioning

confidence: 66%

Association between Atherogenic Index of Plasma and Coronary Artery Calcification Progression in Korean Adults

Nam¹,

Kim

Nam³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Previous studies showed that high TG and low HDL-C were closely associated Fig. 2 The change in coronary artery calcification according to AIP tertile Δ √transformed CACS and annualized Δ √transformed CACS values increased across the tertiles of AIP at baseline (T1: lowest AIP tertile, T2: second AIP tertile, T3: highest AIP tertile) with CAC, even more than LDL-C [21,22]. If the range of AIP in this study was wider with more extreme values, it may have resulted in a significant relationship.…”

Section: Discussionmentioning

confidence: 94%

Association between atherogenic index of plasma and coronary artery calcification progression in Korean adults

et al. 2020

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Background: Dyslipidemia is a well-known risk factor for cardiovascular disease (CVD). Recently, atherogenic index of plasma (AIP) has been proposed as a novel predictive marker for CVD, and few cross sectional studies have demonstrated a relationship between AIP and coronary artery disease. The present study investigated the association between AIP and the progression of coronary artery calcification (CAC) in Korean adults without CVD. Methods: A total of 1124 participants who had undergone CAC measurement at least twice by multi-detector computed tomography (CT) at a health checkup center were enrolled. Their anthropometric measurements and various cardiovascular risk factors were assessed. AIP was defined as the base 10 logarithm of the ratio of the concentration of triglyceride (TG) to high-density lipoprotein-cholesterol (HDL-C). CAC progression was defined as either incident CAC in a CAC-free population at baseline, or an increase of ≥2.5 units between the square roots of the baseline and follow-up coronary artery calcium scores (CACS) in subjects with detectable CAC at baseline. Results: CAC progression was observed in 290 subjects (25.8%) during the mean follow-up of 4.2 years. All subjects were stratified into three groups according to AIP. There were significant differences in cardiovascular parameters among groups at baseline. The follow-up CAC and the incidence of CAC progression increased gradually with rising AIP tertiles. In logistic regression analysis, the odds ratio for CAC progression was 2.27 when comparing the highest to the lowest tertile of AIP (95% CI: 1.61-3.19; P for trend < 0.01). However, this association was attenuated after adjustment for multiple risk factors (P for trend = 0.67). Conclusions: There is a significant correlation between AIP and the progression of CAC in subjects without CVD. Although AIP was not an independent predictor of CAC progression, AIP should be considered when estimating the current as well as future CVD risk, along with other traditional risk factors.

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“…Physicians use various lipid-lowering drugs to control LDL-C and non-HDL-C levels to prevent cardiovascular disease (22). Recent studies have also found that a high levels of TRLRs is an important risk factor for cardiovascular disease (23,24). All of these findings suggest that PPT could increase the risk of cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Elevated Levels of Apolipoprotein CIII Increase the Risk of Postprandial Hypertriglyceridemia

et al. 2021

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BackgroundTo investigate possible mechanisms of postprandial hypertriglyceridemia (PPT), we analyzed serum lipid and apolipoprotein (Apo) AI, B, CII and CIII levels before and after a high-fat meal.MethodsThe study has been registered with the China Clinical Trial Registry (registration number:ChiCTR1800019514; URL: http://www.chictr.org.cn/index.aspx). We recruited 143 volunteers with normal fasting triglyceride (TG) levels. All subjects consumed a high-fat test meal. Venous blood samples were obtained during fasting and at 2, 4, and 6 hours after the high-fat meal. PPT was defined as TG ≥2.5 mmol/L any time after the meal. Subjects were divided into two groups according to the high-fat meal test results: postprandial normal triglyceride (PNT) and PPT. We compared the fasting and postprandial lipid and ApoAI, ApoB, ApoCII and ApoCIII levels between the two groups.ResultsSignificant differences were found between the groups in fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), TG, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), TG-rich lipoprotein remnants (TRLRs), ApoB, ApoCIII, ApoAI/ApoB and ApoCII/ApoCIII. The insulin, HOMA-IR, TG, TC, LDL-C, non-HDL-C, TRLRs, ApoB, ApoCIII and ApoCII/ApoCIII values were higher in the PPT group, while the ApoAI/ApoB ratio was higher in the PNT group. The postprandial TG level peaked in the PNT group 2 hours after the meal but was significantly higher in the PPT group and peaked at 4 hours. TRLRs gradually increased within 6 hours after the high-fat meal in both groups. The area under the curve (AUC) of TG and TRLRs and the AUC increment were higher in the PPT group (P < 0.001). ApoCIII peaked in the PNT group 2 hours after the meal and gradually decreased. ApoCIII gradually increased in the PPT group within 6 hours after the meal, exhibiting a greater AUC increment (P < 0.001). Fasting ApoCIII was positively correlated with age, systolic and diastolic blood pressure, body mass index (BMI), waist circumference, TC, TG, LDL-C, non-HDL-C, TRLRs, and ApoB (P<0.05). ApoCIII was an independent risk factor of PPT after adjustment for BMI, waist circumference, TC, LDL-C, and ApoB (P < 0.001, OR=1.188).ConclusionsElevated ApoCIII levels may cause PPT.

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Relation of Fasting Triglyceride-Rich Lipoprotein Cholesterol to Coronary Artery Calcium Score (from the ELSA-Brasil Study)

Cited by 29 publications

References 24 publications

Association between Atherogenic Index of Plasma and Coronary Artery Calcification Progression in Korean Adults

Association between Atherogenic Index of Plasma and Coronary Artery Calcification Progression in Korean Adults

Association between atherogenic index of plasma and coronary artery calcification progression in Korean adults

Elevated Levels of Apolipoprotein CIII Increase the Risk of Postprandial Hypertriglyceridemia

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