Relation of family history of prostate cancer to perceived vulnerability and screening behavior

Jacobsen, Paul B.; LaMonde, Laurie A.; Honour, Melissa; Kash, Kathryn M.; Hudson, Perry B.; Pow‐Sang, Julio M.

doi:10.1002/pon.760

Cited by 71 publications

(68 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast to others (16), perceived risk does not mediate the relationship between family history and screening. It is possible that physicians were more likely to refer men with a family history of prostate cancer for PSA testing, whereas men with higher perceived risk initiated screening themselves.…”

Section: Discussioncontrasting

confidence: 61%

“…However, in another study, men with a family history of prostate cancer (half of the sample of 166 men) reported greater perceived vulnerability and were more likely to report their intention to be screened and to have been screened in the past. Perceived vulnerability mediated the relationship between family history and intention to be screened (16). In summary, recent studies indicate that heightened perception of cancer risk and moderate worries are strong predictors of screening (17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Family History, Perceived Risk, and Prostate Cancer Screening among African American Men

Bloom

Stewart

Oakley-Girvans

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Background: Many African American men have two major risk factors for prostate cancer. By ethnicity alone, they have twice the risk of Euro-American men of developing prostate cancer. Having a family history (brother or father with prostate cancer) also doubles their risk. The major hypotheses tested in this study are that men with a family history perceive their risk to be higher, are more worried about getting prostate cancer, and are more likely to have used cancer screening tests than men without such a history. Methods: A sample of 208 African American men, ages 40 to 74 years, were recruited through relatives or friends whose prostate cancer diagnosis was reported to the California Cancer Registry during the years 1997 to 2001 and from churches and African American social groups. Following a screening interview to determine eligibility, 88 men with self-reported, first-degree family history of prostate cancer

show abstract

Section: Discussioncontrasting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Family History, Perceived Risk, and Prostate Cancer Screening among African American Men

Bloom

Stewart

Oakley-Girvans

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

show abstract

“…Studies have reported that men with a family history are more likely to have a PSA test (McDavid et al, 2000;Jacobsen et al, 2004), others found no association between family history and screening uptake (Taylor et al, 1999;Miller et al, 2001).…”

mentioning

confidence: 99%

Feasibility of familial PSA screening: psychosocial issues and screening adherence

et al. 2006

View full text Add to dashboard Cite

This study examined factors that predict psychological morbidity and screening adherence in first-degree relatives (FDRs) taking part in a familial PSA screening study. Prostate cancer patients (index cases -ICs) who gave consent for their FDRs to be contacted for a familial PSA screening study to contact their FDRs were also asked permission to invite these FDRs into a linked psychosocial study. Participants were assessed on measures of psychological morbidity (including the General Health Questionnaire; Cancer Worry Scale; Health Anxiety Questionnaire; Impact of Events Scale); and perceived benefits and barriers, knowledge; perceived risk/ susceptibility; family history; and socio-demographics. Of 255 ICs, 155 (61%) consented to their FDRs being contacted. Of 207 FDRs approached, 128 (62%) consented and completed questionnaires. Multivariate logistic regression revealed that health anxiety, perceived risk and subjective stress predicted higher cancer worry (P ¼ 0.05). Measures of psychological morbidity did not predict screening adherence. Only past screening behaviour reliably predicted adherence to familial screening (P ¼ 0.05). First-degree relatives entering the linked familial PSA screening programme do not, in general, have high levels of psychological morbidity. However, a small number of men exhibited psychological distress.

show abstract

“…14,15 As the contribution of BRCA2 and other genes to hereditary prostate cancer is clarified, 16,17 and the effectiveness of screening in men at increased risk becomes better understood, this situation may change. Meanwhile, it is likely that men with a family history of prostate cancer have unmet needs as they live with increased worry, 18 feelings of vulnerability about developing this condition, 19,20 and concern for their sons. 21 As a first step to developing genetic services for hereditary prostate cancer, this study aimed to identify the information and support needs of men with a family history of prostate cancer and to explore their preferences for how these needs could be met.…”

mentioning

confidence: 99%

Genetic services for men: The preferences of men with a family history of prostate cancer

Gaff

Cowan

Meiser

et al. 2006

Genetics in Medicine

View full text Add to dashboard Cite

Purpose: Men have a lower uptake of genetic services than women; however, the specific needs and preferences of men at risk of genetic conditions other than hereditary breast ovarian cancer are not known. We ascertain the information preferences of men with a family history of prostate cancer. Methods: Unaffected men and their partners were administered a written questionnaire. Results: Responses were received from 280 men (response rate: 59.2%) and 174 partners (response rate: 74%). Most men (59.6%) reported having insufficient information about their risk and wanted further information about personal risk (93.2%) and risk management (93.6%). Strikingly, 56.3% preferred to receive information related only to positive outcomes. Urologists were the preferred source of information, but there was considerable interest in a multidisciplinary service approach significantly associated with the number of affected relatives (odds ratio ϭ 1.94, P Ͻ .002). Partners' level of concern was not associated with interest in multidisciplinary services, satisfaction with information, or support received. Conclusions: Delivering services to men at risk will require a multifaceted approach by primary care providers and specialists. Challenges include meeting men's expectations in the face of uncertain medical knowledge, engaging those at high risk in multidisciplinary services, and delivering tailored information to those at lower risk. Men have a lower uptake of genetic services 1,2 and genetic testing 3 than women and may have different responses to coping with and disclosing genetic information. 3,4 Despite these differences, men's preferences for genetic service delivery have not been sought or identified. In cancer genetics particularly, the delivery of genetic services has been largely influenced by the experiences of women with, or at risk of developing, hereditary breast-ovarian cancer. 5-7 One retrospective study examined the needs of men with BRCA1 and BRCA2 mutations and found them generally satisfied with genetic counseling, but this did not ascertain preferences. It cannot be assumed that men at risk of other hereditary cancer predispositions have the same needs as men with mutations predisposing predominantly to breast cancer. Understanding men's preferences for the delivery of cancer genetic information becomes important when considering services for men with a family history of prostate cancer. These men have a risk of developing prostate cancer that increases with the number of affected relatives and a decreasing age of diagnosis. 8 -11 An autosomal dominant form (hereditary prostate cancer) has been defined, 8 and 2% to 3% of all prostate cancer cases meet these criteria, with up to one third of cases diagnosed before 60 years possibly caused by dominantly inherited mutations in susceptibility genes. 12 Nonetheless, the molecular basis of susceptibility remains unclear. 13 Currently, it is uncommon for men with a family history suggestive of hereditary prostate cancer to be seen in cancer genetics clinics. In Aus...

show abstract

Relation of family history of prostate cancer to perceived vulnerability and screening behavior

Cited by 71 publications

References 16 publications

Family History, Perceived Risk, and Prostate Cancer Screening among African American Men

Family History, Perceived Risk, and Prostate Cancer Screening among African American Men

Feasibility of familial PSA screening: psychosocial issues and screening adherence

Genetic services for men: The preferences of men with a family history of prostate cancer

Contact Info

Product

Resources

About