Relation of distortion product otoacoustic emission and tinnitus in normal hearing patients: A pilot study

Modh, Datt; Katarkar, Ashish; Alam, Noorain; Jain, Anil K.; Shah, Pankaj

doi:10.4103/1463-1741.132078

Cited by 18 publications

(3 citation statements)

References 10 publications

(11 reference statements)

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“…These results suggest that OHC loss may be a primary initiator in a series of events leading to tinnitus. Evidence based on clinical cases corroborates this hypothesis because patients suffering from tinnitus exhibit significantly lower amplitudes of otoacoustic emissions (generating from OHCs) than do persons without tinnitus [ 39 ]. Thus, it is assumed that reduced OHC activity is related to the generation of tinnitus.…”

Section: Partial Lesions Of the Cochleamentioning

confidence: 99%

Neural Hyperactivity of the Central Auditory System in Response to Peripheral Damage

Zhao

Song

et al. 2016

Neural Plasticity

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It is increasingly appreciated that cochlear pathology is accompanied by adaptive responses in the central auditory system. The cause of cochlear pathology varies widely, and it seems that few commonalities can be drawn. In fact, despite intricate internal neuroplasticity and diverse external symptoms, several classical injury models provide a feasible path to locate responses to different peripheral cochlear lesions. In these cases, hair cell damage may lead to considerable hyperactivity in the central auditory pathways, mediated by a reduction in inhibition, which may underlie some clinical symptoms associated with hearing loss, such as tinnitus. Homeostatic plasticity, the most discussed and acknowledged mechanism in recent years, is most likely responsible for excited central activity following cochlear damage.

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Section: Partial Lesions Of the Cochleamentioning

confidence: 99%

Neural Hyperactivity of the Central Auditory System in Response to Peripheral Damage

Zhao

Song

et al. 2016

Neural Plasticity

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“…A foundation of modification in spontaneous activity within the auditory system could be an injury or abnormal task at any level, from the cochlea to the highest levels of the auditory system [ 3 ]. It had been also founded that there is an association between tinnitus and reduced outer hair cells activity which indicate the outer hair cells of cochlea are involved in the generation of tinnitus [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Patients with tinnitus and normal hearing constitute an uncommon group and there is rare literature on tinnitus cases with normal hearing [ 4 ]. On the other hand there are many literature discussed tinnitus in patients with SNHL, like Sermin Kibar et al whom stated that “it was observed that simultaneously administration of vitamin B12 during noise had no protective effect on permanent threshold shift ” [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

The use of distortion product otoacoustic emissions (DPOAE) records to estimate effect of vitamin B complex on changing severity of tinnitus

Hameed

Eleue

Mosawi

2018

Annals of Medicine and Surgery

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IntroductionPatients that are complaining from tinnitus but have normal hearing comprise an uncommon group and there is rare literature about them. Deficiency in B-complex vitamins has been shown to result in tinnitus and supplementation may improve the symptom which means manipulation of cochlear status. Distortion Product Otoacoustic emissions (DPOAEs) used frequently to assess cochlear status.ObjectivesThe uses of DPOAE changing amplitude as a parameter to estimate effect of vitamin B complex on changing the severity of tinnitus in patients with tinnitus only in comparison to patients have tinnitus with Sensory Neural Hearing Loss (SNHL) and a control group.MethodsProspective observational cohort study was performed in AL-Karama Teaching Hospital as a secondary medical care center, from 01/01/2012 to 31/12/2016. A three groups had been evaluated clinically and by OAE device (ECHOLAB) to study the DPOAE changing amplitude before and after one month of supplementation of B-complex vitamins to 25 patients in study group (1) have (tinnitus only) and also to 25 patients in study group (2) have (Tinnitus + SNHL) but leaving control group who were a 25 medical staff (No Tinnitus and nor SNHL) without treatment.ResultsIt has been found that among Study group 1 (patients had Tinnitus only), Study group 2 (patients had Tinnitus + SNHL) and the control group: 16 patients (44%), P-value = 0.000 HS; 28 patients (78%) P-value = 0.000 HS; and 0% respectively, they had low Amplitude of DPOAE recorded by OAE device (ECHOLAB). After one month from treatment with Neurobine ampules for study group 1& 2 but not control group (whom receive no treatment), those who got clinical improvement + increase Amplitude of DPOAE (i.e. subjective + objective changes) after treatment were 10 patients (28%) P-value = 0.000 HS in study group1, and two patients (5%) P-value 0.321 NS in study group 2, and there was no changes (zero) among control group.ConclusionsThe uses of DPOAE changing amplitude could be used as a parameter to estimate effect of vitamin B complex on changing the severity of Tinnitus in patients with tinnitus only or those have Tinnitus with SNHL. The supplementation of vitamin B complex could improve the tinnitus severity especially in patients with tinnitus without SNHL.

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Correlation between clinical characteristics and tinnitus severity in tinnitus patients of different sexes: an analytic retrospective study

Yuan

Chen

et al. 2022

Eur Arch Otorhinolaryngol

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Relation of distortion product otoacoustic emission and tinnitus in normal hearing patients: A pilot study

Cited by 18 publications

References 10 publications

Neural Hyperactivity of the Central Auditory System in Response to Peripheral Damage

Neural Hyperactivity of the Central Auditory System in Response to Peripheral Damage

The use of distortion product otoacoustic emissions (DPOAE) records to estimate effect of vitamin B complex on changing severity of tinnitus

Correlation between clinical characteristics and tinnitus severity in tinnitus patients of different sexes: an analytic retrospective study

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