Relation of dispersion of QRS and QT in patients with advanced congestive heart failure to cardiac and sudden death mortality

Anastasiou-Nana, Maria; Nanas, John N.; Karagounis, Labros A.; Tsagalou, Eleftheria P.; Alexopoulos, Georgios; Toumanidis, S.; Gerali, Sophia; Stamatelopoulos, Stamatios; Moulopoulos, Spyridon D.

doi:10.1016/s0002-9149(00)00730-x

Cited by 67 publications

(46 citation statements)

References 13 publications

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“…Anastasiou-Nana et al followed 104 class II-IV NYHA heart failure patients with systolic dysfunction (left ventricular ejection fraction < 35%) for 20 ± 12 months, with cardiac death as the end-point (12 (measured by magnetic resonance imaging) (13).…”

Section: Qrd Dispersion In Heart Failurementioning

confidence: 99%

Is there a utility for QRS dispersion in clinical practice?

Donoiu¹,

Târtea²,

Chávez-González³

2017

J Mind Med Sci.

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Keywords: 12-lead electrocardiogram, cardiomyopathy and heart failure, myocardial infarction. AbstractPrognostic markers derived from standard ECG have always been seductive.Increased dispersion of durations of the P wave, of the QRS complex, or of the QT interval has been associated with the risk of atrial fibrillation, ventricular arrhythmias, sudden cardiac death, as well as with a general negative prognosis in various settings.However, these markers have intrinsic and methodological issues that question their utility. This paper presents data supporting the utility of QRS dispersion in clinical practice. Our investigation shows that QRS dispersion is a simple electrocardiographic marker with potential value in the assessment of patients in a variety of clinical settings: ischemic heart disease, heart failure, and cardiomyopathies.More studies are needed to validate QRS clinical utility for predicting the risk for ventricular arrhythmias and sudden cardiac death, and for the evaluation of the response to cardiac resynchronization therapy.Acne conglobata is a rare, severe form of acne vulgaris characterized by the presence of comedones, papules, pustules, nodules and sometimes hematic or meliceric crusts, located on the face, trunk, neck, arms and buttocks.Ionuț Donoiu et al. 133

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Section: Qrd Dispersion In Heart Failurementioning

confidence: 99%

Is there a utility for QRS dispersion in clinical practice?

Donoiu¹,

Târtea²,

Chávez-González³

2017

J Mind Med Sci.

View full text Add to dashboard Cite

show abstract

“…However, in the later decompensated stages of the disease, a wide QRS complex (>120 ms) has been reported to be a predictor of mortality in CHF patients. 4,5 A wide QRS complex may be caused by slow impulse conduction, which is an important parameter for reentrant arrhythmias. In turn, conduction slowing may be due to several factors, which include reduced electrical coupling in the ventricular myocardium due to reduced expression of the main gap junction protein Connexin43 (Cx43), reduced excitability mediated by the sodium channel and enhanced collagen deposition (fibrosis).…”

Section: N T E R U N I V E R S I T Y C a R D I O L O G Y I N S T I mentioning

confidence: 99%

Longitudinal arrhythmogenic remodelling in a mouse model of longstanding pressure overload

Boulaksil¹,

Noorman²,

Engelen³

et al. 2010

NHJL

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“…In addition, the increased inhomogeneity of ventricular repolarization, induced by LVH, can be indirectly detected by QT dispersion, a relatively simple measurement of 12-lead electrocardiogram (ECG) variability, and this index has been recently shown to be related to poor prognosis in large population studies (Okin 2000, Salles 2005, Elming 1998, Bruyne 1998, Sheehana 2004. Interestingly, heterogeneous ventricular repolarization was initially recognized in standard ECGs as early as 1934; however only recently QTc interval dispersion was identified as a marker of arrhythmia risk and sudden cardiac death in patients after myocardial infarction or with heart failure (Barr 1994, Glancy 1995, Anastasiou-Nana 2000. Furthermore, other studies subsequently demonstrated the presence of increased QT-dispersion in patients with systemic arterial hypertension, associated with ventricular arrhythmias and LVH (Dimopoulos 2008, Clarkson 1995, Mayet 1996.…”

Section: Qt-interval and Qt-dispersionmentioning

confidence: 99%

“…The direct linking mechanism between QT-dispersion, ventricular arrhythmias, LVH and adverse outcome has not been fully clarified yet. Increased QTc dispersion has been associated with increased regional heterogeneity of ventricular repolarization and it has been considered as a possible noninvasive surrogate marker of susceptibility to malignant ventricular arrhythmias and cardiovascular mortality in large population studies and, in cardiac patients (Okin 2000, Elming 1998, Bruyne 1998, Sheehana 2004, Barr 1994, Glancy 1995, Anastasiou 2000. The degree of myocardial interstitial fibrosis induced by either systemic arterial hypertension and/or by ageing, as well as the inhomogeneous myocyte hypertrophy caused mainly by arterial hypertension, might play an important role in increasing action potential duration and amplitude in different myocardial regions (Dimopoulos 2008(Dimopoulos ,2009.…”

Section: Qt-interval and Qt-dispersionmentioning

confidence: 99%