Relation of DDE and PBB serum levels in farm residents, consumers, and Michigan Chemical Corporation employees.

Wolff, Mary S.; Aubrey, Bertrand; Camper, Frances; Haymes, Neil

doi:10.1289/ehp.7823177

Cited by 26 publications

(7 citation statements)

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“…Mean serum PBB values, depicted in Table 1 and ranked graphically (Figs. 1 and 2) ranged lower for family groups resident on nonquarantined farms April 1978 than for quarantined farm families. Family clustering of serum PBB is suggested by the standard deviation from the mean family value, which tended to fall within a limited range such that the highest values did not overlap lower values.…”

Section: Resultsmentioning

confidence: 90%

“…PBB contamination of dairy farms in Michigan occurred as an episode of relatively short duration, primarily since 1973. The major route of exposure to PBB was probably by ingestion of contaminated food and indeed, significantly different serum PBB values have been found among dairy farm residents of quarantined and nonquarantined farms (1). Presumably, animal food sources from quarantined farms would tend to represent a more concentrated exposure source.…”

mentioning

confidence: 99%

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Family clustering of PBB and DDE values among Michigan dairy farmers.

Wolff¹,

Haymes²,

Anderson³

et al. 1978

Environ Health Perspect

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Family clustering of varying levels of serum PBB and DDE was evaluated for 62 Michigan families by using the mean and standard deviation for family units, ranked percentile comparison of family members, and correlation by linear regression of family members. The results indicate that levels of serum PBBs cluster within family units and for children within families. Serum DDE clustering within families occurs only for children. These findings are consistent with recent, interim PBB exposure, perhaps from a common dietary source for families. Serum DDE represents a lifetime, low-level exposure to DDT-DDE which has been both less prolonged and less intense for children. Thus similar levels, or clustered serum DDE, was observed for children within families.

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Section: Resultsmentioning

confidence: 90%

mentioning

confidence: 99%

Family clustering of PBB and DDE values among Michigan dairy farmers.

Wolff¹,

Haymes²,

Anderson³

et al. 1978

Environ Health Perspect

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“…Males tended to have a higher prevalence of cigarette smoking, and when they smoked, did so more heavily. Wolff et al (11) found serum PBB concentrations to be higher among males tested. Further, as demonstrated here, serum PBB affects CEA titer and is additive to the effect of smoking.…”

Section: Discussionmentioning

confidence: 93%

Carcinoembryonic antigen (CEA) plasma levels in Michigan and Wisconsin dairy farmers.

Anderson¹,

Rosenman²,

Snyder³

1978

Environ Health Perspect

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Carcinogenic embryonic antigen (CEA) titers were determined for 611 Michigan farmers exposed to PBB and a control nonexposed population of 138 Wisconsin farmers.The overall prevalence of elevated CEA titers was slightly higher in the Michigan study group, but the difference was not statistically significant. Smoking and/or significant past or present conditions (inflammatory bowel disease, ulcers, polyps, liver disease, chronic lung disease, or malignancies) were found to result in higher prevalence of elevated CEA titers, in both the Michigan study group and the Wisconsin control group, thus confirming previous reports.In addition, serum PBB concentrations appeared to be positively correlated with CEA titers. The possibility that the effect of PBB may be additive to that of other factors which are known to result in an increased prevalence of elevated CEA titers is discussed.

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“…Serum analytical methodology is described elsewhere (20). Since individual pure isomers were not available for calibration, analysis of component peaks was accomplished by calculating relative peak areas, setting the major 2,4,5,2',4',5'-hexabromobiphenyl peak at 100%.…”

Section: Methodsmentioning

confidence: 99%

PBB Homologs in Sera of Michigan Dairy Farmers and Michigan Chemical Workers

Wolff¹,

Aubrey²

1978

Environmental Health Perspectives

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JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org. . The National Institute of Environmental Health Sciences (NIEHS) and Brogan & Partners are collaborating with JSTOR to digitize, preserve and extend access to Environmental Health Perspectives. 1029 persons in Michigan for the potential health effects of exposure to PBB. Included in this group were 55 persons from Michigan Chemical Corporation and 237 farming families. Blood serum was analyzed for PBB.FireMaster FF-1 contains several bromobiphenyl components, the major constituent being approximately 60% 2,4,4,2'4'4'-hexabromobiphenyl. Other PBB homologs identifiable as peaks by gas chromatography-mass spectrometry include two pentabromobiphenyl peaks, three additional hexabromobiphenyl peaks, and two heptabromobiphenyl peaks. The relative concentrations, with respect to the major hexabromobiphenyl peak, of these minor constituents (1-20%) of PBB were different for persons from Michigan Chemical Corporation and for farmers.Penta-, hexa-, and hepta-bromobiphenyl components in serum samples analyzed from farming families from Michigan and from Michigan Chemical Corporation employees were compared with relative concentrations of these homologs in FireMaster mixture and in tissue and blood samples from rats fed FireMaster FF-1. Varying concentrations of these PBB components are attributed to different routes of exposure and the relative ease of metabolism and excretion of one pentabromobiphenyl component.

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Relation of DDE and PBB serum levels in farm residents, consumers, and Michigan Chemical Corporation employees.

Cited by 26 publications

References 1 publication

Family clustering of PBB and DDE values among Michigan dairy farmers.

Family clustering of PBB and DDE values among Michigan dairy farmers.

Carcinoembryonic antigen (CEA) plasma levels in Michigan and Wisconsin dairy farmers.

PBB Homologs in Sera of Michigan Dairy Farmers and Michigan Chemical Workers

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