Relation of coffee consumption and serum liver enzymes in Japanese men and women with reference to effect modification of alcohol use and body mass index

Ikeda, Makoto; Maki, Takako; Yin, Guang; Kawate, Hisaya; Adachi, Masahiro; Ohnaka, Keizo; Takayanagi, Ryoichi; Kono, Suminori

doi:10.3109/00365511003650165

Cited by 32 publications

(30 citation statements)

References 30 publications

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“…Coffee consumption was inversely related with serum level of liver enzymes in the study including Japanese men and women (Ikeda et al, 2010). In the current study, alcohol consumption showed a nonsignificant association with ALT similar to the study performed in Japan (Nakamura et al, 1998;Nakamura et al, 1980).…”

Section: Resultssupporting

confidence: 72%

Serum Alanine Aminotransferase (ALT) Activity among Diabetic Patients

Upadhayay

2016

Int J Appl Sci Biotechnol

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Serum Alanine aminotransferase (ALT) activity is the most common screening test as a part of routine assessment of liver damage. Due to its low activity in extra hepatic tissues an increase in serum ALT is more specific for liver disease. The liver pathology among diabetics is similar to that of alcoholic liver disease, including fatty liver, steatohepatitis, fibrosis, and cirrhosis. Thus, elevated serum ALT activity which is a common sign of liver disease is also observed more frequently in diabetics. This study has been designed with the aim to determine the association of serum ALT activity with diabetes mellitus. The study included 208 subjects attending Nepal police hospital during the time frame 6 th October 2009 to 4 th January 2010.The ALT activity in serum was determined by kit method, fasting and post prandial sugar was tested by GOD-POD method.Among the total diabetic subjects 43.26% were found to have elevated serum ALT activity (>40IU/L). Diabetic status was found to be significantly associated with ALT activity (p=0.04). In addition to diabetic status body mass index (BMI) was also significantly associated with ALT activity (p=0.02) and higher BMI increases the likelihood of elevated ALT. The association of ALT activity was found to be inverse and significant with age of the patient(r=-0.217, p=0.005). Physical activity was also found to be inversely associated with ALT activity(r=-0.149, p=0.03).

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Section: Resultssupporting

confidence: 72%

Serum Alanine Aminotransferase (ALT) Activity among Diabetic Patients

Upadhayay

2016

Int J Appl Sci Biotechnol

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“…11,18-20 Some fairly large populationbased studies suggested that coffee drinking inhibited AST and ALT activities in Japan, Italy, and the United States. 8,11,21 AST and ALT are used as markers of liver inflammation. Abnormally elevated serum aminotransferase levels result from heterogeneous causes such as viral infection, drug toxicity, obesity, and excessive alcohol.…”

Section: Discussionmentioning

confidence: 99%

“…Also, the alcohol-related rise in aminotransferases was attenuated with coffee drinking in a Japanese study. 11 Until now, there have been limited numbers of Asian studies on coffee and liver function tests. Liver functions tests are indicators of hepatocellular health.…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Coffee Drinking and Liver Function Tests in Korean Men

Rae

SuhSang-Yeon

SeoAh-Ram

et al. 2014

Journal of Caffeine Research

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Background: Coffee is known to have a protective effect on liver enzymes. There are a limited number of Asian studies on this subject. We investigated the relationship between coffee and liver function tests in Korean men on a large scale. Methods: Study participants were consecutive men who had a regular health checkup in a university hospital in Korea. Information on coffee intake, alcohol drinking, and smoking was collected through selfadministered questionnaires. Results: A total of 3,844 men were enrolled in this study. Coffee drinking was positively associated with smoking and alcohol drinking. Coffee drinking was inversely associated with aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) concentrations (r = À1.33, p = 0.008 and r = À6.35, p = 0.007, respectively). Also, increasing levels of coffee consumption was inversely associated with AST and GGT in a multivariate model ( p < 0.001 and p < 0.001, respectively). The relationship between coffee drinking status and alanine aminotransferase (ALT) did not reach statistical significance. However, heavy coffee consumption ( ‡ 3 cups/day) was significantly inversely related to ALT compared with mild coffee consumption ( < 1 cup/day) and non-coffee drinkers in multivariate analyses ( p = 0.032). All multivariate models were adjusted for age, body mass index, regular exercise, smoking amount, and alcohol drinking status. Conclusions: Coffee drinking was inversely associated with AST and GGT in apparently healthy Korean men. The relationship showed a dose-response pattern. It was suggested that ALT was lower in heavy coffee consumers ( ‡ 3 cups/day) compared with mild coffee consumers ( < 1 cup/day) and non-coffee drinkers.

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“…One hypothesis involves the observation that coffee consumption is associated with better lifestyle choices, confounding the positive effects that had been associated with coffee consumption. One previously discussed cohort study argues against this hypothesis, demonstrating subjects that were prone to increased coffee consumption actually had higher median consumption of cigarettes, lower education levels, and higher median intake of alcohol than those with decreased coffee consumption[16]. …”

Section: Discussionmentioning

confidence: 99%

“…A 2010 study in Japan evaluated levels of AST, ALT, and GGT amongst various subgroups of men and women with high BMI, low BMI, and high and low alcohol consumption. Transaminases were noted to be lower amongst men and women with higher coffee consumption, the relationship appearing to be stronger in those with higher alcohol consumption and lower BMI[16]. …”

Section: Coffee and An Association With Decreased Liver Enzymesmentioning

confidence: 99%

Coffee: The magical bean for liver diseases

Heath

Brahmbhatt

Tahan

et al. 2017

WJH

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Coffee has long been recognized as having hepatoprotective properties, however, the extent of any beneficial effect is still being elucidated. Coffee appears to reduce risk of hepatocellular carcinoma, reduce advancement of fibrotic disease in a variety of chronic liver diseases, and perhaps reduce ability of hepatitis C virus to replicate. This review aims to catalog the evidence for coffee as universally beneficial across a spectrum of chronic liver diseases, as well as spotlight opportunities for future investigation into coffee and liver disease.

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Relation of coffee consumption and serum liver enzymes in Japanese men and women with reference to effect modification of alcohol use and body mass index

Abstract: Coffee drinking probably confers protection against alcohol-related increase in liver enzymes.

Cited by 32 publications

References 30 publications

Serum Alanine Aminotransferase (ALT) Activity among Diabetic Patients

Serum Alanine Aminotransferase (ALT) Activity among Diabetic Patients

The Relationship between Coffee Drinking and Liver Function Tests in Korean Men

Coffee: The magical bean for liver diseases

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