Relation of Chronic Obstructive Pulmonary Disease to Cardiovascular Disease in the General Population

Song, Seungkeun; Yang, Pil Sung; Kim, Tae Hoon; Uhm, Jae Sun; Pak, Hui Nam; Lee, Moon Hyoung; Joung, Boyoung

doi:10.1016/j.amjcard.2017.07.032

Cited by 21 publications

(13 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Older age, reduced gas exchange and airflow obstruction, right atrial overload and ventricular overload and hypertrophy and selected comorbidities are the main negative prognostic indicators as they could account for early death in these patients [ 1 – 3 ].…”

Section: Introductionmentioning

confidence: 99%

Relative lymphocyte count as an indicator of 3-year mortality in elderly people with severe COPD

et al. 2018

View full text Add to dashboard Cite

BackgroundPrognostic stratification of elderly patients with chronic obstructive pulmonary disease (COPD) is difficult due to the wide inter-individual variability in the course of the disease. No marker can exactly stratify the evolution and natural history of COPD patients. Studies have shown that leukocyte count is associated with increased risk of mortality in COPD patients. The aim of this study was to evaluate the possible role of relative lymphocyte count as a risk marker for mortality in elderly patients with COPD.Methods and resultsThis is a3-year prospective study. A total of 218patients, mean age 75.2±7 years, with moderate to severe COPD and free from conditions affecting lymphocyte count were enrolled. The population was divided into two groups according to the relative lymphocyte count, with a cut-off of 20%. Eighty-five patients (39%) had a relative lymphocyte count ≤20%. Three-year mortality rates from any cause in patients with relative lymphocyte count ≤ or > 20% were 68 and 51%, respectively (p = 0.0012). Survival curve analysis showed higher mortality in patients with relative lymphocyte count ≤20% (p = 0.0005). After adjustment for age and sex, the hazard ratio for mortality risk according to lymphocyte count was 1.79 (95% confidence interval [CI]: 1.26–2.57, p = 0.0013), even in the analysis limited to the 171 patients without congestive heart failure (1.63; 95% CI: 1.03–2.58, p = 0.038).ConclusionsLow relative lymphocyte count was associated with higher mortality in elderly patients with severe COPD.Electronic supplementary materialThe online version of this article (10.1186/s12890-018-0685-6) contains supplementary material, which is available to authorized users.

show abstract

Section: Introductionmentioning

confidence: 99%

Relative lymphocyte count as an indicator of 3-year mortality in elderly people with severe COPD

et al. 2018

View full text Add to dashboard Cite

show abstract

“…LBBB in the absence of a clinically detectable heart disease is associated with new-onset heart failure and death from cardiovascular diseases. Further study is warranted to determine if additional diagnostic testing or earlier treatment in patients with asymptomatic LBBB can decrease cardiovascular morbidity or mortality [19]. Our study had shown that LBBB is predictor of mortality in COPD patients.…”

Section: Resultsmentioning

confidence: 77%

Electrocardiographic predictors of five-years mortality in chronic obstructive pulmonary disease patients

et al. 2021

View full text Add to dashboard Cite

Introduction/Objective. Cardiovascular disease is one of the most common comorbidities among subjects with chronic obstructive pulmonary disease (COPD). The aim of this study is to evaluate ECG parameters and mortality predictors in COPD patients. Methods. A total of 835 consecutive patients were included. Patients were classified to suffer from COPD if in three consecutive postbronhodilatator measurements FEV1/FVC was <70%. Following ECG changes were observed: axis, p wave, low ORS complex, transitional zone, left bundle branch block (LBBB), right bundle branch block (RBBB), incomplete right bundle branch block, S1S2S3 configuration, negative T in V1-V3. Patients were followed up for mortality in a five years period. Results. Both survivors and non-survivors were similar age, gender and COPD status. FVC and FEV1 as well as GOLD stadium are significantly higher in surviving group (p<0.016, p<0.001, p<0.001 respectively). Normal axis was in significantly higher percentage in non-survived patients (p=0.020). Right RBBB and incomplete RBB are more frequent finding in patients who died as (p?0.001, p?0.05, respectively). LBBB, S1S2S3 configuration is in significantly higher percent in non survivors (p<0.016, p<0.001, respectively). In multivariable logistic model, patients with LBBB have two times higher chance of mortality compared to patients without LBBB. Contrary, patients with RBBB have 1.6 times lower chance to have death outcome. Conclusion. Main ECG predictors of COPD patients? five-year mortality are LBBB and RBBB, but according to statistical model, electrocardiogram should be further explored and possibly obligatory involved in a routine clinical practice as an easy and low-cost screening method.

show abstract

“…First, in such studies using administrative databases, coding inaccuracies can lead to errors. Hence, we applied the definition that we had already validated in previous studies to minimize the problem [21,[24][25][26][27][28]. Second, since the health examination of individuals was conducted in different hospitals and clinics, a uniformity of BP measurement could not be achieved.…”

Section: Limitationsmentioning

confidence: 99%

What Is the Ideal Blood Pressure Threshold for the Prevention of Atrial Fibrillation in Elderly General Population?

Park

Yang

et al. 2020

JCM

Self Cite

View full text Add to dashboard Cite

Intensive blood pressure (BP) lowering in patients with hypertension at increased risk of cardiovascular disease has been associated with a lowered risk of incident atrial fibrillation (AF). It is uncertain whether maintaining the optimal BP levels can prevent AF in the general elderly population. We included 115,866 participants without AF in the Korea National Health Insurance Service-Senior (≥60 years) cohort from 2002 to 2013. We compared the influence of BP on the occurrence of new-onset AF between octogenarians (≥80 years) and non-octogenarians (<80 years) subjects. With up to 6.7 ± 1.7 years of follow-up, 4393 incident AF cases occurred. After multivariable adjustment for potentially confounding clinical covariates, the risk of AF in non-octogenarians was significantly higher in subjects with BP levels of <120/<80 and ≥140/90 mm Hg, with hazard ratios of 1.15 (95% confidence interval (CI), 1.03–1.28; p < 0.001) and 1.14 (95% CI, 1.04–1.26; p < 0.001), compared to the optimal BP levels (120–129/<80 mm Hg). In octogenarians, the optimal BP range was 130–139/80–89 mm Hg, higher than in non-octogenarians. A U-shaped relationship for the development of incident AF was evident in non-octogenarians, and BP levels of 120–129/<80 mm Hg were associated the lowest risk of incident AF. Compared to non-octogenarians, the lowest risk of AF was associated with higher BP levels of 130–139/80–89 mm Hg amongst octogenarians.

show abstract

Relation of Chronic Obstructive Pulmonary Disease to Cardiovascular Disease in the General Population

Cited by 21 publications

References 19 publications

Relative lymphocyte count as an indicator of 3-year mortality in elderly people with severe COPD

Relative lymphocyte count as an indicator of 3-year mortality in elderly people with severe COPD

Electrocardiographic predictors of five-years mortality in chronic obstructive pulmonary disease patients

What Is the Ideal Blood Pressure Threshold for the Prevention of Atrial Fibrillation in Elderly General Population?

Contact Info

Product

Resources

About