Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population: systematic review and meta-analysis

Kuo, Hsu-Ko; Yen, Chung‐Jen; Chang, Chia‐Hsuin; Kuo, Chen Ko; Chen, Jen Hau; Sorond, Farzaneh A.

doi:10.1016/s1474-4422(05)70099-5

Cited by 335 publications

(282 citation statements)

References 82 publications

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“…Other research relating CRP to cognition [Kuo, Yen, et al 2005 ] [Yaffe, Lindquist, et al 2003 ] [Dik, Jonker, et al 2005 ] [Tilvis, Kahonen-Vare, et al 2004 ] [Yaffe, Lindquist, et al 2003 ] has produced conflicting results. Elevated CRP has been linked to cardiovascular disease, atherosclerosis and ischemic stroke [Ridker, Haughie 1998 ] [Kuo, Yen, et al 2005 ] [van Dijk, Prins, et al 2005 ] which are themselves associated with higher risk of cognitive impairments. We have adjusted for confounding by stroke and diabetes.…”

Section: Discussionmentioning

confidence: 99%

C-reactive protein and rate of dementia in carriers and non carriers of Apolipoprotein APOE4 genotype

Haan

Aiello

West

et al. 2008

Neurobiology of Aging

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Background-Those with an apolipoprotein APOE4 allele (APOE4) have lower C-reactive protein (CRP) than those without APOE4. Whether APOE4 modifies the effects of CRP on rate of all cause dementia, cognitive impairment or Alzheimer's disease (AD) is not established.Methods-All cause dementia and cognitive impairment without dementia (CIND) was determined over five follow up visits from 1998-2006 in an ongoing cohort of older Latinos. The association between high sensitivity CRP and dementia/CIND, all cause dementia and Alzheimer's disease by APOE4 status was examined in semi-parametric survival models with covariate adjustments.Results-CRP was significantly lower among those with APOE4 than in those without. Among those with APOE4, CRP was associated with lower rates of combined dementia/CIND (HR: 0.60, 95% CL: 0.20-0.91, p=0.03) from a fully adjusted model. Among those with no APOE4, there was no effect of CRP on dementia/CIND rates (HR: 0.94, 95% CL:0.67-1.33).Conclusions-Lower CRP in those with APOE4 may reflect immune effects of the APOE4 genotype. Higher CRP in those with APOE4 may be a marker of better immune function, leading to lower rate of dementia and AD.

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Section: Discussionmentioning

confidence: 99%

C-reactive protein and rate of dementia in carriers and non carriers of Apolipoprotein APOE4 genotype

Haan

Aiello

West

et al. 2008

Neurobiology of Aging

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“…52 Inflammation is one of the basic mechanisms in the pathogenesis of atherosclerosis and its complications. 53 On the other hand, cerebral atherosclerotic changes, stroke and leukoaraiosis in particular, may interrupt the integrity of frontal sub-cortical circuits and cause cognitive impairment and depression. 53,54,55 That is why, inflammation is supposed to be an important contributing factor in both neuronal damage after stroke and the development of amyloid plaques associated with cognitive deficit and dementia in the elderly.…”

Section: Potential Role Of Inflammation In Pre-and Post-stroke Cognitmentioning

confidence: 99%

“…53 On the other hand, cerebral atherosclerotic changes, stroke and leukoaraiosis in particular, may interrupt the integrity of frontal sub-cortical circuits and cause cognitive impairment and depression. 53,54,55 That is why, inflammation is supposed to be an important contributing factor in both neuronal damage after stroke and the development of amyloid plaques associated with cognitive deficit and dementia in the elderly. 53,56,57 Defining dementias in the elderly as neurodegenerative (Alzheimer's dementia) or vascular, respectively vascular cognitive impairment (VCI) is very difficult when assessing individual patients.…”

Section: Potential Role Of Inflammation In Pre-and Post-stroke Cognitmentioning

confidence: 99%

“…53,54,55 That is why, inflammation is supposed to be an important contributing factor in both neuronal damage after stroke and the development of amyloid plaques associated with cognitive deficit and dementia in the elderly. 53,56,57 Defining dementias in the elderly as neurodegenerative (Alzheimer's dementia) or vascular, respectively vascular cognitive impairment (VCI) is very difficult when assessing individual patients. In most cases, there is a simultaneous expression or overlapping of these states, depending on concurrent risk factors and pathophysiological mechanisms.…”

Section: Potential Role Of Inflammation In Pre-and Post-stroke Cognitmentioning

confidence: 99%

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Post-Stroke Cognitive Impairment – Phenomenology and Prognostic Factors

Danovska¹,

Stamenov²,

Alexandrova³

et al. 2012

JofIMAB

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Stroke patients are at higher risk of developing cognitive impairment. Cognitive dysfunctions, especially progressive ones, worsen stroke prognosis and outcome. A longitudinal follow-up of cognitive disorders, however, is rendered difficult by their heterogeneity and the lack of definitions generally agreed upon. Stroke is a major cause of cognitive deficit. The identification of risk factors, clinical determinants and laboratory markers of post-stroke cognitive deficit may help detect patients at increased risk of cognitive deterioration, and prevent or delay the occurrence of poststroke cognitive impairments. Though inflammatory processes have been implicated in the pathogenesis of stroke, their role in the complex pathophysiological mechanisms of post-stroke cognitive impairment is not completely understood. Evidence suggests that elevated serum Creactive protein is associated with both the increased risk of stroke and post-stroke cognitive deficit. The hypothesis of a possible relationship between markers of systemic inflammation and cognitive dysfunctions raises the question of how rational the option of applying non-steroidal antiinflammatory drugs in a proper therapeutic window will be, especially during the acute phase of stroke, to prevent cognitive decline and dementia.

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“…Furthermore, no prior study has directly evaluated the direction of the association, which remains controversial. (Kuo et al, 2005;Frasure-Smith, Lesperance, 2006) Plausible mechanisms exist for a bidirectional relationship between inflammation and depression. First, inflammation may lead to depression.…”

Section: Introductionmentioning

confidence: 99%

Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study

et al. 2008

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Background-A lack of longitudinal studies has made it difficult to establish the direction of associations between circulating concentrations of low-grade chronic inflammatory markers, such as C-reactive protein and interleukin-6, and cognitive symptoms of depression. The present study sought to assess whether C-reactive protein and interleukin-6 predict cognitive symptoms of depression or whether these symptoms predict inflammatory markers.

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Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population: systematic review and meta-analysis

Cited by 335 publications

References 82 publications

C-reactive protein and rate of dementia in carriers and non carriers of Apolipoprotein APOE4 genotype

C-reactive protein and rate of dementia in carriers and non carriers of Apolipoprotein APOE4 genotype

Post-Stroke Cognitive Impairment – Phenomenology and Prognostic Factors

Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study

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