Relation of body fat distribution to femoral neck bone density and endometrial thickness in postmenopausal women

Öktem, Özgür; Küçük, Mert; Ozer, Kamer; Sezen, Devrim; Durmuşoğlu, Fatih

doi:10.3109/09513591003632209

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…A few previous study reported that ultrasonographic EMT shows a positive correlation with BMD in postmenopausal women consistent with our results. 20 , 21 Considering mean age and proportion of postmenopausal status of this present study (52.1 ± 8.5 and 63.4%), this result was consistent with the previous studies with subjects of similar age. 22 , 23 Unlike these studies which showed this correlation with healthy postmenopausal women, this present study was conducted with breast cancer survivors.…”

Section: Discussionsupporting

confidence: 93%

Correlation between bone mineral density and endometrial thickness over time in women with breast cancer history

Lee

Kim

et al. 2021

Science Progress

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As the efficacy of chemotherapy and adjuvant endocrine therapy for breast cancer increase, the quality-of-life to cancer survivors could be more important issue in strategies of breast cancer treatment. Bone health has become more compelling in care of breast cancer survivor than ever before. This retrospective study was aimed to evaluate factors relating to the change in BMD and to ascertain the correlation between changes in BMD and EMT of women with breast cancer in follow-up. Records of 164 women who underwent surgery for breast cancer were reviewed in this study. The basal characteristics included parity, menopausal state, medication with vitamin D, bisphosphonate, selective estrogen modulator (SERM), aromatase inhibitor (AI), gonadotrophin releasing hormone agonist (GnRHa), chemotherapy, radiotherapy, cancer type including positivity of estrogen receptor, progesterone receptor and HER2, combined the other gynecologic disease or the other origin cancer. At initial and follow-up visit, all subjective were checked with BMD, endometrial thickness (EMT). The mean age was 52.1 ± 8.5 years old and overall interval between initial and follow-up visits were 17.6 ± 7.5 month in this study. The BMDs of L1–4 (1.040 ± 0.166 g/cm2 vs 1.070 ± 0.181 g/cm2, p < 0.001), femur neck (0.850 ± 0.121 g/cm2 vs 0.870 ± 0.136 g/cm2, p < 0.001), and femur total (0.902 ± 0.132 g/cm2 vs 0.915 ± 0.138 g/cm2, p < 0.001) at follow-up visit were significantly lower than those at initial visit. The change in BMDs of L1–4 ( ΔBMDL1–4, r = 0.353, p < 0.001, and r = 0.228, p = 0.003), femur neck ( ΔBMDNeck, r = 0.198, p = 0.011, and r = 0.282, p < 0.001), femur total ( ΔBMDTotal, r = 0.294, p < 0.001, and r = 0.327, p < 0.001) had positive correlation with age and the change in EMT ( ΔEMT). After age correction, ΔEMT had positive correlation with ΔBMDNeck ( r = 0.245, p = 0.002) and ΔBMDTotal ( r = 0.273, p < 0.001). ΔBMDL1–4 and ΔBMDNeck differed according to menopausal state ( p < 0.001 and p = 0.035), bisphosphonate ( p < 0.001 and p < 0.001), and GnRHa ( p < 0.001 and p < 0.001). In follow-up of women with history of breast cancer, ΔEMT could be an alternative screening marker for BMD decrease.

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Section: Discussionsupporting

confidence: 93%

Correlation between bone mineral density and endometrial thickness over time in women with breast cancer history

Lee

Kim

et al. 2021

Science Progress

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“…Warming et al [5], studied the body fat distributions of 531 healthy postmenopausal women using dual energy x-ray absorptiometry and found that visceral fat tissue was the primary factor in the production of estrone via the conversion of androgen precursors, arguing it to be the most effective fat tissue on endometrial thickness. Subsequent studies also support the notion that subcutaneous and visceral fat tissues have separate endocrinological functions [11]. Body fat distribution affects the plasma levels of sex hormones.…”

Section: Discussionmentioning

confidence: 66%

“…When an endometrial thickness of 5 mm is accepted as a cutoff value for endometrial pathology in the post-menopausal period, endometrial cancers and atypical endometrial hyperplasias can be detected with a sensitivity of 80.5% and a specifi city of 86.2% [10]. Currently, the literature includes certain studies that suggest a correlation between body fat distribution and ET, yet the role of the former in the determination of an ET greater than 5 mm remains unclear [5,7,11].…”

Section: Introductionmentioning

confidence: 99%

Are visceral adiposity index and ultrasonographic visceral fat thickness measurements correlated to endometrial thickness in postmenopausal women?

Eskicioğlu¹,

Eskicioğlu²,

Özyurt³

2019

J Gynecol Res Obstet

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Objective: During the postmenopausal period, visceral fat tissue is responsible not only for increased cardiometabolic risk, but also for endocrine function leading to increased endometrial thickness (ET). The current study aimed to 1) determine the predictive value of ultrasonographic visceral fat thickness (VFT) and the visceral adiposity index (VAI), which is defi ned as «an indicator of visceral adipose function,» for the prediction of an ET>5 mm and 2) to search for a correlation between these two measures. Materials and Methods: In 79 postmenopausal women, VFT and VAI measurements were compared between a group of patients with an ET>5 mm and a group with an ET ≤ 5 mm. The diagnostic performances of VFT and VAI were investigated. Results: There were no signifi cant differences between the two groups with respect to the VFT and VAI values. Positive correlations were observed between the VFT and VAI, as well as between VFT and ET (r=0.242, p=0.03 and r=0.217, p=0.05). Conclusion: VFT and VAI values are correlated in postmenopausal women. However, neither VFT nor VAI appears to have a predictive value for an ET>5mm. Additional studies need to be performed on this subject.

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Bone mineral density in healthy adult Indian population: the Chandigarh Urban Bone Epidemiological Study (CUBES)

et al. 2021

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Relation of body fat distribution to femoral neck bone density and endometrial thickness in postmenopausal women

Abstract: Truncal adiposity rather than overall adiposity or lean mass are more closely associated with femoral neck BMD and there is no relationship between subcutaneous fat mass and endometrial thickness in postmenopausal women.

Cited by 4 publications

References 38 publications

Correlation between bone mineral density and endometrial thickness over time in women with breast cancer history

Correlation between bone mineral density and endometrial thickness over time in women with breast cancer history

Are visceral adiposity index and ultrasonographic visceral fat thickness measurements correlated to endometrial thickness in postmenopausal women?

Bone mineral density in healthy adult Indian population: the Chandigarh Urban Bone Epidemiological Study (CUBES)

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