Relation of birth weight and childhood respiratory infection to adult lung function and death from chronic obstructive airways disease.

Barker, David J.; Godfrey, Keith M.; Fall, Caroline; Osmond, Clive; Winter, P D; Shaheen, Seif O.

doi:10.1136/bmj.303.6804.671

Cited by 790 publications

(652 citation statements)

References 20 publications

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“…If these findings are causal, they are generally consistent with the concept of "programming," which occurs when an event in a critical early period of an organism's life permanently changes its structure or function. This hypothesis has received extensive interest on the basis of accumulating evidence of a relationship between early life environmental factors and a wide range of chronic diseases, particularly hypertension and diabetes (28,29), but also, although less conclusively, obstructive lung disease (30)(31)(32). The greater influence of maternal compared with paternal asthma and atopy on the development of asthma in offspring suggests that the pre-and perinatal environment also plays a role in the subsequent development of respiratory disease in children (19,33).…”

Section: Discussionmentioning

confidence: 99%

Maternal Complications and Procedures in Pregnancy and at Birth and Wheezing Phenotypes in Children

Rusconi

Galassi

Forastiére

et al. 2007

Am J Respir Crit Care Med

138

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Rationale: There is increasing interest in the potential influence of fetal and early life conditions on childhood wheezing. Objectives: To investigate the associations between maternal complications and procedures in pregnancy and at birth and the risk of various wheezing phenotypes in young children. Methods: We studied 15,609 children, aged 6-7 yr, enrolled in a population-based study. Standardized questionnaires were completed by the children's mothers. AT A GLANCE COMMENTARY Scientific Knowledge on the SubjectMaternal smoking in pregnancy influences lung development and is associated with wheezing in childhood; other prenatal and perinatal factors (maternal infections, obstetric conditions) have been inconclusively associated with wheezing among offspring. What This Study Adds to the FieldAn association was found between maternal hypertension, diabetes, and urinary tract infections during pregnancy and exposure to antibiotics at delivery with wheezing disorders, in particular wheezing of early onset.(1). The most studied in utero environmental influence on lung development is maternal smoking in pregnancy, which has been shown to be associated not only with wheezing in childhood (2-5) but also with a dose-related reduction in lung function in the newborn period. Fetal development seems therefore to represent a critical time of pulmonary vulnerability with respect to smoking exposure. More recently, some studies have also investigated the relationships between exposure to maternal infections in pregnancy (6-8), maternal obstetric conditions (hyperemesis, hypertension, and preeclampsia) (9-11), uterine factors (antepartum hemorrhage, preterm contractions, placental insufficiency, and uterine growth restriction) (9-11), malposition or malpresentation of the fetus (11), mode of delivery (11)(12)(13)(14)(15)(16)(17)(18), and the development of asthma among offspring. However, the findings of these studies have been inconsistent.In a report published in 1999 (19), we found associations between a number of pre-, peri-, and early postnatal factors and different wheezing phenotypes in a large multicenter crosssectional population-based study, the SIDRIA (Italian Studies of Respiratory Disorders in Childhood and the Environment) phase 1 study, an extension of the International Study on Asthma and Allergies in Childhood (ISAAC) phase 1 study (20). The enrolled children were categorized, on the basis of criteria derived from Martinez and coworkers (21), as transient early wheezers (children with wheezing in the first 2 yr of life but not at school age), persistent wheezers (children who continued to wheeze at school age), late-onset wheezers (children who did not wheeze in the first years of life but who wheezed when 6-7 yr

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Section: Discussionmentioning

confidence: 99%

Maternal Complications and Procedures in Pregnancy and at Birth and Wheezing Phenotypes in Children

Rusconi

Galassi

Forastiére

et al. 2007

Am J Respir Crit Care Med

138

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“…236 development of airways and alveoli occurs in early life (37). Developmental adaptations in 238 fetal life and infancy due to early life adverse exposures might result in impaired lung growth 239 with smaller airways, decreased lung volume, and subsequently to an increased risk of 240 bronchopulmonary dysplasia, asthma or COPD (9,14,38). Previous studies suggest that 241 children with asthma already have a reduced lung function in the first months of life, and that 242 this deficit progresses into childhood and early adulthood (39,40).…”

Section: Early Growth Measures and Lung Function Outcomes 176mentioning

confidence: 99%

Early growth characteristics and the risk of reduced lung function and asthma: A meta-analysis of 25,000 children

Dekker

Voort

Jongste

et al. 2016

Journal of Allergy and Clinical Immunology

156

130

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“…In utero exposures, such as smoking, have been shown to influence the developing fetal lung (1). Variations in lung maturity and in genes known to be expressed during lung development, and birth weight, have been associated with childhood asthma, bronchopulmonary dysplasia (BPD), adult lung function, and with death from chronic obstructive airways disease in adult life (2)(3)(4). This highlights the need to understand variability in the course of prenatal lung development, as it may contain the imprint for life-long pulmonary function growth/decline, and the developmental origins of chronic lung disease.…”

mentioning

confidence: 99%

Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome

Kho

Chhabra

Sharma

et al. 2016

Am J Respir Cell Mol Biol

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The fetal origins of disease hypothesis suggests that variations in the course of prenatal lung development may affect life-long pulmonary function growth, decline, and pathobiology. Many studies support the existence of differences in the developing lung trajectory in males and females, and sex-specific differences in the prevalence of chronic lung diseases, such as asthma and bronchopulmonary dysplasia. The objectives of this study were to investigate the early developing fetal lung for transcriptomic correlates of postconception age (maturity) and sex, and their associations with chronic lung diseases. We analyzed whole-lung transcriptome profiles of 61 females and 78 males at 54-127 days postconception (dpc) from nonsmoking mothers using unsupervised principal component analysis and supervised linear regression models. We identified dominant transcriptomic correlates for postconception age and sex with corresponding gene sets that were enriched for developing lung structural and functional ontologies. We observed that the transcriptomic sex difference was not a uniform global time shift/lag, rather, lungs of males appear to be more mature than those of females before 96 dpc, and females appear to be more mature than males after 96 dpc. The age correlate gene set was consistently enriched for asthma and bronchopulmonary dysplasia genes, but the sex correlate gene sets were not. Despite sex differences in the developing fetal lung transcriptome, postconception age appears to be more dominant than sex in the effect of early fetal lung developments on disease risk during this early pseudoglandular phase of development.

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Relation of birth weight and childhood respiratory infection to adult lung function and death from chronic obstructive airways disease.

Cited by 790 publications

References 20 publications

Maternal Complications and Procedures in Pregnancy and at Birth and Wheezing Phenotypes in Children

Maternal Complications and Procedures in Pregnancy and at Birth and Wheezing Phenotypes in Children

Early growth characteristics and the risk of reduced lung function and asthma: A meta-analysis of 25,000 children

Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome

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