Relation of Baseline Serum Potassium Levels to Angiographic Findings in Patients With Known or Suspected Coronary Artery Disease

Çavuşoğlu, Erdal; Chopra, Vineet; Gupta, Amit; Choksi, Palak; Ruwende, Cyril; Yanamadala, Sunitha; Frishman, William H.; Pinsky, David J.; Marmur, Jonathan D.

doi:10.1038/ajh.2009.65

Cited by 3 publications

(7 citation statements)

References 11 publications

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“…Cavusoglu et al. suggested that serum potassium concentration is independently associated with presence of coronary artery disease. Thus, previous studies have reported the association between potassium and CVD.…”

Section: Introductionmentioning

confidence: 99%

“…Franse et al (5) suggested that the risk of CVD was lower among the patients who had normal serum potassium concentration compared with those who had low serum potassium concentration. Cavusoglu et al (6) suggested that serum potassium concentration is independently associated with presence of coronary artery disease. Thus, previous studies have reported the association between potassium and CVD.…”

Section: Introductionmentioning

confidence: 99%

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Low serum potassium concentration is a predictor of chronic kidney disease

Fukui

Tanaka

Toda³

et al. 2014

Int J Clin Pract

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Low serum potassium concentration is a predictor of chronic kidney disease

Fukui

Tanaka

Toda³

et al. 2014

Int J Clin Pract

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“…Other mechanisms explaining the role of increased potassium levels in the maintenance of normal blood pressure as well as prevention of coronary atherosclerosis are as follows; a) inhibition of platelet aggregation and arterial thrombosis; b) reduction in renal vascular resistance and increase in glomerular filtration rate; c) inhibition of free radical formation from vascular endothelial cells and macrophages; d) inhibition of vascular smooth muscle cell proliferation; and e) suppression of reactive oxygen species overproduction [23]. Such established findings are in contradiction to two previous studies [11,12] which have reported that hyperkalemia is associated with increased atherosclerosis. Multiple factors can affect serum potassium levels including renal function, dietary intake, hormonal status, renin-angiotensin-aldosterone system, heart failure, myocardial infarction and drugs.…”

Section: Discussionmentioning

confidence: 65%

“…Moreover, animal studies have shown that high potassium diets normalize blood pressure and provide protection against atherosclerosis in arteries [22]. Increased potassium content in diets plays a role reduction of vascular lesions owing to decreased endothelial injuries and less adherence and infiltration of macrophages into the vascular wall [11].…”

Section: Discussionmentioning

confidence: 99%

“…However, a few recent studies [11,12] have demonstrated the correlation between elevated serum potassium levels and increased atherosclerosis as well as the severity of coronary artery disease, which would contradict the above-given explanations. So, keeping in mind the results of such studies, we hypothesized that lower serum potassium may be associated with an increased risk of cardiovascular events and mortality.…”

Section: Introductionmentioning

confidence: 98%

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Prognostic significance of serum potassium level for major adverse cardiac events and death in patients with coronary atherosclerotic disease

Altaf

Alam

Salahuddin³

et al. 2020

Acta Angiologica

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Introduction: Serum potassium levels have been shown in some animal studies to be associated with the process of atherosclerosis. We decided to assess the correlation of serum potassium level in ischemic heart disease patients with disease severity and its relationship with prognosis in terms of major acute cardiac events (MACE). Material and methods: This was a cross-sectional cohort study carried out at cardiology department of Rehman Medical Institute, from July 2016 to 31 st Aug. 2018 a period of 26 months. 622 patients were included in the study. Clinical and angiographic characteristics were assessed based on the serum potassium level. Correlation of serum potassium level with Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) and Gensini scores was also evaluated. Follow up for MACE was carried out after one year. Results: Mean serum potassium level was 3.93 ± 0.95 (mEq/l) in coronary artery disease patients. Serum potassium level showed negative correlation with SYNTAX score (r =-0.60, p < 0.05) and Gensini score (r =-0.64, p < 0.05). There was also a significant difference between low and high potassium level in relation to the multi-vessel disease on coronary angiography (p < 0.05). Low potassium level was a good predictor of adverse outcomes as shown by Kaplan-Meier analysis. Multivariate Cox regression analysis showed that serum potassium level and diabetes were independent predictors of MACE (p < 0.05). Conclusion: Low serum potassium level is correlated with more severe coronary atherosclerosis. Low potassium levels are associated with significantly poor outcomes.

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Variations in Post-Operative Electrolyte in Coronary Artery Intervention

Fan,

Bai,

Ndjana Lessomo

et al. 2023

IJGM

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Background: Low volume change and minimal trauma observed during angiography are the reason why physicians often overlook any changes affecting pre-operative electrolytes levels after coronary intervention. However, few studies have addressed the issue of electrolyte changes after the coronary intervention. Therefore, our study investigates coronary angiography's effect on electrolytes and provides the quick identification of groups more prone to electrolyte changes. Methods: From the department of cardiology of the second affiliated hospital of Shandong's first medical university, 374 patients undergoing coronary angiography were selected. Pre-intervention and post-intervention serums, sodium (Na + ), potassium (K + ), chloride (Cl − ), magnesium (Mg 2+ ) and renal function were analyzed. The correlation between influential factors was also assessed. The association of hypokalemia with short-major adverse cardiac events (MACE) and arrhythmia was evaluated. Results: Among the 374 subjects including 264 patients who had a simple angiography and 110 patients who received coronary artery interventional therapy. A decrease in potassium levels was found in 81.8% of the patients, and post-interventional hypokalemia was observed in 15.0%. After the intervention, the hypokalemia among males was 2.18 times than that of females, and the pre-operative serum potassium level was 3.5mmol/L≤K + <4.0mmol/L and was 2.09 times than that of K + ≥4.0 mmol/L, but was not associated with age and either simple coronary angiography or PCI (percutaneous coronary intervention). Hypernatremia was also prevalent in males under 60 years and with pre-operative hypernatremia. Significant variations were found between hypokalemia and influential factors like hypertension, diabetes, and gastrointestinal disease. We also found that there was no obvious correlation between hypokalemia and recurrent angina, heart failure and death, but significantly increased the risk of some arrhythmias. Conclusion:Male patients are more likely to suffer from electrolyte disturbance after coronary intervention. There is a need to emphasize monitoring and managing electrolyte changes to prevent severe complications in the peri-operative period.

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Relation of Baseline Serum Potassium Levels to Angiographic Findings in Patients With Known or Suspected Coronary Artery Disease

Abstract: These data demonstrate that a simple baseline serum potassium level is independently associated with the presence of multivessel disease, even in the context of clinical CAD risk factors and other established inflammatory markers.

Cited by 3 publications

References 11 publications

Low serum potassium concentration is a predictor of chronic kidney disease

Low serum potassium concentration is a predictor of chronic kidney disease

Prognostic significance of serum potassium level for major adverse cardiac events and death in patients with coronary atherosclerotic disease

Variations in Post-Operative Electrolyte in Coronary Artery Intervention

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