Relation of Atrial and/or Ventricular Premature Complexes on a Two-Minute Rhythm Strip to the Risk of Sudden Cardiac Death (the Atherosclerosis Risk in Communities [ARIC] Study)

Cheriyath, Pramil; He, Fan; Peters, Ian; Li, Xian; Alagona, Peter; Wu, Chuntao; Pu, Min; Cascio, Wayne E.; Liao, Duanping

doi:10.1016/j.amjcard.2010.09.002

Cited by 62 publications

(49 citation statements)

References 14 publications

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“…In comparison, the studies included in the meta-analysis had high cardiovascular risk profile. For example, 44% of patients in Cheriyath's22 sample were hypertensives; 24% of Bikkina's19 study population were hypertensive; 40% of Kennedy's12 population were smokers and dyslipidaemic and 34% of Abdalla's17 sample were smokers.…”

Section: Resultsmentioning

confidence: 99%

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The prognostic significance of premature ventricular complexes in adults without clinically apparent heart disease: a meta-analysis and systematic review

Lee

Hemingway

Harb

et al. 2012

Heart

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Most studies on PVC prognosis in 'normal hearts' did not use advanced tests to rule out structural heart disease. Among these patients, PVCs are associated with a worse cardiovascular outcome if patients are older and have higher cardiovascular risk, suggesting that the poor prognosis studies may have inadvertently included patients with occult structural heart disease, the population in which PVCs are known to confer adverse outcomes.

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Section: Resultsmentioning

confidence: 99%

“…For example, where Massing et al ,25 2006 and Cheriyath et al ,22 2011 used the same ARIC (Atherosclerosis Risk in Communities) database, only Cheriyath's study was included in the meta-analysis. Bikkina et al 19 and Hirose et al 21 analysed male and female patients separately.…”

Section: Methodsmentioning

confidence: 99%

The prognostic significance of premature ventricular complexes in adults without clinically apparent heart disease: a meta-analysis and systematic review

Lee

Hemingway

Harb

et al. 2012

Heart

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“…On the other hand, data from atherosclerosis in communities (ARIC) cohort showed conflicting results regarding APC’s on a 2 minute rhythm strip and mortality 9 . We speculate that the difference might be because of increased sensitivity of 2 minute versus 10 seconds (ordinary ECG) in picking up APC’s.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Mortality Risk in Individuals With Atrial or Ventricular Premature Complexes (Results from the Third National Health and Nutrition Examination Survey)

Qureshi

Shah

Salahuddin

et al. 2014

The American Journal of Cardiology

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Premature ectopic beats are frequently detected on routine 12-lead screening-electrocardiogram (ECG). However, their prognostic importance in individuals without known cardiovascular disease (CVD) is not well established. We evaluated prognostic value of atrial premature complexes (APC’s) and ventricular premature complexes (VPC’s) detected by a single 12-lead-ECG. A prospective cohort of 7504 participants selected from nationally-representative, community-dwelling individuals living in United States, enrolled in the Third Health and Nutrition Examination Survey (NHANES-III) from 1988 – 94 with follow up through December 2006 without known CVD. The main outcomes were all – cause mortality, CVD related mortality and IHD related mortality. Out of 7504 participants (mean age 60 ± 14 years, 47% women, 49% whites), 89 (1.2%) had APC’s and 110 (1.5%) had VPC’s on 12 – lead ECG. During a follow up of up to 18 years, 2386 deaths occurred, of which 963 were due to CVD and 511 were due to IHD. In a multivariable adjusted for demographics, clinical variables and ECG measures, APC’s were significantly associated with all-cause mortality [HR, 1.41 (95% CI, 1.08–1.80)], CVD death [HR, 1.78 (95% CI, 1.26–2.44)] and IHD death [HR, 2.40 (95% CI, 1.59–3.47)]. For VPCs, however, there were no significant associations with all – cause mortality [HR, 1.05 (95% CI, 0.80–1.36)], CVD death [HR, 0.96 (95% CI, 0.62–1.43)] and IHD death [HR, 0.89 (95% CI, 0.47–1.52)]. In conclusion, APC’s, but not VPC’s, on routine screening ECG are predictive of adverse events in community-dwelling individuals without known CVD.

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“…To our knowledge, only one previous study investigated complex ventricular arrhythmia in nondialysis CKD patients and found a prevalence of 17% [5], which is similar to our data. Considering that the prevalence of simple ventricular premature complexes is only 3.8-5.4% in general populations with a similar age distribution as our cohort [14,15], these results suggest that complex arrhythmias are approximately 3- to 5-fold more common in CKD stage 2-5 patients not undergoing dialysis. …”

Section: Discussionmentioning

confidence: 87%

Asymptomatic Ventricular Arrhythmia and Clinical Outcomes in Chronic Kidney Disease: A Pilot Study

Bonato¹,

Watanabe²,

Lemos³

et al. 2016

Cardiorenal Med

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Background/Aims: Ventricular arrhythmia is associated with increased risk of cardiovascular events and death in the general population. Sudden death is a leading cause of death in end-stage renal disease. We aimed at evaluating the effects of ventricular arrhythmia on clinical outcomes in patients with earlier stages of chronic kidney disease (CKD). Methods: In a prospective study of 109 nondialyzed CKD patients (estimated glomerular filtration rate 34.8 ± 16.1 ml/min/1.73 m², 57 ± 11.4 years, 61% male, 24% diabetics), we tested the hypothesis that the presence of subclinical complex ventricular arrhythmia, assessed by 24-hour electrocardiogram, is associated with increased risks of cardiovascular events, hospitalization, and death and with their composite outcome during 24 months of follow-up. Complex ventricular arrhythmia was defined as the presence of multifocal ventricular extrasystoles, paired ventricular extrasystoles, nonsustained ventricular tachycardia, or R wave over T wave. Results: We identified complex ventricular arrhythmia in 14% of participants at baseline. During follow-up, 11 cardiovascular events, 15 hospitalizations, and 4 deaths occurred. The presence of complex ventricular arrhythmia was associated with cardiovascular events (p < 0.001), hospitalization (p = 0.018), mortality (p < 0.001), and the composite outcome (p < 0.001). In multivariate Cox regression analysis, adjusting for demographic characteristics, complex ventricular arrhythmia was associated with increased risk of the composite outcome (HR 4.40; 95% CI 1.60-12.12; p = 0.004). Conclusion: In this pilot study, the presence of asymptomatic complex ventricular arrhythmia was associated with poor clinical outcomes in nondialyzed CKD patients.

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Relation of Atrial and/or Ventricular Premature Complexes on a Two-Minute Rhythm Strip to the Risk of Sudden Cardiac Death (the Atherosclerosis Risk in Communities [ARIC] Study)

Cited by 62 publications

References 14 publications

The prognostic significance of premature ventricular complexes in adults without clinically apparent heart disease: a meta-analysis and systematic review

The prognostic significance of premature ventricular complexes in adults without clinically apparent heart disease: a meta-analysis and systematic review

Long-Term Mortality Risk in Individuals With Atrial or Ventricular Premature Complexes (Results from the Third National Health and Nutrition Examination Survey)

Asymptomatic Ventricular Arrhythmia and Clinical Outcomes in Chronic Kidney Disease: A Pilot Study

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