Relation of Anxiety and Depressive Symptoms to Coronary Artery Calcium (from the ELSA-Brasil Baseline Data)

Bittencourt, Márcio Sommer; Rocco, Piazza; Pereira, Alexandre C.; Barreto, Sandhi Maria; Brunoni, André R.; Goulart, Alessandra Carvalho; Blaha, Michael J.; Lotufo, Paulo A.; Santos, Itamar S.

doi:10.1016/j.amjcard.2016.04.048

Cited by 15 publications

(4 citation statements)

References 29 publications

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“…Depression has not been associated with hypertension, although, it is an important finding, since data from the Longitudinal Adult Health Study (ELSA) have indicated that psychopathological symptoms were directly associated with atherosclerosis and this association appeared to be stronger in people with more than 50 years of age (29) , age profile similar to that of the present study. Such associations are important to understand the relationship between cardiovascular diseases and psychopathological symptoms.…”

Section: Discussionsupporting

confidence: 63%

Hypertension is the underlying cause of death assessed at the autopsy of individuals

Coelho

Ferretti-Rebustini

Suemoto

et al. 2019

Rev. esc. enferm. USP

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Objective: To analyze hypertension and its relationship with the causes of death identified by the autopsy. Method: Cross-sectional study analyzed 356 participants belonging to the Brazilian Aging Brain Study Group, over 50 years of age, autopsied at the Sao Paulo Autopsy Service between 2004 to 2014. A clinical interview was conducted with the informant of the deceased. Hypertension was defined by reporting the disease and/or use of antihypertensive medication, by the informant of the deceased. Descriptive analyzes and bivariate and multivariable associations were performed. Results: The prevalence of hypertension was 66.2% and it was the second leading cause of death (25.6%) identified by autopsy, preceded by atherosclerosis (37.8%). The variables associated with hypertension were: female gender (OR=2.30 (1.34-3.90)); living with partner [OR=0.55 (0.32-0.92)]; Body Mass Index [OR=1.14 (1.08-1.22)] and history of diabetes [OR=2.39 (1.34-4.27)]. Conclusion: The prevalence of hypertension was high, and it was the second most common underlying cause of death. The gold standard for the definition of cause of death, the autopsy, shows important results, which confirmed the relevance of hypertension as a public health problem.

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Section: Discussionsupporting

confidence: 63%

Hypertension is the underlying cause of death assessed at the autopsy of individuals

Coelho

Ferretti-Rebustini

Suemoto

et al. 2019

Rev. esc. enferm. USP

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“…For instance, a recent large‐scale meta‐analysis of over 3 million patients showed that patients with severe mental illness, including schizophrenia, bipolar disorder, and depression, present a significantly increased risk of CVD, such as coronary heart disease, cerebrovascular disease, and congestive heart failure, and CVD‐related mortality . The association between depression, CVD, and CVD mortality might be mediated by several biological and behavioral mechanisms and risk factors, such as sedentary behavior , poor adherence to lifestyle changes and clinical treatment , decreased heart rate variability, higher coronary artery calcium scores, higher intima‐media thickness , and a higher prevalence of coronary heart disease .…”

Section: Discussionmentioning

confidence: 99%

Association between ideal cardiovascular health and depression incidence: a longitudinal analysis of ELSA‐Brasil

Brunoni

Szlejf

Suemoto

et al. 2019

Acta Psychiatr Scand

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IM. Association between ideal cardiovascular health and depression incidence: a longitudinal analysis of ELSA-Brasil.Objective: We investigated whether ideal cardiovascular health (ICH), a metric proposed by the American Heart Association, predicts depression development. Methods: Cohort analysis from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Adults with no current depression and other common mental disorders, cardiovascular diseases, and antidepressant drug use at baseline had their ICH (composite score of smoking, dietary habits, body mass index, blood pressure, fasting glucose, cholesterol, and physical activity) assessed and classified into poor, intermediate, and optimal. Depression was assessed using the Clinical Interview Schedule-Revised (CIS-R). Poisson regression models, adjusted for sociodemographic factors and alcohol consumption, were employed. Stratified analyses were performed for age and sex. Results: We included 9214 participants (mean age 52 AE 9 years, 48.6% women). Overall depression incidence at 3.8-year follow-up was 1.5%. Intermediate and poor ICH significantly increased the risk rate (RR) of developing depression (2.48 [95%CI 1.06-5.78] and 3 [1.28-7.03], respectively) at a 3.8-year follow-up. Higher ICH scores decreased the rate of depression development (RR = 0.84 [0.73-0.96] per metric). Stratified analyses were significant for women and adults < 55 years old. Conclusions: Poor cardiovascular health tripled depression risk at follow-up in otherwise healthy adults. Ameliorating cardiovascular health might decrease depression risk development. Significant outcomes• Poor cardiovascular health predicts depression incidence in subjects free of mental and cardiovascular disorders.• These effects are more pronounced in women and in subjects younger than 55 years old. • Decreasing cardiovascular risk can impact in both clinical and mental outcomes. Limitations• The follow-up period was relatively small (3.8 years).• Other common mental disorders were not examined. 552

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“…13 The baseline evaluation of ELSA-Brasil revealed that anxiety was related to prevalent cardiovascular diseases, 14 to subclinical atherosclerosis (as measured from the intimal-media thickness of the common carotid artery) 15 and to coronary calcification. 16 Moreover, prescription of medicines for mental disorders was associated with low heart rate variability, which is a marker of adverse health outcomes. 17 The frequency of depression was correlated with presence of diabetes.…”

Section: Researchers Working On the Brazilian Longitudinal Study Ofmentioning

confidence: 99%

Mental disorders and heart diseases: from William Harvey to today

Lotufo

2017

Sao Paulo Med. J.

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Relation of Anxiety and Depressive Symptoms to Coronary Artery Calcium (from the ELSA-Brasil Baseline Data)

Cited by 15 publications

References 29 publications

Hypertension is the underlying cause of death assessed at the autopsy of individuals

Hypertension is the underlying cause of death assessed at the autopsy of individuals

Association between ideal cardiovascular health and depression incidence: a longitudinal analysis of ELSA‐Brasil

Mental disorders and heart diseases: from William Harvey to today

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