Relation of Antioxidant Native Thiol Level with Inflammatory Markers and Disease Activity Index in Pediatric Ulcerative Colitis

Abstract

Objective: Pediatric ulcerative colitis (PUC) is an inflammatory disease. PUC pathogenesis is associated with an imbalance between reactive oxygen species and antioxidant activity which creates oxidative stress. Native thiol (NT) level is antioxidant capacity which is practical and repeatable marker of inflammation and antioxidan level. We aimed to analyse the relation of NT level with inflammatory markers and pediatric ulcerative colitis activity index (PUCAI). Material and Methods: Thirty-eight PUC patients (SG) and 33 control group (CG) participants were included in the study. PUC patients grouped as in remission, mild, moderate and severe activity according to disease activity according to PUCAI. NT, hemoglobin (Hb), white blood cell (WBC), platelet (PLT), mean platelet volume (MPV), albumin, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin 6 (IL-6) levels of all participants were measured at the time they were enrolled in the study and recorded. Results: Mean age and gender ratio of groups were similar (p>0.050). NT level of SG statistically high compared to CG (p=0.001). Hb, PLT, MPV, CRP, ESR, IL-6 levels of SG were statistically different than CG (p=0.045, p=0.026, p=0.001, p=0.001, p=0.001, p=0.001). NT level of SG was positively correlated with Hb, MPV, albumin (p=0.001, for all). NT level of SG was negatively correlated with PLT, CRP, ESR, IL-6 and PUCAI (p=0.001). Conclusion: NT level of PUC is significantly lower than CG. NT level of SG was positively correlated with albumin which is a good prognostic factor in PUC patients. NT may be repeatable, noninvasive candidate serum biomarker for PUC management.