Relation of Adenomatous Hyperplasia of the Gastric Mucosa to Carcinogenesis

Schauer, A.; Kunze, Ekkehard

doi:10.1016/s0344-0338(79)80046-1

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…Unter Berficksichtigung unterschiedlicher histologischer Kriterien sprechen alle Ergebnisse der bisher voliegenden tierexperimentellen Arbeiten zur Carcinomentstehung im operierten Magen ffir eine eindeutige Beziehung der Magenoperation zu einem Carcinom im operierten Magen als Operationsfolge [3,15,20,23].…”

Section: Histoautoradiographic Investigations In the Resected Stomachunclassified

“…Die Signifikanz der adenomat6s-cystischen Proliferation in bezug aufdas Problem der Carcinomentstehung im Magen-Darm-Trakt wird in der Literatur gegens~itzlich interpretiert [20,23,26]. Die Signifikanz der adenomat6s-cystischen Proliferation in bezug aufdas Problem der Carcinomentstehung im Magen-Darm-Trakt wird in der Literatur gegens~itzlich interpretiert [20,23,26].…”

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Histoautoradiographische Untersuchungen im Billroth-I-operierten Rattenmagen in Abh�ngigkeit vom postoperativen Intervall

Meyer¹,

Schlake²,

Nomura³

1985

Langenbecks Arch Chiv

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In a postoperative interval of 104 weeks' experience with 75 Wistar rats resected according to Billroth's 1st principle, the fourfold of standard of proliferative activity in addition to extended displacements and decompositions could be demonstrated. During 104 weeks of experience 8 animals developed in the anastomosed mucosa section adenomatous cystic glandular proliferations, 5 animals anastomotic polypi, 16 animals dysplastic gland areas and 10 animals showed anastomotic carcinomas. For these pathologic-anatomically outlined changes cellular proliferation was analysed by histoautoradiographic methods in parts of highest mitotic activity. The results were interpreted in dependence on their postoperative interval. In all pathologic-anatomical changes sources of strongest labelling could be found in the periphery. As most serious complication rats in experiment developed carcinoma in the anastomosed parts of mucosa. The peripheral sections of the carcinoma, so-called "front of invasion", showed regions of highest mitotic activity. Analysis of histoautoradiographic investigation in pathologic-anatomical change revealed modified proliferation kinetics in the sense of highly increased cell proliferation rates, which refer to the important role of the anastomotic region in the resected stomach.

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Section: Histoautoradiographic Investigations In the Resected Stomachunclassified

Section: Diskussionunclassified

Histoautoradiographische Untersuchungen im Billroth-I-operierten Rattenmagen in Abh�ngigkeit vom postoperativen Intervall

Meyer¹,

Schlake²,

Nomura³

1985

Langenbecks Arch Chiv

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Early sequential lesions during development of experimental gastric cancer with special reference to dysplasias

Kunze

Schauer

Eder

et al. 1979

J Cancer Res Clin Oncol

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The early sequential development of gastric cancer was studied with experimental animals and examined with respect to what conclusions can be drawn for understanding carcinogenesis in man. After limited oral administration of N-methyl-N'nitro-N-nitrosoguanidine to 174 rats carcinomas developed in most cases directly from the otherwise unchanged mucosa through various successive stages of transformation, without passing through a benign-appearing proliferative or neoplastic epithelial lesion. Focal dysplasia grade I was the first recognizable change observed by light microscopy, followed by dysplasia grade II, and subsequently dysplasia grade III. In spite of very similar morphological characteristics, the experimentally induced dysplasias cannot be simply equated in their etiology and biological behavior with the dysplasias of the human stomach. Dysplasias of grade I and II commonly found in man are usually associated with a chronic gastritis; they are located in the upper third of the mucosa and are for the most part reversible. The experimental dysplasias occuring in the proliferative zone of an otherwise undisturbed mucosa must be considered potentially premalignant, as they are irreversible and develop progressively. This finding points out that in man dysplasias grade III within the regenerative zone of non-inflammatory mucosa should be considered particularly as possible precursors of gastric carcinomas.

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Gastrointestinal Stem Cells and Their Role in Carcinogenesis

Bykorez¹,

Ivashchenko²

1984

International Review of Cytology

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Relation of Adenomatous Hyperplasia of the Gastric Mucosa to Carcinogenesis

Cited by 5 publications

References 9 publications

Histoautoradiographische Untersuchungen im Billroth-I-operierten Rattenmagen in Abh�ngigkeit vom postoperativen Intervall

Histoautoradiographische Untersuchungen im Billroth-I-operierten Rattenmagen in Abh�ngigkeit vom postoperativen Intervall

Early sequential lesions during development of experimental gastric cancer with special reference to dysplasias

Gastrointestinal Stem Cells and Their Role in Carcinogenesis

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