Relation of ABO blood groups to coronary lesion complexity in patients with stable coronary artery disease

Abstract

Author`s ReplyTo the Editor,We would like to thank the authors of the letter for their interest and criticism about our study published in February issue of The Anatolian Journal of Cardiology 2014; 14: 55-60 (1). The relation between ABO blood groups and coronary artery disease is known for many years. But, there are no adequate information about the causes of relation between ABO blood groups and coronary artery diseases. In our study, we tried to discuss the relation between ABO blood groups and the development of coronary artery diseases, also we discussed the mechanism of coagulation attributing vWF and lipid metabolism of ABO blood groups (1). The author summarized the relation between blood groups and CAD in different races (2-5) and wanted our explanation of what might be the causes of variations between our study and the other studies. First of all, it is known that risk factors in the development of coronary artery diseases are different in different races. These differences are claimed to be both genetic and environmental reasons. We think that the variations between these studies and our study as well as these studies each other could be related to both genetic and environmental reasons. Secondly, authors wanted to learn the relation between lipid levels and ABO blood groups. We have re-analyzed our data and HDL (41±12 vs. 40±14), LDL (93±37 vs. 87±36), TG (135±128 vs. 129±131) did not differ between 0 and non 0 groups. However, Chen et al. (3) determined a significant relation between ABO blood groups and lipid levels as noted by the authors. We can list the possible causes of these differences: Both studies were conducted in different races (Turkish vs Chinese), while there were more than 6 thousand patients in the Chen et al. (3) study, there were about 500 patients in our study. In addition in our study 15-20% patients had a history of statin use. All these reasons may explain the differences between the two studies.

Relation of ABO Blood Groups to the Plaque Characteristic of Coronary Atherosclerosis

“…Recent metastudy also confirmed that non-O blood group appears to be an independent risk factor for CAD and myocardial infarction, and non-O blood group was associated with a statistically significant 14% increase in CAD incidence relative to O blood group [ 4 ]. Moreover, clinical data on the association of ABO blood groups with severity of CAD have shown that ABO blood groups were significantly related to severity of CAD, non-O blood group was found to be the independent predictors of high SYNTAX score [ 5 ], and O blood group was shown as a protective factor of high Gensini score [ 6 ].…”

Is There Any Relationship between ABO Blood Groups and Coronary Ectasia?

“…However, there are conflicting results in the literature. In one study, no relationship between ABO blood groups and CAD was shown [19]. In addition, another study showed that ABO blood groups dsitributions were similar in patient with CAD [20].…”