Relation of 25-hydroxyvitamin D and parathyroid hormone levels with metabolic syndrome among US adults.

Reis, Jared P.; Mühlen, Denise von; Miller, Edgar R.

doi:10.1530/eje-08-0072

Cited by 182 publications

(198 citation statements)

References 46 publications

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“…Many studies showed that in patients with metabolic syndrome, vitamin D level is lower, while some other studies rejected this hypothesis. In a study on 1654 Americans, [24][25][26] the lower levels of vitamin D was observed in patients with metabolic syndrome; the result was in agreement with those of some other studies. In a study by Moy on 380 individuals, subjects with vitamin D deficiency were at higher risk for the development of metabolic syndrome (OP = 1.73); in addition, BMI, waist circumference, and TG level were significantly different among the ones with normal and vitamin D deficiency [27].…”

Section: Discussionsupporting

confidence: 90%

Association of Serum Vitamin D Level and Serum Lipids Profile

Sadeghi

Eidi

Zamani

2018

ijcp

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Introduction: High level of vitamin D is associated with a better health status. The role of vitamin D deficiency in the incidence of cardiovascular events is demonstrated in previous studies. The current study aimed at evaluating the effect of vitamin D supplement therapy on serum lipids profile, as a risk factor for cardiovascular diseases. Methods: The current prospective cohort study included 221 patients admitted to a university hospital from March 2014 to March 2015. The baseline levels of the patients′ serum vitamin D and lipid profile of the study subjects were recorded. After three months treatment with vitamin D, the patients′ serum vitamin D level and lipid profile were reevaluated. The results before and after the supplement therapy were compared using statistical methods. Results: The mean age of the patients was 48.2 ± 14.0 years. The mean vitamin D level was 21.0 ± 16.6 ng/mL at baseline, which increased to 35.8 ± 32.7 ng/mL (P = 0.001) after a three-month vitamin D supplement therapy. Mean low-density lipoprotein (LDL) decreased from 112.1 ± 30.0 to 98.7 ± 31.7 mg/dL (P = 0.003) after the supplement therapy. Mean high-density lipoprotein (HDL) increased from 42.8 ± 11.2 to 44.5 ± 9.0 mg/dL, but the difference was insignificant before and after the treatment (P = 0.2). Mean cholesterol reduced from 183.8 ± 42.3 to 169.5 ± 41.9 mg/dL (P = 0.02) and the mean TG dropped from 147.5 ± 98.7 to 134.7 ± 71.1 mg/dL, (P = 0.1) after vitamin D intake. Conclusions:The mean levels of LDL and cholesterol significantly decreased during the three-month intervention; in addition, although some changes were observed in the level of HDL and TG, the differences were statistically insignificant. Further studies on larger sample sizes and longer follow-ups are recommended.

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Section: Discussionsupporting

confidence: 90%

Association of Serum Vitamin D Level and Serum Lipids Profile

Sadeghi

Eidi

Zamani

2018

ijcp

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“…Several studies reported that 25(OH)D 3 was inversely related to percentage body fat (37,38), elevated BP (39-41), elevated glucose or IR (11,(42)(43)(44), and triglycerides (45) and positively associated with HDL-cholesterol (42). In particular, using data from the Third National Health Examination and Nutrition Survey (NHANES) (46). However, the explanation of the inverse associations of metabolic derangements with deficiency of vitamin D is very complex.…”

Section: Discussionmentioning

confidence: 99%

Low 25(OH)D3 levels are associated with total adiposity, metabolic syndrome, and hypertension in Caucasian children and adolescents

Pacifico

Anania

Osborn

et al. 2011

European Journal of Endocrinology

161

122

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Objectives: Evidence of the association between vitamin D and cardiovascular risk factors in the young is limited. We therefore assessed the relationships between circulating 25-hydroxyvitamin D 3 (25(OH)D 3 ) and metabolic syndrome (MetS), its components, and early atherosclerotic changes in 452 (304 overweight/obese and 148 healthy, normal weight) Caucasian children. Methods: We determined serum 25(OH)D 3 concentrations in relation to MetS, its components (central obesity, hypertension, low high-density lipoprotein (HDL)-cholesterol, hypertriglyceridemia, glucose impairment, and/or insulin resistance (IR)), and impairment of flow-mediated vasodilatation (FMD) and increased carotid intima-media thickness (cIMT) -two markers of subclinical atherosclerosis. Results: Higher 25(OH)D 3 was significantly associated with a reduced presence of MetS. Obesity, central obesity, hypertension, hypertriglyceridemia, low HDL-cholesterol, IR, and MetS were all associated with increased odds of having low 25(OH)D 3 levels, after adjustment for age, sex, and Tanner stage. After additional adjustment for SDS-body mass index, elevated blood pressure (BP) and MetS remained significantly associated with low vitamin D status. The adjusted odds ratio (95% confidence interval) for those in the lowest (!17 ng/ml) compared with the highest tertile (O27 ng/ml) of 25(OH)D 3 for hypertension was 1.72 (1.02-2.92), and for MetS, it was 2.30 (1.20-4.40). A similar pattern of association between 25(OH)D 3 , high BP, and MetS was observed when models were adjusted for waist circumference. No correlation was found between 25(OH)D 3 concentrations and either FMD or cIMT. Conclusions: Low 25(OH)D 3 levels in Caucasian children are inversely related to total adiposity, MetS, and hypertension.

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“…Further analysis of the mechanisms by which 25(OH)D and the IGF-1 and IGF binding proteins interact is warranted to discover their influence on insulin and glucose secretion and/or sensitivity. Another recent cross-sectional analysis of 1654 men and women reported a substantially lower OR for the MetS in the highest quintile of s25(OH)D (median 88·0 nmol/l; OR 0·15) compared with the lowest quintile (median 26·8 nmol/l; OR 0·46) (39) (40 -42) . McGill et al (41) showed in 243 obese adults, 80 % of whom were women (age 47·6 (SD 12) years), that while s25(OH)D concentration was inversely associated with waist circumference, BMI and HbA 1c , there was no association with the MetS.…”

Section: Cardiometabolic Syndromementioning

confidence: 97%

“…Low vitamin D status has been associated with an increased risk of the MetS (Ford et al (11) ; Forouhi et al (37) ; Hypponen et al (38) ; Reis et al (39) ; S Muldowney, A Lucey, G Paschos, et al, unpublished results; M Kiely, S Muldowney, TR Hill, et al, unpublished results). Using data from National Health and Nutrition Examination Survey (NHANES) III in almost 8500 adults (aged $ 20 years), Ford et al (11) observed subjects in the lowest quintile of s25(OH)D (# 48·4 nmol/l) were twice as likely to have the MetS compared with those in the highest quintile ($ 96·4 nmol/l).…”

Section: Cardiometabolic Syndromementioning

confidence: 99%

Vitamin D and cardiometabolic health: a review of the evidence

Muldowney

Kiely

2010

Nutr. Res. Rev.

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The cardiometabolic syndrome (MetS) is a clustering of related metabolic abnormalities including abdominal adiposity, insulin resistance, hypertension, dyslipidaemia and increased inflammatory and thrombotic markers, which is linked to increased risk of type 2 diabetes, CVD and overall mortality. Several cross-sectional and prospective studies have shown an association between low vitamin D status, as indicated by concentrations of serum 25-hydroxyvitamin D (s25(OH)D), and increased prevalence of the MetS and individual CVD risk factors. These epidemiological observations are supported by mechanistic studies but experimental data are limited. The available data from intervention studies are largely confounded as most vitamin D supplementation trials were mainly carried out to explore the role of Ca in CVD and include Ca in the treatment arms. Inadequate consideration of seasonal effects on s25(OH)D concentrations is also a common design flaw in most studies. Further complications arise from shared risk factors such as adiposity and ageing, which predispose individuals to exhibit both a more pronounced risk profile and relatively lower s25(OH)D concentrations. In conclusion, while epidemiological associations are promising and a rationale for low vitamin D status as a potentially modifiable risk factor for CVD is supported by mechanistic data, suitable experimental data from appropriately designed trials are just beginning to emerge. As yet, this body of literature is too immature to draw firm conclusions on the role of vitamin D in CVD prevention. Carefully controlled vitamin D trials in well-described population groups using intervention doses that are titrated against target s25(OH)D concentrations could yield potentially valuable outcomes that may have a positive impact on CVD risk modification.

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Relation of 25-hydroxyvitamin D and parathyroid hormone levels with metabolic syndrome among US adults.

Cited by 182 publications

References 46 publications

Association of Serum Vitamin D Level and Serum Lipids Profile

Association of Serum Vitamin D Level and Serum Lipids Profile

Low 25(OH)D3 levels are associated with total adiposity, metabolic syndrome, and hypertension in Caucasian children and adolescents

Vitamin D and cardiometabolic health: a review of the evidence

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