Relation between Trypanocidal and Spirocheticidal Activities of Neoarsphenamine: III. Uniformity of Effect of Different Types of Neoarsphenamine on the Serological Reactions in Human Syphilis

The Relation between the Trypanocidal and Spirocheticidal Activities of Neoarsphenamine: V. The Spirocheticidal Activity of the Several American Brands of Neoarsphenamine

“…In previous reports (1,2,3,4) on the relation between the trypanocidal and spirocheticidal activities of neoarsphenamine, evidence was presented which indicated that the former test should not be accepted as a reliable index of the therapeutic efficiency in experimental syphilis in rabbits. In these studies it was shown that two brands of neoarsphenamine, representing two types (5) of this drug, varying in trypanocidal activity, were remarkably uniform in spirocheticidal activity as determined by the therapeutic dose (1), prophylactic dose (2), and sterilizing dose (4), and showed no significant difference in their ability to influence the reacting substances in sera from cases of syphilis in man (3).…”