Relation Between the Middle Hepatic Vein Drainage Area Volume and Alanine Aminotransferease After Left Liver Harvesting

Kaneko, Junichi; Sugawara, Yasuhiko; Sato, Shizou; Kishi, Yoji; Akamatsu, Nobuhisa; Togashi, Junichi; Makuuchi, Masatoshi

doi:10.1016/j.transproceed.2005.03.012

Cited by 5 publications

(7 citation statements)

References 6 publications

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“…31,32 Independently of the extent of liver resection, any venous outflow limitation not compensated by the development of collaterals veins implied an arterial regurgitation in the portal branches of the congested area. [33][34][35] This situation explained PVP elevation and early hepatic dysfunction by poor parenchymal vascularization in the congestive area. 36 Precise underlying mechanisms of liver failure after extended resection are poorly understood in humans.…”

Section: Discussionmentioning

confidence: 97%

Posthepatectomy Portal Vein Pressure Predicts Liver Failure and Mortality after Major Liver Resection on Noncirrhotic Liver

et al. 2013

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Section: Discussionmentioning

confidence: 97%

Posthepatectomy Portal Vein Pressure Predicts Liver Failure and Mortality after Major Liver Resection on Noncirrhotic Liver

et al. 2013

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“…Following living donor liver transplantation using the left liver graft, outflow obstruction occurs in the donor remnant liver and reportedly causes impairment of regeneration and postoperative hepatic parameters . However, the effects of the LV Out‐Ob on short‐term outcomes and regeneration remain unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Following such a procedure, outflow obstruction occurs in the donor remnant liver and can cause portal vein regurgitation or the development of intersegmental venous communication . Our group previously reported impaired regeneration in the right paramedian sector and elevated alanine aminotransferase (ALT) levels in donors who underwent left liver procurement including the MHV. However, liver volume of hepatic vein (HV) or portal vein territory was not accurately assessed because volumetric analysis using 3‐dimensional computed tomography (CT) was unavailable during the early 2000s.…”

mentioning

confidence: 99%

Influence of outflow‐obstructed liver volume and venous communication development: A three‐dimensional volume study in living donors

Kawaguchi¹,

Hasegawa²,

Okura

et al. 2017

Liver Transpl

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Living donor liver transplantation using the left liver graft with the middle hepatic vein (MHV) is a well-established procedure. Following such procedures, outflow obstruction occurs in remnant livers. However, the effects of the outflow-obstructed liver volume (LV ), with or without venous communication development, remain unclear. The aim of the study is to investigate effects of outflow-obstructed regions by focusing on short-term outcomes and remnant liver hypertrophy in left liver procurement donors. Of 532 donors, we collected data from 119 undergoing left liver procurement with the MHV. Postoperative hepatic parameters, venous communication development, and liver hypertrophy were evaluated in 2 donor groups based on LV . The left liver was procured with the MHV in 119 donors, who formed 2 more groups based on the median LV : large-outflow-obstruction group (n = 60; LV ≥ 263 mL) and small-outflow-obstruction (n = 59; LV < 263 mL) group. Postoperative liver function parameters were significantly impaired in the large-outflow-obstruction group compared with the small-outflow-obstruction group. Postoperative venous communication developed in 52 (66.7%) of 78 donors analyzed. Hypertrophy ratios in remnant right livers and right paramedian sectors were significantly higher in the small-outflow-obstruction group than in the large-outflow-obstruction group (P = 0.01 and P = 0.02, respectively). The liver hypertrophy ratio of outflow-obstructed regions was better, especially in small regions developing venous communication (P = 0.001). The postoperative morbidity rate did not differ significantly (P = 0.66). In conclusion, the procurement of the left liver graft with the MHV was safely performed with minimal morbidity by assessing the donor remnant right liver volume with and without outflow obstruction. Attention should be paid that postoperative hepatic parameters and remnant liver hypertrophy were impaired in the remnant livers with large outflow-obstructed regions compared with those with small outflow-obstructed regions. Liver Transplantation 23 1531-1540 2017 AASLD.

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“…Tanaka et al [18] reported excellent short-and long-term results in 11 patients who underwent right hemihepatectomy with preservation of the ventral right anterior section guided by hepatic venous drainage. Kaneko et al [19] found that the congested volume of the MHV drainage area was associated with high alanine aminotransferase levels after left liver harvesting with the MHV. Kido et al [20] also showed the importance of hepatic drainage in liver regeneration.…”

Section: Discussionmentioning

confidence: 99%

Total resection of the right hepatic vein drainage area with the aid of three-dimensional computed tomography

et al. 2011

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Relation Between the Middle Hepatic Vein Drainage Area Volume and Alanine Aminotransferease After Left Liver Harvesting

Cited by 5 publications

References 6 publications

Posthepatectomy Portal Vein Pressure Predicts Liver Failure and Mortality after Major Liver Resection on Noncirrhotic Liver

Posthepatectomy Portal Vein Pressure Predicts Liver Failure and Mortality after Major Liver Resection on Noncirrhotic Liver

Influence of outflow‐obstructed liver volume and venous communication development: A three‐dimensional volume study in living donors

Total resection of the right hepatic vein drainage area with the aid of three-dimensional computed tomography

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