Relation Between the Incidence and Level of Pigment Cell Antibodies and Disease Activity in Vitiligo

Harning, Ronald; Cui, Jian; Bystryn, Jean‐Claude

doi:10.1111/1523-1747.ep12492607

Cited by 167 publications

(108 citation statements)

References 13 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…12,13 Two principal hypotheses concerning the etiology of vitiligo include: (1) the self-destruct model, which suggests that biochemical and/or structural defects inherent to patient melanocytes contribute to the initiation and/or progression of melanocyte cytolysis; and (2) the autoimmune model, which suggests that melanocyte death occurs through inappropriate immune system destruction of pigment cells. 11,14 There is considerable evidence that disease progression in some vitiligo patients involves autoimmune attack of the melanocytes, as evidenced by the presence of both cellular [15][16][17] and humoral [18][19][20] antimelanocyte autoimmune responses.…”

Section: Introductionmentioning

confidence: 99%

Genes of the LMP/TAP cluster are associated with the human autoimmune disease vitiligo

She

McCormack

2003

Genes Immun

View full text Add to dashboard Cite

Genes within the class II region of the major histocompatibility complex (MHC), including genes involved in antigen processing and presentation, have been reported to be associated with several autoimmune diseases. We report here that the LMP/TAP gene region is significantly associated with vitiligo, a disorder in which biochemical defects and/or autoimmune destruction cause melanocyte loss and resulting skin depigmentation. Case/control analyses revealed genetic association of vitiligo in Caucasian patients with an early age of onset with the transporter associated with antigen processing-1 (TAP1) gene. A familybased association method revealed biased transmission of specific alleles from heterozygous parents to affected offspring for the TAP1 gene, as well as for the closely linked LMP2 and LMP7 genes encoding subunits of the immunoproteasome. No association with vitiligo was found for the MECL1 gene, which encodes a third immunoproteasome subunit and is unlinked to the MHC class II region. These results suggest a possible role for the MHC class I antigen processing and/or presentation pathway in the antimelanocyte autoimmune response involved in vitiligo pathogenesis.

show abstract

Section: Introductionmentioning

confidence: 99%

Genes of the LMP/TAP cluster are associated with the human autoimmune disease vitiligo

She

McCormack

2003

Genes Immun

View full text Add to dashboard Cite

show abstract

“…This hypothesis was based on the observation that several autoimmune diseases are associated with vitiligo. Additionally, increased autoantibody titers against melanocytic antigens have been reported (Harning et al, 1991) and elevated serum levels of soluble interleukin (IL)-2-receptor that correlate with disease activity have also been reported (Honda et al, 1997). The latter parameter, observed in various infectious and autoimmune diseases, is particularly related to the activation of immunocompetent cells (Keystone et al, 1988;Wolf and Brelsford, 1988).…”

mentioning

confidence: 99%

Local Immune Response in Skin of Generalized Vitiligo Patients

Wijngaard

Wańkowicz-Kalińska

Poole

et al. 2000

Laboratory Investigation

219

View full text Add to dashboard Cite

SUMMARY:In situ immune infiltrates in lesional, perilesional, and nonlesional skin biopsies from patients with vitiligo were analyzed by immunohistochemistry and compared with immune infiltrates found in the skin of normal healthy donors and relevant disease controls. An increased influx of activated skin-homing T cells and macrophages were seen in the perilesional biopsies. The overall percentages of cutaneous leukocyte-associated antigen-positive (CLA ϩ ) T cells were similar to those found in normal healthy donors. This is compatible with the similar expression of E-selectin. Most strikingly, however, the CLA ϩ T cells in perilesional skin were mainly clustered in the vicinity of disappearing melanocytes, and 60% to 66% of these interacting T cells expressed perforin and granzyme-B. The perforin ϩ /granzyme-B ϩ cells were not seen in locations different from that of disappearing melanocytes. Interestingly, the majority of the infiltrating T cells were HLA-DR/CD8 ϩ . Another hallmark of the present study is the focal expression of intercellular adhesion molecule (ICAM)-1 and HLA-DR in the epidermis at the site of interaction between the immune infiltrates and the disappearing melanocytes. The data presented in this study are consistent with a major role for skin-homing T cells in the death of melanocytes seen in vitiligo. (Lab Invest 2000, 80:1299-1309.

show abstract

“…11 In another study, the serum of patients with vitiligo showed a higher complement-mediated cytolytic activity against human melanocytes when compared to control serum. 12 Melanocytes around the lesions express more MHCII as well as intercellular adhesion molecule than do melanocytes located in other areas.…”

Section: Immunological Aspects Antimelanocyte Antibodiesmentioning

confidence: 95%

Estudo comparativo entre vitiligo, nevo halo e lúpus eritematoso vitiligóide por meio de métodos imunológicos, histológicos e imuno-histoquímicos

Filho

Rivitti

Miyauchi

et al. 2005

An. Bras. Dermatol.

View full text Add to dashboard Cite

The results confirm the existence of antimelanocyte antibodies in vitiligo and halo nevus. It is not possible to rule out some immunological phenomena similar to those occurring in vitiligo and halo nevus in the genesis of vitiligoid lesions in lupus erythematous. The detection of melanocytes in achromic lesions of vitiligo suggests the predominance of a functional inhibitory mechanism rather than cell destruction in the genesis of the disease. Keywords: Allergy and Immunology; Lupus; Nevus, Pigmented; Vitiligo. Resumo: FUNDAMENTOS: O estudo compara o vitiligo, o nevo halo (NH) e lúpus eritematoso vitiligóide (LEV) do ponto de vista imunológico, histológico e histoquímico. OBJETIVOS: Avaliar diferenças imuno-histoquímicas entre essas doenças e investigar se a despigmentação do LEV deve-se à destruição pós-infla-

show abstract

Relation Between the Incidence and Level of Pigment Cell Antibodies and Disease Activity in Vitiligo

Cited by 167 publications

References 13 publications

Genes of the LMP/TAP cluster are associated with the human autoimmune disease vitiligo

Genes of the LMP/TAP cluster are associated with the human autoimmune disease vitiligo

Local Immune Response in Skin of Generalized Vitiligo Patients

Estudo comparativo entre vitiligo, nevo halo e lúpus eritematoso vitiligóide por meio de métodos imunológicos, histológicos e imuno-histoquímicos

Contact Info

Product

Resources

About