Relation between the expression levels of the POU transcription factors Skn-1a and Skn-1n and keratinocyte differentiation

Takemoto, Hironobu; Tamai, Katsuto; Akasaka, Eijiro; Rokunohe, Daiki; Takiyoshi, Noriko; Umegaki, Noriko; Nakajima, Koji; Aizu, Takayuki; Kaneko, Takahide; Nakano, Hajime; Sawamura, Daisuke

doi:10.1016/j.jdermsci.2010.10.006

Cited by 18 publications

(12 citation statements)

References 10 publications

(7 reference statements)

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“…This variant contains two functional domains: a primary C-terminal transactivation domain and a combined N-terminal inhibitory domain and transactivation domain (99). Because of the combined effects of the N-termini, it is not surprising that Oct11 isoforms have different functions in keratinocyte proliferation and differentiation (97, 100). Oct11 has also recently been shown to play a critical role in specifying taste receptor cell lineage (101) and is a candidate cervical cancer suppressor protein (see Section 7).…”

Section: Oct Members and Their Tissue Expression Genomic Organizamentioning

confidence: 99%

Octamer-binding transcription factors: genomics and functions

Zhao¹

2013

Front Biosci

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The Octamer-binding proteins (Oct) are a group of highly conserved transcription factors that specifically bind to the octamer motif (ATGCAAAT) and closely related sequences that are found in promoters and enhancers of a wide variety of both ubiquitously expressed and cell type-specific genes. Oct factors belong to the larger family of POU domain factors that are characterized by the presence of a highly conserved bipartite DNA binding domain, consisting of an amino-terminal specific subdomain (POUS) and a carboxyl-terminal homeo-subdomain (POUH). Eleven Oct proteins have been named (Oct1-11), and currently, eight genes encoding Oct proteins (Oct1, Oct2, Oct3/4, Oct6, Oct7, Oct8, Oct9, and Oct11) have been cloned and characterized. Oct1 and Oct2 are widely expressed in adult tissues, while other Oct proteins are much more restricted in their expression patterns. Oct proteins are implicated in crucial and versatile biological events, such as embryogenesis, neurogenesis, immunity, and body glucose and amino acid metabolism. The aberrant expression and null function of Oct proteins have also been linked to various diseases, including deafness, diabetes and cancer. In this review, I will report both the genomic structure and major functions of individual Oct proteins in physiological and pathological processes.

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Section: Oct Members and Their Tissue Expression Genomic Organizamentioning

confidence: 99%

Octamer-binding transcription factors: genomics and functions

Zhao¹

2013

Front Biosci

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“…In fact, many results concerning differentiation abnormalities including increase of K6 and K16 expression, and decrease of profilaggrin expression were found in psoriatic epidermis [6][7][8][9]. We usually recognize tick scale in psoriasis lesions and found hyperkeratosis and parakeratosis are found histologically.…”

mentioning

confidence: 97%

“…Activated keratinocytes secrete high levels of TGF-b1, which is believed to be responsible for myofibroblast differentiation [5][6][7]. Activated keratinocytes secrete high levels of TGF-b1, which is believed to be responsible for myofibroblast differentiation [5][6][7].…”

mentioning

confidence: 99%

Spectroscopic evidence of abnormal structure of psoriasis vulgaris stratum corneum

Nakagawa

Minakawa

Sawamura

2012

Journal of Dermatological Science

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“…Conversely, another adaptive haplotype at POU2F3 shows a frequency of~66% in East Asians and less than 1% in Europeans (Vernot and Akey, 2014). This gene is a homeobox transcription factor regulating keratinocyte proliferation and differentiation, and is primarily expressed in the epidermis (Cabral et al, 2003;Takemoto et al, 2010). More strikingly, some of the HLA class I alleles of the human Major Histocompatibility Complex, such as the HLA-B*73 allele, segregating in modern western Asian populations, might have been acquired from Denisovans (Abi-Rached et al, 2011).…”

Section: Population Admixture: Denisovansmentioning

confidence: 99%