Relation between symptoms of insomnia, depression, sleep quality, anti-tumor necrosis factor therapy and disrupted circadian clock genes’ expression in inflammatory bowel disease

Sochal, Marcin; Binienda, Agata; Ditmer, Marta; Małecka-Wojciesko, Ewa; Białasiewicz, Piotr; Fichna, Jakub; Talar-Wojnarowska, Renata; Gabryelska, Agata

doi:10.20452/pamw.16487

Cited by 2 publications

(1 citation statement)

References 34 publications

(47 reference statements)

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“…Insomnia also frequently accompanies psychiatric disorders and immunomediated diseases. [8][9][10] The causes of insomnia remain elusive. Insomnia might have genetic predisposing factors, as familial aggregation has been observed.…”

Section: Introductionmentioning

confidence: 99%

Investigating the Role of BDNF in Insomnia: Current Insights

Ditmer,

Gabryelska,

Turkiewicz

et al. 2023

NSS

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Insomnia is a common disorder defined as frequent and persistent difficulty initiating, maintaining, or going back to sleep. A hallmark symptom of this condition is a sense of nonrestorative sleep. It is frequently associated with other psychiatric disorders, such as depression, as well as somatic ones, including immunomediated diseases. BDNF is a neurotrophin primarily responsible for synaptic plasticity and proper functioning of neurons. Due to its role in the central nervous system, it might be connected to insomnia of multiple levels, from predisposing traits (neuroticism, genetic/epigenetic factors, etc.) through its influence on different modes of neurotransmission (histaminergic and GABAergic in particular), maintenance of circadian rhythm, and sleep architecture, and changes occurring in the course of mood disturbances, substance abuse, or dementia. Extensive and interdisciplinary evaluation of the role of BDNF could aid in charting new areas for research and further elucidate the molecular background of sleep disorder. In this review, we summarize knowledge on the role of BDNF in insomnia with a focus on currently relevant studies and discuss their implications for future projects.

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Section: Introductionmentioning

confidence: 99%

Investigating the Role of BDNF in Insomnia: Current Insights

Ditmer,

Gabryelska,

Turkiewicz

et al. 2023

NSS

Self Cite

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Identification of key genes as potential diagnostic and therapeutic targets for comorbidity of myasthenia gravis and COVID-19

Huang,

Zuo,

Yang

et al. 2024

Front. Neurol.

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IntroductionMyasthenia gravis (MG) is a chronic autoimmune neuromuscular disorder. Coronavirus disease 2019 (COVID-19) has a significant impact on the health and quality of life of MG patients and may even trigger the onset of MG in some cases. With the worldwide development of the COVID-19 vaccination, several new-onset MG cases and exacerbations following the COVID-19 vaccines have been acknowledged. The potential link between myasthenia gravis (MG) and COVID-19 has prompted the need for further investigation into the underlying molecular mechanism.Methods and resultsThe differential expression analysis identified six differentially expressed genes (DEGs) shared by myasthenia gravis (MG) and COVID-19, namely SAMD9, PLEK, GZMB, JUNB, NR4A1, and NR1D1. The relationship between the six common genes and immune cells was investigated in the COVID-19 dataset. The predictive value of the shared genes was assessed and a nomogram was constructed using machine learning algorithms. The regulatory miRNAs, transcription factors and small molecular drugs were predicted, and the molecular docking was carried out by AutoDock.DiscussionWe have identified six common DEGs of MG and COVID-19 and explored their immunological effects and regulatory mechanisms. The result may provide new insights for further mechanism research.

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Relation between symptoms of insomnia, depression, sleep quality, anti-tumor necrosis factor therapy and disrupted circadian clock genes’ expression in inflammatory bowel disease

Cited by 2 publications

References 34 publications

Investigating the Role of BDNF in Insomnia: Current Insights

Investigating the Role of BDNF in Insomnia: Current Insights

Identification of key genes as potential diagnostic and therapeutic targets for comorbidity of myasthenia gravis and COVID-19

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