Relation between severity of left-ventricular hypertrophy and prognosis in patients with hypertrophic cardiomyopathy

Elliott, Perry; Gimeno-Blanes, Juan Ramón; Mahon, Niall; Poloniecki, Jan; McKenna, William J.

doi:10.1016/s0140-6736(00)04005-8

Cited by 432 publications

(319 citation statements)

References 24 publications

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“…[1][2][3][4][5][6][7]19,21,22 The importance of septal thickness as a predictor of SCD remains contentious. Spirito et al 5 reported no incidence of SCD in 400 patients with septal thickness Ͻ15 mm compared with a 2% annual risk in patients with a septal thickness Ͼ30 mm.…”

Section: Discussionmentioning

confidence: 99%

“…Mortality was influenced by the presence of several other clinical markers. 6 Two pediatric reports have studied adverse clinical outcomes in children Ͼ1 year of age. In a study of 99 children, Yetman et al 22 …”

Section: Discussionmentioning

confidence: 99%

“…The greatest LV wall thickness was measured in each of these quadrants in diastole and systole at the level of the mitral valve papillary muscles. 6 Maximal LV wall thickness was defined as the greatest thickness in any of these segments. The peak LV outflow tract gradient was determined from the modified Bernoulli equation.…”

Section: Echocardiographic Analysismentioning

confidence: 99%

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Characterization of Left Ventricular Diastolic Function by Tissue Doppler Imaging and Clinical Status in Children With Hypertrophic Cardiomyopathy

et al. 2004

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Characterization of Left Ventricular Diastolic Function by Tissue Doppler Imaging and Clinical Status in Children With Hypertrophic Cardiomyopathy

et al. 2004

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“…Elliot et al [5] reported that from 630 HCM patients, SCD occurred in 39 cases and 10 of them had LV hypertrophy > 30 mm. The patients with LV hypertrophy over 30 mm had higher risk of the SCD (p = 0.049).…”

Section: Discussionmentioning

confidence: 99%

Kardiomiopatia przerostowa u bezobjawowej 24-letniej kobiety w ciąży — postępowanie według wytycznych ESC

et al. 2018

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We present a case of 24-year-old asymptomatic pregnant woman in 18 hbd with hypertrophic cardiomyopathy (HCM). An echocardiogram revealed the hypertrophy of all walls of the left ventricle (LV), except for the posterolateral wall, from 21 mm to 31 mm and septal hypertrophy up to 36 mm. During the first 48-h electrocardiogram (ECG) monitoring, five episodes of slow ventricular tachycardia (VT) consisted of three ExV up to 108/min were recorded. The 5-year HCM sudden cardiac death (SCD) risk score revealed the low risk of 2.25% -implantable cardioverter-defibrillator (ICD) not indicated. After a C-section delivery in 37 hbd, the control echocardiography revealed the enlargement of the LV wall hypertrophy up to 38 mm. In the 48-h ECG monitoring, two episodes of asymptomatic non-sustained VT consisted of four and seven ExV up to 162/min were registered. The 5-year HCM SCD risk came up to the intermediate level of 5.91% (ICD may be considered, class IIb B of recommendations). Based on the clinical and echocardiographic findings with dynamic progress in the LV hypertrophy, exacerbation of ventricular arrhythmias and increase of N-terminal natriuretic propeptide type B, the ICD was implanted. As presented by Maron & Maron at the European Society of Cardiology Congress in London 2015, magnetic resonance scanning with the late gadolinium enhancement (LGE) estimation may be helpful in making the decision on the ICD implantation, especially within the group of intermediate 5-year risk of SCD (4-6%) with massive LV hypertrophy. The Authors suggest the extensive LGE (≥ 15%) as a primary SCD risk factor as well as a potential risk factor when conventional evaluation of the ICD implantation indications is ambiguous.

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“…Predicting risk is a key component of the management of HCM: wall thickness, LVOTO gradient and left atrium dimension are part of the factors for the risk stratification of HCM patients (86). It is well established that the severity and extent of LVH measured by echocardiography are associated with the risk of SCD: a maximum wall thickness of R30 mm has a greater risk of SCD (87,88,89). The size of the left atrium is often enlarged and provides important prognostic information (86,90).…”

Section: Managementmentioning

confidence: 99%

Diagnosis and Management of Hypertrophic Cardiomyopathy

Maron¹

2004

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The clinical spectrum of hypertrophic cardiomyopathy (HCM) is complex and includes a variety of phenotypes, which leads to different types of manifestations. Although most of the patients are asymptomatic, a significant proportion of them will develop symptoms or risk of arrhythmias and sudden cardiac death (SCD). Therefore, the objectives of HCM diagnosis and management are to relieve the patients' symptoms (chest pain, heart failure, syncope, palpitations, etc.), prevent disease progression and major cardiovascular complications and SCD. The heterogeneity of HCM patterns, their symptoms and assessment is a challenge for the cardiologist.

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Relation between severity of left-ventricular hypertrophy and prognosis in patients with hypertrophic cardiomyopathy

Cited by 432 publications

References 24 publications

Characterization of Left Ventricular Diastolic Function by Tissue Doppler Imaging and Clinical Status in Children With Hypertrophic Cardiomyopathy

Characterization of Left Ventricular Diastolic Function by Tissue Doppler Imaging and Clinical Status in Children With Hypertrophic Cardiomyopathy

Kardiomiopatia przerostowa u bezobjawowej 24-letniej kobiety w ciąży — postępowanie według wytycznych ESC

Diagnosis and Management of Hypertrophic Cardiomyopathy

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