Relation between serum cotinine levels and trophic lesions in patients with critical limb ischemia: a pilot study

Ciocan, Răzvan A; Cătană, Cristina-Sorina; Drugan, Cristina; Gherman, Claudia; Ciocan, Andra; Drugan, Tudor; Bolboacă, Sorana D.

doi:10.1080/17843286.2019.1577530

Cited by 1 publication

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, circulating values of chitotriosidase and neopterin proved similar in smokers and non-smokers regardless of the group (CRC or C group). As previously reported, smoking is not a confounder [ 21 , 22 ]. In neoplastic patients, the inflammation effect induced by exposure to nicotine could be masked by tumor-associated chronic inflammation.…”

Section: Discussionmentioning

confidence: 58%

“…The enzyme is closely related to macrophage and neutrophilic activation. Chitotriosidase serum levels had higher values in patients with critical limb ischemia [ 21 ], diabetes mellitus [ 22 ], lysosomal storage disorders [ 23 ], overweight and obesity in children [ 24 ], breast or prostate cancer [ 20 ], and pulmonary diseases [ 25 , 26 ]. Patients with CRC had higher levels of chitinase (median = 21.13 ng/μL, IQR = (17.35–26.16)) than healthy controls (median = 17.21 ng/μL, IQR = (15.39–21.27); p < 0.0001) [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Exploratory Evaluation of Neopterin and Chitotriosidase as Potential Circulating Biomarkers for Colorectal Cancer

Ciocan

Hajjar

et al. 2023

Biomedicines

View full text Add to dashboard Cite

Chronic inflammation is demonstrated to play a direct role in carcinogenesis. Our exploratory study aimed to assess the potential added value of two inflammation biomarkers, chitotriosidase and neopterin, in follow-up evaluation of patients with colorectal cancer (CRC). An observational exploratory study was conducted. Patients with CRC and matched controls (1:1, age, sex, and living environment) were evaluated. The patients with CRC (CRC group) and controls were assessed at baseline (before surgical intervention for patients with CRC). Patients with CRC were also evaluated at 1-year follow-up. Significantly more patients with blood group A (54.5% vs. 25.0%) and smokers (50.0% vs. 22.7%) were in the CRC group. The serum values of chitotriosidase and neopterin were higher in CRC patients than in controls, but only neopterin reached the conventional level of statistical significance (p-value = 0.015). The circulating chitotriosidase and neopterin values decreased significantly at 1-year follow-up (p-value < 0.0001). Patients with higher N- and M-stage showed statistically significant higher levels of chitotriosidase and neopterin at baseline and 1-year follow-up (p-values < 0.03). Circulating chitotriosidase levels also showed statistically significant differences regarding baseline and 1-year follow-up on patients with CRC and different differentiation grades (p-values < 0.02). The circulating levels of neopterin significantly decreased at 1-year follow-up, indicating its potential as a prognostic marker. The circulating values of chitotriosidase and neopterin exhibit significant differences in patients with than without recurrences. Our results support further evaluation of chitotriosidase and neopterin as prognostic markers in patients with CRC.

show abstract

Section: Discussionmentioning

confidence: 58%