Relation Between Red Blood Cell Distribution Width and Venous Thrombosis

Golcuk, Yalcin; Golcuk, Burcu; Elbi, Hüseyin

doi:10.1016/j.amjcard.2016.01.010

Cited by 2 publications

(4 citation statements)

References 10 publications

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“…In the proposed meta-analysis, we will therefore explore the prognostic utility of RDW in acute PE patients. Prior studies have reported a significant relationship between RDW and acute PE incidence, but these findings remain controversial [13] …”

Section: Discussionmentioning

confidence: 96%

“…Prior studies have reported a significant relationship between RDW and acute PE incidence, but these findings remain controversial. [ 13 ]…”

Section: Discussionmentioning

confidence: 99%

“…Prior studies have reported a significant relationship between RDW and acute PE incidence, but these findings remain controversial. [13] To establish the relative utility of RDW as a means of predicting PE-related mortality, we will conduct the metaanalysis and systematic review outlined in the present study protocol. The results of our study will be reported in strict compliance with PRISMA criteria, and will add to the current literature by providing compelling evidence with the potential to improve care management for patients in need.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic value of red blood cell distribution width in patients with acute pulmonary embolism

2021

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Background: Prior reports have suggested that the red blood cell distribution width (RDW) parameter could be measured as a prognostic indicator in pulmonary embolism (PE) patients, thereby helping to guide their care. However, no systematic analyses on this topic have been completed to date, and the exact relationship between RDW and PE remains to be fully clarified. We will therefore conduct a systematic literature review with the goal of defining the correlation between RDW and mortality in acute PE cases. Methods: The EMBASE, Web of Knowledge, PubMed, ClinicalTrials.gov, and Cochrane Library databases will be searched for all relevant studies published from inception through March 2021 using the following search strategy: (“red blood cell distribution width”) AND (“pulmonary embolism”). Two authors will independently identify eligible studies and extract data. The Q and I 2 statistics will be used to judge heterogeneity among studies. Results: This study will establish the relative efficacy of RDW as a metric for predicting PE patient mortality. Conclusions: This study will offer a reliable, evidence-based foundation for the clinical utilization of RDW as a tool for gauging mortality risk in acute PE patients. Ethics and dissemination: As this is a protocol for a systematic review of previously published data, no ethical approval is required. Electronic dissemination of study results will be done through a peer-review publication or represented at a related conference.

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Section: Discussionmentioning

confidence: 96%

“…Prior studies have reported a significant relationship between RDW and acute PE incidence, but these findings remain controversial. [ 13 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prognostic value of red blood cell distribution width in patients with acute pulmonary embolism

2021

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“… 40 Chronic inflammation in our patients led to anemia (a decrease in RBC and Hb), which promoted an increase in EPO. Increased RDW levels were found to be a powerful stimulation of erythropoiesis by EPO, according to Golcuk Y et al 41 EPO increased significantly with increasing RDW levels. 42 There is a specific relationship between inflammatory cytokines and RDW.…”

Section: Discussionmentioning

confidence: 97%

Association Between Red Blood Cell Indices and Preoperative Deep Vein Thrombosis in Patients Undergoing Total Joint Arthroplasty: A Retrospective Study

Xiong

et al. 2022

Clin Appl Thromb Hemost

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Purpose To investigate the association of red blood cell (RBC), hemoglobin (Hb), red cell distribution width-coefficient of variation (RDW-CV), and red cell distribution width-standard deviation (RDW-SD) with preoperative deep vein thrombosis (DVT) in patients undergoing total joint arthroplasty (TJA). Methods A total of 2059 TJA patients were enrolled. We used the ratios of RBC, Hb, RDW-CV, and RDW-SD to DVT before TJA to create the receiver operator characteristic (ROC) curve, thereby calculating the cut-off values and the area under the curve (AUC). The patients were categorized into groups based on cut-off value, and risk factors for DVT before TJA were subsequently analyzed. We included the variates that were statistically significant in the univariate analysis in the multivariate binary logistic regression analysis. Results Preoperative DVT occurred in 107 cases (5.20%). Based on the ROC curve, we found that the AUC for RBC, Hb, RDW-CV, and RDW-SD were 0.658, 0.646, 0.568, and 0.586, respectively. Multivariate binary regression analysis revealed that the risk of preoperative DVT in TJA patients with RBC≤3.92*109 /L, Hb≤118g/L, RDW-CV≥13.2%, and RDW-SD≥44.6fL increased 3.02 ( P < 0.001, 95% confidence interval (CI) [2.0–4.54]), 2.15 ( P < 0.001, 95% CI [1.42–3.24]), 1.54 ( P = 0.038, 95% CI [1.03–2.3]), and 1.98 times ( P = 0.001, 95% CI [1.32–2.98]), respectively. The risk of preoperative DVT in patients with corticosteroid use increased approximately 2.6 times ( P = 0.002, 95% CI [1.22–5.81]). Conclusion We found that decreased RBC and Hb, increased RDW-CV and RDW-SD, and corticosteroid use were independent risk factors for preoperative DVT in patients undergoing TJA.

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Relation Between Red Blood Cell Distribution Width and Venous Thrombosis

Cited by 2 publications

References 10 publications

Prognostic value of red blood cell distribution width in patients with acute pulmonary embolism

Prognostic value of red blood cell distribution width in patients with acute pulmonary embolism

Association Between Red Blood Cell Indices and Preoperative Deep Vein Thrombosis in Patients Undergoing Total Joint Arthroplasty: A Retrospective Study

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