Relation Between Plasma Tumor Necrosis Factor-α and Insulin Sensitivity in Elderly Men With Non–Insulin-Dependent Diabetes Mellitus

Nilsson, Jan; Jovinge, Stefan; Niemann, Audrey; Reneland, Richard; Lithell, Hans

doi:10.1161/01.atv.18.8.1199

Cited by 183 publications

(121 citation statements)

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“…Studies of obesity, insulin resistance, and type 2 diabetes have shown relationships with proinflammatory cytokines and acute-phase reactants (4,(11)(12)(13). Obesity has been associated with oxidative stress (38).…”

Section: Discussionmentioning

confidence: 99%

“…Prospective studies have reported associations among various markers of inflammation and incidence of diabetes (7)(8)(9)(10), and it has been proposed that inflammation has a causal role for the development of diabetes (4). In particular, inflammatory cytokines formed in the adipose tissue are associated with glucose dysregulation (4,(11)(12)(13). However, the joint effect of overweight and inflammation on the prevalence of diabetes has not been studied extensively in the general population.…”

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confidence: 99%

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Inflammation-Sensitive Plasma Proteins, Diabetes, and Mortality and Incidence of Myocardial Infarction and Stroke

et al. 2003

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This study explores the relationship of inflammationsensitive plasma proteins (ISPs) with the prevalence of diabetes and the interrelationships between ISPs and diabetes in the prediction of death and incidence of myocardial infarction and stroke. Plasma levels of fibrinogen, ␣1-antitrypsin, haptoglobin, ceruloplasmin, and orosomucoid were assessed in 6,050 men, aged 28 -61 years. All-cause and cardiovascular mortality and incidence of myocardial infarction and stroke were monitored over 18.7 ؎ 3.7 years. Prevalence of diabetes (n ‫؍‬ 321) was significantly associated with ISP levels among overweight and obese men but not among men with BMI <25 kg/m 2 . The association was similar for insulin resistance according to homeostasis model assessment. High ISP levels (two or more ISPs in the top quartile) increased the cardiovascular risk among diabetic men. The risk factor-adjusted relative risks for cardiovascular mortality, myocardial infarction, and stroke were 2.8 (CI 1.8 -4.5), 2.2 (1.5-3.2), and 2.5 (1.4 -4.6), respectively, for diabetic men with high ISP levels (reference: nondiabetic men with low ISP levels). The corresponding risks for diabetic men with low ISP levels were 1.8 (1.1-3.0), 1.3 (0.8 -2.1), and 1.2 (0.6 -2.5), respectively. In conclusion, in this populationbased cohort, diabetes was associated with increased ISP levels among overweight and obese men but not among men with normal weight. High ISP levels increased the cardiovascular risk similarly in diabetic as compared with nondiabetic men. Diabetes 52:442-447, 2003 D iabetes and impaired glucose tolerance have been associated with increased plasma concentrations of various inflammation-sensitive plasma proteins (ISPs), including fibrinogen, haptoglobin, ␣1-antitrypsin, serum amyloid A, C-reactive protein, and orosomucoid (1-6). Prospective studies have reported associations among various markers of inflammation and incidence of diabetes (7-10), and it has been proposed that inflammation has a causal role for the development of diabetes (4). In particular, inflammatory cytokines formed in the adipose tissue are associated with glucose dysregulation (4,11-13). However, the joint effect of overweight and inflammation on the prevalence of diabetes has not been studied extensively in the general population. Whether prevalence of diabetes shows similar relationships with ISPs in lean and obese subjects is largely unknown.Many prospective studies have reported relationships between moderately increased plasma concentrations of ISPs and increased incidences of myocardial infarction and stroke (14 -17). It is now widely accepted that inflammation has a role in the development of atherosclerosis. Diabetes is another risk factor for myocardial infarction and stroke (18 -20). The relationships between diabetes and other traditional cardiovascular risk factors, e.g., an adverse lipid profile, obesity, hypertension, and physical inactivity, cannot completely explain the increased risk in diabetic individuals (18). Even though it has been suggested that infla...

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Inflammation-Sensitive Plasma Proteins, Diabetes, and Mortality and Incidence of Myocardial Infarction and Stroke

et al. 2003

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“…6 Yapılan daha önceki çalışmalarda IL-6, TNFα, CRP gibi inflamasyon belirteçlerinin diyabetle ilişkili olduğu söylenmiştir. 7,8 TNF α'nın insülin sinyal yolakları ve β hücre fonksiyonlarını etkilediği ve bu durumun lökosit sayımı ve diyabetle ilişkili olduğu bildirilmiştir.…”

Section: Discussionunclassified

Leukocyte Count as Chronic Inflammation Markers in Type 2 Diabetes Patients

Durmuş¹,

Aypak²,

Görpelioğlu³

2017

Ankara Medical Journal

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ÖzAmaç: Epidemiyolojik araştırmalar periferik kandaki lökosit sayısı ile Tip 2 Diyabetes Mellitus (T2DM) arasında ilişki bulunduğunu göstermesine rağmen bu ilişki sistematik olarak incelenmemiştir. Bu çalışmada, T2DM tanısı olan hastaların (T2DM(+)) lökosit sayımı ve biyokimya tetkik sonuçlarının diyabeti olmayan hastaların (T2DM(-)) sonuçlarıyla karşılaştırılması amaçlanmıştır. Materyal ve Metot: Çalışmaya; 02.02.2015-30.09.2015 tarihleri arasında Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi Aile Hekimliği Poliklinikleri'ne başvuran hastalar alınmıştır. Hastaların antropometrik ölçümleri, tam kan sayımı ve biyokimyasal testlerinin sonuçları kaydedilmiştir ve bu değerler T2DM(+) ile T2DM(-) grupları arasında karşılaştırılmıştır. Bulgular: Çalışmaya dâhil edilen 286 hastanın yaş ortalaması 58,7±10,5 yıl olarak saptandı. T2DM(+) (n=108) ve T2DM(-) (n=178) gruplarının yaş ve cinsiyet dağılımları arasında fark yoktu. T2DM(+) grubun ortalama lökosit sayısının T2DM(-) grubundan yüksek olduğu saptandı (7,73 × 103/ml; 7,17 × 103/ml; p=0,001). T2DM(+) grubun bel çevresi, vücut kitle indeksi (VKİ), açlık kan şekeri (AKŞ), alanin aminotransferaz (ALT) ve trigliserid değerleri T2DM(-) grubuna göre anlamlı olarak yüksek olduğu, düşük yoğunluklu kolesterol (LDL) ve yüksek yoğunluklu kolesterol (HDL) değerlerinin ise anlamlı olarak daha düşük olduğu bulundu. Sonuç: Lökosit sayısı normal sınırlar içerisinde dahi T2DM hastalarında diyabeti olmayan bireylerden daha yüksektir. Bizim sonuçlarımız kronik inflamasyonun Tip 2 diyabetteki rolünü desteklemektedir. İnflamasyonun diyabetteki rolünü açıklayacak daha kapsamlı çalışmalara ihtiyaç vardır. Anahtar kelimeler: İnflamasyon, diyabet, lökosit sayımı Abstract Objectives: Epidemiological studies have revealed an association between higher total peripheral white blood cells (WBC) count and Type 2 Diabetes Mellitus (T2DM). However, the association has not been systematically investigated. The aim of this study was to compare peripheral leukocyte count and biochemical test results in diabetic and non-diabetic patients. Materials and Methods: The study was conducted among the patients had been followed by Family Medicine Outpatient Clinics of Dışkapı Yıldırım Beyazıt Training and Research Hospital between 02.02.2015-30.09.2015. Patients anthropometric measurements, complete blood cell count and biochemical tests' results were recorded and these values were compared between two groups (T2DM(+) and T2DM(-)). Results: A total of 286 patients (mean age: 58.7±10.5 years) were enrolled. There were no differences in age and sex distribution between T2DM(+) (n=108) and T2DM (-) (n=178) groups. In T2DM(+) group, leukocyte count was found to be higher than T2DM(-) group (7.73 × 103/ml; 7.17 × 103/ml; p=0.001). Waist circumference, body mass index, fasting blood glucose, alanine amino transferase and triglycerides levels were also found to significantly higher in T2DM(+) group. Conversly, high density lipoprotein and low-density lipoprotein levels were found to be significantly lower in T...

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“…Whole body glucose disposal also correlates with TNF levels (111). Elderly men with insulin resistant DM have elevated levels of serum TNF in comparison to healthy elderly men (112). Serum levels of TNF also correlated with BMI, fasting glucose levels, and serum triglyceride levels and inversely with HDL cholesterol levels.…”

Section: Insulin Resistance and Longevity: Beyond Glucosementioning

confidence: 99%

Endocrine and metabolic changes in human aging

Banks

Morley

2000

AGE

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"Aging and death are inevitable. We have no desire to prolong life, if such prolongation entails only added days and years of misery and suffering. On the other hand, for the first time in history, man has within his grasp potent medications of many kinds, among the more important of which are specific hormones capable of retarding if not stopping some of the undesirable features of growing old". Thomas Hodge McGavack Geriatrics 18:181-191 (1963) ABSTRACT Numerous alterations in hormonal secretion occur with aging. In general, these tend towards a disintegration of the normal cyclic secretory patterns resulting in lower total circulating levels. In addition, declines in receptors and postreceptor function further decreases the ability of the hormonal orchestra to maintain coordinated function throughout the organism. Clues to some of these agerelated changes in humans may come from the study of simpler organisms where regulatory systems are known to modulate the aging process. In particular, the interactions among the environment, hormones, and insulin receptor genes have led to new insights into the genetic control of longevity and the development of syndrome X.It is now well established, as summarized in Table 1, that the levels of many hormones are altered with aging (1). Some hormonal levels decrease, reflecting endocrine gland failure, whereas others increase, often because of end organ failure due to a decrease in receptors or a failure of postreceptor function. In the last decade, it has become popular to look to hormone replacement therapy as a mechanism to reverse the aging process. It has become popular to consider this the "hormonal fountain of youth". With aging, dysregulation of food intake accompanied by sarcopenia ('wasting of the flesh") occurs (2). A number of hormonal mechanisms are related to the physiological anorexia of aging (3). In particular, recent studies have suggested that alterations in circulating testosterone levels lead in males to increased leptin levels and thus to anorexia (4).Another area of intense interest in understanding the mechanisms of aging in humans has been the alterations that occur in glucose metabolism with aging and the role of age-related glucose end products (AGE) in accelerating the aging process (5). This area has been closely linked with the changes in nutrition that occur with aging, with insulin resistance, and more recently, with the genes that encode for the insulin receptor. It is of interest that the hormonal changes produced by dietary restriction in rodents are similar to the agerelated hormonal changes in humans, as shown in Table 2 (6). This raises the possibility that these hormonal changes are protective, i,e. slow down metabolism and thus slow down the aging process. This creates a "chicken or egg" hypothesis, illustrated in Figure 1, which asks the question: do aging changes occur because of the decline in hormones or do high hormone levels produce aging changes?This review will briefly examine the available data in each of these areas and...

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Relation Between Plasma Tumor Necrosis Factor-α and Insulin Sensitivity in Elderly Men With Non–Insulin-Dependent Diabetes Mellitus

Cited by 183 publications

References 21 publications

Inflammation-Sensitive Plasma Proteins, Diabetes, and Mortality and Incidence of Myocardial Infarction and Stroke

Inflammation-Sensitive Plasma Proteins, Diabetes, and Mortality and Incidence of Myocardial Infarction and Stroke

Leukocyte Count as Chronic Inflammation Markers in Type 2 Diabetes Patients

Endocrine and metabolic changes in human aging

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