Relation between plasma brain-derived neurotrophic factor and nerve growth factor in the male patients with alcohol dependence

Chul, Boung Lee; Choi, Ihn Geun; Kim, Yong Ku; Ham, Byung Joo; Yang, Byung Hwan; Roh, Sungwon; Choi, Joonho; Lee, Jung Hoon; Oh, Dong Yul; Chai, Young Gyu

doi:10.1016/j.alcohol.2009.04.003

Cited by 52 publications

(34 citation statements)

References 25 publications

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“…Several studies have reported alterations of BDNF serum levels in patients suffering from substance-related addictions such as alcohol and opiate dependence [26,27,32]. In the present study, we found increased serum concentrations of BDNF in a sample of male patients with PG in comparison to individually matched healthy male control subjects.…”

Section: Discussionsupporting

confidence: 68%

“…Recently, it has been reported that behavioural stress significantly increased serum levels of BDNF in healthy controls as well as in alcohol-dependent patients [41]. Furthermore, BDNF serum levels were reported to be increased in alcohol-dependent patients within the first 24 h of abstinence [27]. In PG, frequently experienced craving for as well as daily withdrawal of gambling might act as repetitive stress stimuli, thus inducing those stress-preventive and neuroprotective mechanisms.…”

Section: Discussionmentioning

confidence: 99%

“…Together with Angelucci et al [33], our results suggest that a non-substance-related addiction like PG might be associated with neuroendocrinological changes similar to changes observed in substance-related addictions. Several authors have hypothesized that these alterations represent neuroprotective mechanisms to counteract substance-induced neuronal damage [27,37]. However, in PG one could speculate that increased BDNF levels represent a compensatory mechanism to normalize dopaminergic transmission in the VTA and the NAc, since dysfunctions of the reward system have been shown in PG [16], and BDNF is linked to midbrain dopamine release [19].…”

Section: Discussionmentioning

confidence: 99%

“…In alcohol-dependent patients who had abstained from alcohol for at least 30 days, plasma levels of BDNF were found to be decreased in comparison to healthy controls [26]. In contrast, Lee et al [27] reported increased plasma levels of BDNF in alcohol-dependent patients within 24 h of abstinence.…”

Section: Introductionmentioning

confidence: 99%

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Altered Serum Levels of Brain-Derived Neurotrophic Factor in Patients with Pathological Gambling

Geisel

Banas²,

Hellweg³

et al. 2012

Eur Addict Res

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Background: Brain-derived neurotrophic factor (BDNF) plays important roles in neurotransmitter release and synaptic plasticity and has been hypothesized to be involved in the development and maintenance of addictive disorders. The objective of this study was to investigate alterations of BDNF expression in a non-substance-related addiction, i.e. pathological gambling (PG). Methods: Serum levels of BDNF were assessed in male patients with PG (n = 14) and healthy control subjects (n = 13) carefully matched for sex, age, body mass index, smoking status and urbanicity. Symptoms and severity of PG were measured by the adapted form of the Yale-Brown Obsessive-Compulsive Scale. Results: BDNF serum levels were significantly increased in patients with PG in comparison to healthy control subjects (p = 0.016). There were no significant correlations between BDNF serum levels and severity of PG or clinical and demographic variables. Conclusions: Our results show alterations of BDNF serum levels in patients suffering from a behavioural addiction and suggest that non-substance-related addictions like PG might be associated with neuroendocrinological changes similar to the changes observed in substance-related addictions.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Altered Serum Levels of Brain-Derived Neurotrophic Factor in Patients with Pathological Gambling

Geisel

Banas²,

Hellweg³

et al. 2012

Eur Addict Res

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“…Neurotrophins are particularly important in many aspects of brain cells' development, nutrition, growth and survival [12][13][14]. Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are the best known neurotrophins and they were reported to be involved in the pathogenesis of alcohol dependence [14] and toxicity (16). NGF and also BDNF have also a role in regulating stress related events [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Serum BDNF and NGF Modulation by Olive Polyphenols in Alcoholics during Withdrawal

Carito¹

2015

J Alcohol Drug Depend

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Many studies have suggested possible relationships between the neurotrophins brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) and alcohol addiction. Previous reports demonstrated severe changes in these neurotrophins in the serum of alcohol dependent patients and during withdrawal. Alcohol dependence syndromes during consumption and/or withdrawal are also characterized by elevated oxidative stress. Polyphenols, including olive polyphenols, are natural compounds known to possess marked antioxidant properties. Thus, this study was carried out in order to verify the effects of a blend of olive polyphenols supplementation containing mostly hydroxytyrosol (50 mg/day for 15 consecutive days) in alcoholic men during withdrawal on serum BDNF and NGF. As controls a group of alcohol dependent patients received sucrose tablets as placebo. BDNF and NGF were measured by ELISA on day 1, 3, 7 and 15 of the detoxification period. Some parameters of oxidative stress were analyzed too as free oxygen radicals defense (FORD) and free oxygen radicals test (FORT). No differences in oxidative status due to polyphenols were found. However, withdrawal elicited a mild increase in BDNF over two weeks that was counteracted on day 3 by polyphenols. As for NGF no effects of polyphenols supplementation were discovered to antagonize the expected NGF serum elevation during withdrawal. In conclusion the present data may indicate that monitoring serum BDNF and/or NGF in alcoholics undergoing detoxification could contribute to characterize alcohol dependence profiles to improve recovery processes throughout also antioxidant compounds.

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Neurotrophic Factors and Ethanol Neurotoxicity

Davis¹

2014

Handbook of Neurotoxicity

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Relation between plasma brain-derived neurotrophic factor and nerve growth factor in the male patients with alcohol dependence

Cited by 52 publications

References 25 publications

Altered Serum Levels of Brain-Derived Neurotrophic Factor in Patients with Pathological Gambling

Altered Serum Levels of Brain-Derived Neurotrophic Factor in Patients with Pathological Gambling

Serum BDNF and NGF Modulation by Olive Polyphenols in Alcoholics during Withdrawal

Neurotrophic Factors and Ethanol Neurotoxicity

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