Relation between particle size and repose angles of powders

Carstensen, J.T.; Chan, Ping-Ching

doi:10.1016/0032-5910(76)80037-x

Cited by 48 publications

(26 citation statements)

References 8 publications

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“…Properties of the API, such as small particle size [8, 9] and needle-like morphology [10, 11] can lead to processing limitations such as poor flowability [12], difficulties with blending [9] as well as undesirable adhesion [13] to surfaces such as tablet punches or feeder walls [14]. These issues are addressed by selecting an appropriate processing route and/or by adding agents like glidants, lubricants or surfactants [15–18].…”

Section: Introductionmentioning

confidence: 99%

A Review of Disintegration Mechanisms and Measurement Techniques

2017

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Pharmaceutical solid dosage forms (tablets or capsules) are the predominant form to administer active pharmaceutical ingredients (APIs) to the patient. Tablets are typically powder compacts consisting of several different excipients in addition to the API. Excipients are added to a formulation in order to achieve the desired fill weight of a dosage form, to improve the processability or to affect the drug release behaviour in the body. These complex porous systems undergo different mechanisms when they come in contact with physiological fluids. The performance of a drug is primarily influenced by the disintegration and dissolution behaviour of the powder compact. The disintegration process is specifically critical for immediate-release dosage forms. Its mechanisms and the factors impacting disintegration are discussed and methods used to study the disintegration in-situ are presented. This review further summarises mathematical models used to simulate disintegration phenomena and to predict drug release kinetics.

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Section: Introductionmentioning

confidence: 99%

A Review of Disintegration Mechanisms and Measurement Techniques

2017

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“…The particle size and density affect the angle of repose, as well. It has been seen that increasing the particle size decreases the angle of repose [32]. In the present study, since the particle size and density have been fixed previously, therefore the coefficients of the rolling and static frictions (particle-particle and particle-wall) have been calibrated based on the angle of repose value.…”

Section: Calibration Of Dem Input Parametersmentioning

confidence: 97%

Analyzing the Mixing Dynamics of an Industrial Batch Bin Blender via Discrete Element Modeling Method

et al. 2017

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A discrete element model (DEM) has been developed for an industrial batch bin blender in which three different types of materials are mixed. The mixing dynamics have been evaluated from a model-based study with respect to the blend critical quality attributes (CQAs) which are relative standard deviation (RSD) and segregation intensity. In the actual industrial setup, a sensor mounted on the blender lid is used to determine the blend composition in this region. A model-based analysis has been used to understand the mixing efficiency in the other zones inside the blender and to determine if the data obtained near the blender-lid region are able to provide a good representation of the overall blend quality. Sub-optimal mixing zones have been identified and other potential sampling locations have been investigated in order to obtain a good approximation of the blend variability. The model has been used to study how the mixing efficiency can be improved by varying the key processing parameters, i.e., blender RPM/speed, fill level/volume and loading order. Both segregation intensity and RSD reduce at a lower fill level and higher blender RPM and are a function of the mixing time. This work demonstrates the use of a model-based approach to improve process knowledge regarding a pharmaceutical mixing process. The model can be used to acquire qualitative information about the influence of different critical process parameters and equipment geometry on the mixing dynamics.

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“…Carstensen and Chan (1976) and Zhou et al (2002) (blue circles). Grains may be bonded together either during their formation (such as occurs in rock) or by a secondary cement that forms between grains of unconsolidated materials.…”

Section: Shear Strengthmentioning

confidence: 99%