Relation Between Neutrophil-to-Lymphocyte Ratio and Index of Microcirculatory Resistance in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Lee, Man−Jong; Park, Sang‐Don; Kwon, Sung Woo; Woo, Seong‐Ill; Lee, Myung-Dong; Shin, Sung‐Hee; Kim, Dae Hyeok; Kwan, Jun; Park, Keum-Soo

doi:10.1016/j.amjcard.2016.07.072

Cited by 31 publications

(30 citation statements)

References 30 publications

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“…Our findings showing that parameter values change over the course of pregnancy do not conflict with the many reports that women’s immunological and cardiovascular systems undergo a large burden when they become pregnant 17 – 19 . The changes in parameter values observed as pregnancy proceeds (higher NLR and PLR and lower LMR) have been associated with higher inflammation and have been reported to reflect myocardial damage and microcirculatory resistance in patients with cardiovascular diseases 10 . This may be consistent with the fact that major pregnancy complications, including IPD, tend to occur later in pregnancy as well.…”

Section: Discussionmentioning

confidence: 99%

“…Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) are three biomarkers predictive of systemic inflammation which have recently gained interest, as they are widely available markers which can be calculated from simple blood counts and show prognostic significance for several diseases related to chronic low-grade inflammation, including cardiovascular diseases 10 , 11 and malignancies 12 – 14 . However, in the field of obstetrics, research concerning their natural course over the pregnancy period, as well as their predictive values for pregnancy outcomes during pregnancy has been scarce.…”

Section: Introductionmentioning

confidence: 99%

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Maternal blood count parameters of chronic inflammation by gestational age and their associations with risk of preterm delivery in the Japan Environment and Children’s Study

Morisaki

Piedvache

Nagata

et al. 2021

Sci Rep

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Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR), are three reportedly predictive biomarkers that reflect subclinical chronic inflammatory burden. However, how these biomarkers change during pregnancy and its clinical utility among pregnant women have been rarely studied. Among 76,853 singleton pregnancies delivered at 28–41 weeks of gestation that were enrolled in the Japan Environment and Children’s Study, we observed the distribution of maternal NLR, PLR, and LMR values from week 0 to week 36 using spline curves, as well as their predictive values for preterm delivery with and without hypertensive disorders in pregnancy, placental abruption and intrauterine growth restriction (collectively termed ischemic placental disease due to their shared pathological and pathophysiological features) for measurements at 8–11 weeks, 12–17 weeks, and 18–21 weeks. NLR and PLR increased, whereas LMR decreased, with increasing gestation. High LMR and low NLR observed at 18–21 weeks, but not at earlier gestations, were associated with higher risk of preterm delivery with IPD (odds ratio 1.80 [95% CI 1.02, 3.19] per log[LMR]; odds ratio 0.49 [95% CI 0.29, 0.82] per log[NLR]). All parameters were not predictive of preterm delivery without IPD. We provide a robust reference curve for maternal blood count parameters NLR, PLR, and LMR by gestational week.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Maternal blood count parameters of chronic inflammation by gestational age and their associations with risk of preterm delivery in the Japan Environment and Children’s Study

Morisaki

Piedvache

Nagata

et al. 2021

Sci Rep

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“…Nunez et al reported that low lymphocyte count was associated with the increased risk of myocardial infarction or death through the analysis in 1030 patients [32]. In addition, low lymphocyte was found to be reflective of impaired coronary microcirculation which had been validated as a relevant pathogenetic mechanism for CAD [33, 34]. High monocytes and low lymphocytes were confirmed to be independent risk indicators of cardiovascular diseases [16].…”

Section: Discussionmentioning

confidence: 99%

Monocyte/lymphocyte ratio predicts the severity of coronary artery disease: a syntax score assessment

Fan

et al. 2017

BMC Cardiovasc Disord

123

100

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BackgroundWe aimed to explore whether monocyte to lymphocyte ratio (MLR) provides predictive value of the lesion severity in patients with coronary artery disease (CAD).MethodsFive hundred forty-three patients undergoing coronary angiography were analyzed in this retrospective study. Patients with coronary stenosis were divided into three groups on the basis of Syntax score. The control group consisted of patients with normal coronary arteries. MLR was calculated by dividing monocytes count by lymphocytes count obtained from routine blood examination. Multivariate logistic analysis was used to assess risk factors of CAD. Ordinal logistic regression analysis was used to assess the relationship between MLR and the lesion severity of coronary arteries.ResultsMLR was found to be an independent risk factor of the presence of CAD (OR: 3.94, 95% CI: 1.20–12.95) and a predictor of the lesion severity (OR: 2.05, 95% CI: 1.15–3.66). Besides, MLR was positively correlated with Syntax score(r = 0.437, p < 0.001). In the receiver-operating characteristic (ROC) curve analysis, MLR, with an optimal cut-off value of 0.25, predicted the severe coronary lesion with a sensitivity of 60.26% and specificity of 78.49%.ConclusionsMLR was an independent risk factor of the presence of CAD, and a predictor of the lesion severity. Compared to neutrophil to lymphocyte ratio (NLR), MLR has better performance to reflect the severity of coronary lesion.

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“…The ratio of monocytes to lymphocytes defined in peripheral blood has been associated with the outcome of several diseases; including several types of cancer 1,2 , coronary heart disease 3 , Hepatitis B 4 , HIV 5 and Tuberculosis (TB) 5,6 , among others. In cases of cancer, it has been found that a chronic inflammatory situation, characterised by a high M:L is predictive of treatment failure and advancement of disease 2 .…”

Section: Introductionmentioning

confidence: 99%

Differences in monocyte: lymphocyte ratio and Tuberculosis disease progression in genetically distinct populations of macaques

Sibley

Gooch

Wareham

et al. 2019

Sci Rep

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Monocyte:lymphocyte ratio (M:L) has been identified as a risk factor in development of TB disease in children and those undergoing treatment for HIV in co-infected individuals. Retrospective analysis was performed using M:L data collected from TB modelling studies performed in Rhesus macaques of Indian genotype (RM), cynomolgus macaque of Chinese genotype (CCM) and cynomolgus macaque of Mauritian genotype (MCM), which found that the more susceptible populations (RM and MCM) had higher M:L ratios than the least susceptible population (CCM). Following Mycobacterium tuberculosis exposure, significant increases in M:L ratio were observed in susceptible RM and MCM within 12 weeks of TB infection, whereas M:L in CCM remained stable, suggesting that changes in M:L ratio may also act as a biomarker of TB disease progression. The frequency of PPD-specific interferon gamma (IFNγ) secreting cells (SFU) were compared, with the more susceptible macaque populations showing an association between M:L and IFNγ SFU frequency. Investigation of the genes associated with monocyte-derived antigen presenting cells revealed differences between RM and CCM, highlighting differences in their monocyte populations, as well as overall M:L ratio. Differences in M:L ratio between macaque populations could be used to explore immunological mechanisms in susceptible populations that would complement human population studies.

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Relation Between Neutrophil-to-Lymphocyte Ratio and Index of Microcirculatory Resistance in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Cited by 31 publications

References 30 publications

Maternal blood count parameters of chronic inflammation by gestational age and their associations with risk of preterm delivery in the Japan Environment and Children’s Study

Maternal blood count parameters of chronic inflammation by gestational age and their associations with risk of preterm delivery in the Japan Environment and Children’s Study

Monocyte/lymphocyte ratio predicts the severity of coronary artery disease: a syntax score assessment

Differences in monocyte: lymphocyte ratio and Tuberculosis disease progression in genetically distinct populations of macaques

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