Relation between Maternal Body Composition and Birth Weight

Aguirre, Luz Helena Sanín; Reza-López, Sandra A.; Levario-Carrillo, Margarita

doi:10.1159/000077586

Cited by 47 publications

(50 citation statements)

References 22 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results are in accordance with previous studies where maternal FFM was found to be positively related to infant birth weight (91)(92)(93). The findings in this thesis contribute additional knowledge, since it was demonstrated that it was the FFM of infants, rather than the FM, that is related to maternal FFM.…”

Section: Parental Body Composition Versus Infant Size and Body Compossupporting

confidence: 92%

“…The findings in this thesis contribute additional knowledge, since it was demonstrated that it was the FFM of infants, rather than the FM, that is related to maternal FFM. Given the present results, it is possible that the reported positive association between maternal BMI and infant birth weight (91)(92)(93) may to a large extent be due to an effect of the FFM rather than the FM of the mother. Further, Starling et al found that maternal BMI was associated with both infant FM and FFM (19).…”

Section: Parental Body Composition Versus Infant Size and Body Composmentioning

confidence: 66%

See 1 more Smart Citation

Body composition of parents and their infants : methodological, anthropometric, metabolic and genetic studies

Henriksson¹

2015

Linköping University Medical Dissertations

View full text Add to dashboard Cite

Body composition in infancy may be of importance for later health. In particular, infant body composition may be relevant regarding obesity risk in childhood. Recent advances in body composition methodology using air displacement plethysmography (ADP) have provided possibilities to accurately measure body composition of infants in a quick and non-invasive manner. The aims of this thesis were to study associations of parental body composition using ADP, glucose homeostasis during pregnancy and infant genetics with infant body composition also using ADP. When using ADP in adults, a correction for the thoracic gas volume (TGV) is needed and TGV can be predicted using equations developed in nonpregnant adults. Thus another aim was to study the validity of using such equations during pregnancy. Parent couples were invited to this study at a routine visit to a maternity clinic in Linköping between September 2008 and October 2010. When the mother was in gestational week 32, parental body composition using ADP and maternal glucose homeostasis variables were assessed. Size and body composition of healthy, singleton and full term (≥ 37 gestational weeks) infants were measured at 1 and 12 weeks of age and a total of 211 infants were included in the studies. Weight and length at 1 year of age were reported by parents. Saliva samples were collected from the infants to obtain DNA for genotyping of the fat mass and obesity associated (FTO) gene. Body composition results calculated using measured and predicted TGV were compared in 27 women. Results showed that predicted TGV yields a very marginal overestimation (0.5 %) of fat mass (FM). Further, each kg increase in maternal and paternal fat-free mass (FFM) was associated with 15.6 g (P=0.001) and 9.1 g (P=0.007), respectively, more FFM in their 1-week old infants. FM of fathers was not related to infant FM. However, maternal FM was positively associated with FM of daughters (5.8 g/kg, P=0.007), but not of sons (P=0.79) at 1 week of age. Similarly, each standard deviation increase in maternal HOMA-IR (homeostatic model assessment-insulin resistance) was related to 52.7 more g of FM (P<0.001) in 1-weekold daughters, but no such relationship was found for sons (P=0.79). The number of risk alleles at the FTO locus rs9939609 was not associated with infant body mass index (BMI) or infant FM at 1 or 12 weeks of age. However, the number of risk alleles was positively associated (P≤0.033) with infant length at 1 and 12 weeks of age, and the results suggested that this association was stronger in boys than in girls. The results presented in this thesis show that: i) The use of predicted TGV when applying ADP in gestational week 32 overestimated % FM only slightly. ii) Associations between parental and infant body composition are present early in life. Thus, parental FFM was positively related to FFM in 1-week-old infants. Furthermore, maternal FM and insulin resistance (HOMA-IR) were positively related to FM of 1-week-old daughters, but no such relationships were observed for sons. ii...

show abstract

Section: Parental Body Composition Versus Infant Size and Body Compossupporting

confidence: 92%

Section: Parental Body Composition Versus Infant Size and Body Composmentioning

confidence: 66%

Body composition of parents and their infants : methodological, anthropometric, metabolic and genetic studies

Henriksson¹

2015

Linköping University Medical Dissertations

View full text Add to dashboard Cite

show abstract

“…Some authors try to close this gap by deriving their own reference values [3] , but do not use different test and training datasets, which biases results. In addition, maternal height and weight should be considered when defining growth retardation in the offspring [13,14] .…”

Section: Discussionmentioning

confidence: 99%

The Search for Objective Criteria at the Limit of Viability

Bartels

Poets²

2007

Neonatology

View full text Add to dashboard Cite

Background: Defining the limit of viability among very preterm infants remains a difficult issue. A recent study suggested severity of intrauterine growth retardation as a decisive criterion, reporting very poor survival for infants born at ≤28 weeks with birth weight <2nd centile. Objective: To check whether the above criterion can be confirmed in a similar analysis of German data. Methods: Analyses were based on German population-based data from Lower Saxony, including preterm neonates (22–28 weeks) without severe congenital malformations (n = 3,453), born 1991–1999. For the definition of growth retardation postnatal (<3rd, <10th centile) and antenatal (<3rd centile) reference values were used. Results: Depending on the definition used, proportions of growth retarded infants varied considerably (4–16%). Survival rates increased from 0 to 64%, arguing against considering infants <28 weeks’ GA as a homogenous group with regard to their odds for survival. Conclusion: There is an association between severity of growth retardation and VLBW mortality in general, but overinterpreting results from single studies may lead to dangerous conclusions. Data from preterm infants should be stratified by week of gestation.

show abstract

“…However, associations persist in studies that have used net gestational weight gain (i.e. birth weight subtracted from total weight gain) as an exposure [76] . In addition, it is possible that shared genes underlie greater maternal and fetal weight gain.…”

Section: Gestational Weight Gain and Infant Health Fetal Growthmentioning

confidence: 99%

Weight Gain during Pregnancy: Importance for Maternal and Child Health

Herring

Oken

2010

Ann Nestlé [Engl]

View full text Add to dashboard Cite

Gestational weight gain is a strong predictor of short- and long-term health outcomes for both childbearing women and their offspring. Epidemiologic studies have found that higher maternal gestational weight gains are associated with abnormalities in maternal prenatal glycemia, hypertensive disorders of pregnancy and delivery complications, along with an increased risk of postpartum weight retention, incident obesity and adverse cardiometabolic sequelae in mothers by midlife. Additionally, observational data have linked greater gestational weight gains to increased fetal growth and later childhood obesity. Associations of gestational weight gain with preterm birth and infant mortality may be U-shaped, such that the risks are increased with both low and high gains. In an attempt to optimize both maternal and child outcomes, the Institute of Medicine revised gestational weight gain guidelines in 2009, recommending smaller gains for women with higher prepregnancy body mass indices, particularly for women entering pregnancy with a body mass index of at least 30. However, it is as of yet unclear if these new recommendations will lead to improvements in the proportions of women gaining recommended amounts, and in maternal and child health. As fewer than one third of mothers currently gain within the ranges recommended by the Institute of Medicine, interventions to help mothers achieve healthy gestational weight gains are of critical public health importance.

show abstract

Relation between Maternal Body Composition and Birth Weight

Cited by 47 publications

References 22 publications

Body composition of parents and their infants : methodological, anthropometric, metabolic and genetic studies

Body composition of parents and their infants : methodological, anthropometric, metabolic and genetic studies

The Search for Objective Criteria at the Limit of Viability

Weight Gain during Pregnancy: Importance for Maternal and Child Health

Contact Info

Product

Resources

About