Relation between male obesity and male infertility in a Tunisian population

Loukil, L. Hadjkacem; Hadj-Kacem, Hassen; Bahloul, Ali; Ayadi, Hammadi

doi:10.1111/and.12257

Cited by 21 publications

(14 citation statements)

References 24 publications

(32 reference statements)

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“…There are also studies reporting the negative effect of obesity on motility and ejaculate volume [ 16 , 17 ]. In a study similar to ours, where the infertility-associated risk factors were excluded, the sperm concentration was found to be negatively correlated with increased BMI [ 10 , 18 ] but we did not detect any such correlation in our study.…”

Section: Discussionmentioning

confidence: 99%

The impact of body mass index on reproductive hormones, testosterone/estradiol ratio and semen parameters

Öztekin

Caniklioğlu

Sarı

et al. 2020

Cent european J Urol

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Introduction The aim of this study was to evaluate the relationship between body mass index (BMI) and sperm parameters and reproductive hormone levels in patients with no known risk factors for infertility. Material and methods Four hundred patients who met the study’s inclusion criteria were divided into three groups according to their BMI values as normal weight (BMI: 18.5–24.9 kg/m 2 ), overweight (BMI 25–29.9 kg/m 2 ), and obese (BMI ≥30 kg/m 2 ). Semen parameters, reproductive hormone levels and testosterone/estradiol ratio were compared retrospectively between the groups. Results There was no significant difference between the groups in terms of age and infertility period. The mean BMI of all the patients was 26.6 ±4.08, and the BMI in the normal, overweight and obese groups were 22.6 ±1.7, 27.4 ±1.3, and 33.4 ±2.9, respectively (p <0.001). There was no significant difference between the groups in terms of serum follicle stimulating hormone, luteinizing hormone, estradiol, prolactin, semen volume, sperm concentration, total sperm count, and progressive and total motility. Serum testosterone (T) level and testosterone/estradiol (T/E2) ratio were significantly higher in the normal BMI group (p <0.001). Conclusions Adipose tissue increase was not significantly correlated with change in the semen parameters and it was negatively correlated with T levels and T/E2 ratio.

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Section: Discussionmentioning

confidence: 99%

The impact of body mass index on reproductive hormones, testosterone/estradiol ratio and semen parameters

Öztekin

Caniklioğlu

Sarı

et al. 2020

Cent european J Urol

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“…Research articles on humans published in English from 1965 to 2015 were included in this report [23][24][25][26][27][28][29][30][31][32][33][34][35][36] (Table 1). .…”

Section: Data Extraction and Data Anaysismentioning

confidence: 99%

Evidence for decreasing sperm count in African population from 1965 to 2015

Sengupta¹,

Nwagha²,

Dutta³

et al. 2017

Afr H. Sci.

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Purpose: This meta-analysis, following our previous reports those documented an overall 57% diminution in mean sperm concentration around the globe over past 35 years and 32.5% decline in past 50 years in European population, attempts to report the declining trend of sperm concentrations in African population between 1965 and 2015. Methods: In the course of retrieval of data following MOOSE guidelines and PRISMA checklist, we found a total of fourteen studies that have been conducted during that period on altering sperm concentration in the African male. Results: Following analysis of the data, a time-dependent decline of sperm concentration (r = -0.597, p = 0.02) and an overall 72.6% decrease in mean sperm concentration was noted in the past 50 years. The major matter of concern is the present mean concentration (20.38×10 6 /ml) is very near to WHO cut-off value of 2010 of 15×10 6 /ml. Several epidemic diseases, genital tract infection, pesticides and heavy metal toxicity, regular consumption of tobacco and alcohol are reported as predominant causative factors. Conclusion: This comprehensive, evidence-based meta-analysis and systematic review concisely presents the evidence of decreased sperm concentration in the African male over past 50 years with possible causative factors to serve the scientific research zone related to male reproductive health.

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“…The result from several studies suggested that obesity was an important risk factor for non-alcoholic fatty liver disease [4], hypertension [5], inflammation [6] and cancer [7]. Interestingly, data suggested obesity has a negative impact on male reproductive system and fertility over the past decade [8,9,10,11].…”

Section: Introductionmentioning

confidence: 99%

Soy Isoflavones Improve the Spermatogenic Defects in Diet-Induced Obesity Rats through Nrf2/HO-1 Pathway

Luo

Huang

et al. 2019

Molecules

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Soy isoflavones (SIF) are biologically active compounds of non-steroidal and phenolic properties that are richly present in soybeans, which can reduce the body weight and blood lipids of obese animals. Recently, SIF have been reported to affect reproductive ability in obese male rats. However, the specific mechanism has not been well defined. The aim of the current study was to study the possible mechanisms for the effect of SIF administration on obesity induced spermatogenic defects. Obese rats model induced by high-fat diets were established and gavage treated with 0, 50,150 or 450 mg of SIF/kg body weight/day for 4 weeks. Here, our research shows that obesity resulted in spermatogenic degeneration, imbalance of reproductive hormone, testicular oxidative stress and germ cell apoptosis, whereas evidently recovery effects were observed at 150 and 450 mg/kg SIF. We also have discovered that 150 and 450 mg/kg SIF can activate Nrf2/HO-1 pathway in control of Bcl-2, BAX and cleaved caspase-3 expression with implications in antioxidant protection. Our study indicates the potential mechanism of SIF regulating spermatogenic function in obese rats, and provides a scientific experimental basis for the regulation of biological function of obese male reproductive system by SIF.

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Relation between male obesity and male infertility in a Tunisian population

Cited by 21 publications

References 24 publications

The impact of body mass index on reproductive hormones, testosterone/estradiol ratio and semen parameters

The impact of body mass index on reproductive hormones, testosterone/estradiol ratio and semen parameters

Evidence for decreasing sperm count in African population from 1965 to 2015

Soy Isoflavones Improve the Spermatogenic Defects in Diet-Induced Obesity Rats through Nrf2/HO-1 Pathway

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