Relation Between Lung Function and RBC Distribution Width in a Population-Based Study*

Grant, Brydon J. B.; Kudalkar, Deepa; Muti, Paola; McCann, Susan E.; Trevisan, Maurizio; Freudenheim, Jo L.; Schünemann, Holger J.

doi:10.1378/chest.124.2.494

Cited by 77 publications

(57 citation statements)

References 22 publications

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“…[31][32][33] In the case of venous thrombosis, we hypothesize that a greater heterogeneity in cell size (and maybe lower erythrocyte deformability and higher aggregation) could increase viscosity and impair blood flow, leading to stasis, one of the main risk factors for venous thrombosis. This is supported by a recent study that showed that an increase in erythrocyte aggregation promotes thrombosis in femoral veins in a rabbit model.…”

Section: Discussionmentioning

confidence: 99%

Hematologic variables and venous thrombosis: red cell distribution width and blood monocyte count are associated with an increased risk

Rezende¹,

Lijfering²,

Rosendaal³

et al. 2013

Haematologica

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Odds ratios and their 95% confidence intervals (95% CI) were cal- open-access paper. doi:10.3324/haematol.2013 Recent studies suggest that leukocytes and erythrocytes play a role in coagulation. However, whether leukocytes, erythrocytes and other hematologic variables are associated with risk of venous thrombosis is not well known. To study this, we used data from 2473 patients with venous thrombosis and 2935 controls. The variables assessed were: total leukocytes, granulocytes, lymphocytes, monocytes, hematocrit, hemoglobin, erythrocytes and red cell indices (mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration and red cell distribution width). We found a strong dose-response relation for higher red cell distribution width and monocyte count with risk of venous thrombosis, with odds ratios of 3.1 (95% confidence interval, 2.0-4.8) and 2.8 (95% confidence interval, 1.3-5.8), respectively, after adjustment for age, sex, C-reactive protein level, malignancy and co-morbidities. Monocyte count and red cell distribution width were associated with venous thrombosis even within reference ranges. A low monocyte count (<0.12x10 9 /L) was associated with a lower risk of venous thrombosis after full adjustment (odds ratios 0.6; 95% confidence interval, 0.4-0.8). In summary, high red cell distribution width and blood monocyte count, two parameters that are inexpensive and easily obtainable, were clearly associated with an increased risk of venous thrombosis. Future studies should evaluate the underlying mechanism and the use of these variables in prediction models for first and recurrent thrombosis. ©2013 Ferrata Storti Foundation. This is an Hematologic variables and venous thrombosis: red cell distribution width and blood monocyte count are associated with an increased risk

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Section: Discussionmentioning

confidence: 99%

Hematologic variables and venous thrombosis: red cell distribution width and blood monocyte count are associated with an increased risk

Rezende¹,

Lijfering²,

Rosendaal³

et al. 2013

Haematologica

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“…There is mounting evidence linking elevated RDW and adverse outcomes in cardiac disease (2)(3)(4), pulmonary embolism (5), trauma (6), septic shock (7), acute pancreatitis (8), hepatitis (9), stroke (10), dementia (11), metabolic syndrome (12), and respiratory diseases such as non-small cell lung cancer (NSCLC) (13,14), chronic obstructive pulmonary disease (15), interstitial pneumonia (16) and sarcoidosis (17). High RDW has been associated with increased mortality and poor pulmonary function also in the general population (18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of red cell distribution width in elderly patients undergoing resection for non-small cell lung cancer

et al. 2016

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Background:The impact of red cell distribution width (RDW) on outcomes in elderly patients after surgery for non-small cell lung cancer (NSCLC) is not fully understood. Methods: We retrospectively analyzed 992 NSCLC patients who underwent curative resection between 1998 and 2012. The following variables were included in the analyses to evaluate the role of RDW: age, gender, smoking index, leukocyte count, neutrophil to lymphocyte ratio (NLR), hemoglobin, platelet count, albumin, C-reactive protein, carcinoembryonic antigen, respiratory function, histology, T factor, N factor, surgical approach, surgical procedures, complications and prognosis. Results: High RDW (>13.8) was an independent risk factor for morbidity [hazard ratio (HR) 2.1; P<0.01], recurrence (HR 2.0; P=0.01), overall survival (OS) (HR 2.1; P<0.01) and disease-free survival (DFS) (HR 2.0; P<0.01) in elderly patients (age ≥75 years, n=275), whereas it was not in younger patients (age <75 years, n=717). The surgical outcome was extremely poor in those older than 80 years with a RDW greater than 15% (morbidity, 56%; postoperative stay, 23 days; OS, 24%; DFS, 0%). RDW was unaffected by age (R =0.01; P=0.86) and elevated RDW without anemia was more prognostic than high RDW due to anemia in elderly patients. Conclusions: High RDW was significantly associated with high morbidity and reduced survival in elderly patients who underwent resection for NSCLC. Therefore, this parameter should be taken into account when surgery is considered in the elderly. investigation of the etiology of anemia (1). The volume of erythrocytes is consistent, and RDW is normal in the case of anemia caused by rapid bleeding, whereas the increase of relatively large reticulocytes during the recovery process of anemia raises RDW in the case of slowly progressing anemia. RDW has recently been reported to also be an inflammatory indicator. There is mounting evidence linking elevated RDW and adverse outcomes in cardiac disease (2-4), pulmonary embolism (5), trauma (6), septic shock (7), acute pancreatitis (8), hepatitis (9), stroke (10), dementia (11), metabolic syndrome (12), and respiratory diseases such as non-small cell lung cancer (NSCLC) (13,14), chronic obstructive pulmonary disease (15), interstitial pneumonia (16) and sarcoidosis (17). High RDW has been associated with increased mortality and poor pulmonary function also in the general population (18)(19)(20).The aim of this study was to investigate the prognostic impact of RDW on outcomes in elderly patients after surgery for NSCLC. Methods Patient cohortA total of 1,061 patients with NSCLC who underwent resection at our institute between 1998 and 2012 were retrospectively analyzed. Before the study, the Research Review Board of Tokyo University examined and approved our research protocol in accordance with the Declaration of Helsinki (project approval No. 2406). All patients undergoing surgery irrespective of this study provided written informed consent for the review of their medical charts before the surgery. A total of 69...

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“…Grant et al [4] evaluated an inverse relationship between lung function and RDW in a population-based study.…”

Section: Introductionmentioning

confidence: 99%

Medical significance of simultaneous application of red blood cell distribution width (RDW) and neopterin as diagnostic/prognostic biomarkers in clinical practice

Zvetkova

Fuchs²

2017

Pteridines

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In our individual and collaborative studies, we have played a part in pioneering investigations on the usefulness of biomarkers -red blood cell distribution width (RDW) and neopterin. This mini review includes historical data on the topic and is related to the first contributions in this field, as well as to the possibilities for further improvement and simultaneous application of RDW and neopterin measurements in the prevention, prognosis and treatment of a great number of socially important disease conditions (arterial, cardiovascular, brain vascular, peripheral artery diseases, inflammations, autoimmune states, cancers and leukemias, addictions, etc.). When comparing the results obtained with the immunobiochemical biomarker neopterin with RDW, they are reported to be very similar as independent predictors of the same pathological states in the human body although their biomedical origins are very different. Both the parameters were until now successfully, but only separately used in medical practice. The combined use of these two biomarkers can shed some more light on their interrelationships and provide some clues as to how the interaction between immune system activation and red blood cells biology are intertwined.

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Relation Between Lung Function and RBC Distribution Width in a Population-Based Study*

Cited by 77 publications

References 22 publications

Hematologic variables and venous thrombosis: red cell distribution width and blood monocyte count are associated with an increased risk

Hematologic variables and venous thrombosis: red cell distribution width and blood monocyte count are associated with an increased risk

Prognostic significance of red cell distribution width in elderly patients undergoing resection for non-small cell lung cancer

Medical significance of simultaneous application of red blood cell distribution width (RDW) and neopterin as diagnostic/prognostic biomarkers in clinical practice

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