Relation between lipoprotein subfractions and <scp>TSH</scp> levels in the cardiovascular risk among women with subclinical hypothyroidism

Hernández‐Mijares, Antonio; Jover, A; Bellod, Lorena; Bañuls, Celia; Solá, Eva; Veses, Silvia; Víctor, Víctor M.; Rocha, Milagros

doi:10.1111/cen.12064

Cited by 29 publications

(20 citation statements)

References 33 publications

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“…Regarding lipoproteins subclasses, Hernadez-Mijares found, similarly to the current study, increasing proportion of LDL pattern B profile patients from euthyroid to SCH(26). However, they did not address LDL subclasses across the euthyroidism range.…”

Section: Discussionsupporting

confidence: 88%

Impact of Subclinical Hypothyroidism on Cardiometabolic Biomarkers in Women

Harada

Buring

Cook

et al. 2017

Journal of the Endocrine Society

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Context:Whether subclinical hypothyroidism (SCH) is associated with cardiometabolic abnormalities is uncertain.Objective:To examine diverse cardiometabolic biomarkers across euthyroid, SCH, and overt hypothyroidism (HT) in women free of cardiovascular disease.Design:Cross-sectional adjusted associations for lipids, lipoprotein subclasses, lipoprotein insulin resistance score, inflammatory, coagulation, and glycemic biomarkers by analysis of covariance for thyroid categories or thyroid stimulating hormone (TSH) quintiles on a Women’s Health Study subcohort.Setting:Outpatient.Patients or Other Participants:Randomly sampled 3914 middle-aged and older women for thyroid function analysis (TSH, free T4), of whom 3321 were not on lipid-lowering therapy.Intervention:None.Main Outcome Measure:Associations of SCH and HT with cardiometabolic markers.Results:Going from euthyroid to HT, the lipoprotein subclass profiles were indicative of insulin resistance (respective values and P for trend): larger very-low-density lipoprotein size (nm) (51.5 [95% confidence interval (CI), 51.2, 51.8] to 52.9 [51.8, 54.1], P = 0.001); higher low-density lipoprotein (LDL) particle concentration (nmol/L) [1283 (95% CI, 1267, 1299) to 1358 (1298, 1418), P = 0.004], and smaller LDL size. There was worsening lipoprotein insulin resistance score from euthyroid (49.2; 95% CI, 48.3, 50.2) to SCH (52.1; 95% CI, 50.1, 54.0) and HT (52.1; 95% CI, 48.6, 55.6); P for trend of 0.008. Of the other biomarkers, SCH and HT were associated with higher high-sensitivity C-reactive protein and hemoglobin A1c. For increasing TSH quintiles, results were overall similar.Conclusions:In apparently healthy women, SCH cardiometabolic profiles indicated worsening insulin resistance and higher cardiovascular disease risk markers compared with euthyroid individuals, despite similar LDL and total cholesterol. These findings suggest that cardiometabolic risk may increase early in the progression toward SCH and overt HT.

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Section: Discussionsupporting

confidence: 88%

Impact of Subclinical Hypothyroidism on Cardiometabolic Biomarkers in Women

Harada

Buring

Cook

et al. 2017

Journal of the Endocrine Society

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“…However, a large cross-sectional study conducted in Australia, did not show any difference in the prevalence of hypertension or mean SBP/DBP values between euthyroid subjects or those with SH (23), as did a more recent study in Spain (24). Interestingly, even mild differences in serum TSH (within the reference range) have been associated with signif- icant differences in DBP (25), although others did not find any difference (26). The reduction in SBP and DBP observed in our study and its clinical implications need to be further confirmed in future studies.…”

Section: Discussionmentioning

confidence: 96%

The effect of L-thyroxine substitution on lipid profile, glucose homeostasis, inflammation and coagulation in patients with subclinical hypothyroidism

et al. 2014

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“…The studies have shown SCH to be associated with highly atherogenic pattern B of LDL-C subfractions. 26 It has been reported that as a marker of lipoprotein particle size, the value of LDL and VLDL adds predictive value beyond that of the individual lipids, and/or TC/HDL-C ratio. 27 This could also indicate that SCH is associated with high LDL & VLDL and thereby a highly atherogenic lipid profile.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Thyrotropin and Fasting Lipid Profile in Patients of Sub Clinical Hypothyroidism

Zubair

Ijaz²,

Aftab³

2017

Annals KEMU

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A controversy exists regarding the association between subclinical hypothyroidism (SCH) and dyslipidemia. Moreover, studies on lipid ratios in SCH are rare, particularly in Asian Countries. The study also aims to find out whether any correlation exists between serum TSH levels and fasting lipid levels, which would indirectly affect morbidity and mortality. Methods:The study was conducted at Physiology department, KEMU and Centre for Nuclear Studies KEMU & Mayo Hospital, Lahore which is a tertiarycare center. It was a cross-sectional study carried out over a period of 6 months. Control group consisted of 50 euthyroid persons taken from a population coming for whole-body health checkup. Case group consisted of 50 patients with SCH. Confounding variables were removed. Fasting blood samples were taken in a plain gel vaccutainer tube with an aseptic blood collection technique. The samples were centrifuged within 1 h at 3000 rpm for 5 min. These were 1 Assistant Professor of Physiology

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Relation between lipoprotein subfractions and TSH levels in the cardiovascular risk among women with subclinical hypothyroidism

Abstract: Our findings indicate that cardiovascular risk is affected in patients with TSH levels over 10 mIU/l, who have a lipid profile characteristic of atherogenic dyslipidemia.

Cited by 29 publications

References 33 publications

Impact of Subclinical Hypothyroidism on Cardiometabolic Biomarkers in Women

Impact of Subclinical Hypothyroidism on Cardiometabolic Biomarkers in Women

The effect of L-thyroxine substitution on lipid profile, glucose homeostasis, inflammation and coagulation in patients with subclinical hypothyroidism

Correlation between Thyrotropin and Fasting Lipid Profile in Patients of Sub Clinical Hypothyroidism

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