Relation Between Lipoprotein(a) and Fibrinogen and Serial Intravascular Ultrasound Plaque Progression in Left Main Coronary Arteries

Hartmann, Marc; Birgelen, Clemens von; Mintz, Gary S.; Stoel, Martin G.; Eggebrecht, Holger; Wieneke, Heinrich; Fahy, Martin; Neumann, Till; Palen, Job van der; Louwerenburg, Hans W.; Verhorst, Patrick M.J.; Erbel, Raimund

doi:10.1016/j.jacc.2006.03.047

Cited by 48 publications

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References 41 publications

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“…Until now, the association between fibrinogen and invivo coronary plaque characteristics has only been examined in two IVUS studies [17,18]. The first study had a modest study sample size of 60 patients and applied grayscale IVUS to quantify coronary atherosclerosis, which did not allow for assessment of the composition and vulnerability of the coronary plaques [17].…”

Section: Introductionmentioning

confidence: 99%

Fibrinogen in relation to degree and composition of coronary plaque on intravascular ultrasound in patients undergoing coronary angiography

Buljubasic

Akkerhuis

Cheng

et al. 2017

Coronary Artery Disease

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OBJECTIVE: The aim of this study was to provide additional insight into the role of fibrinogen in coronary artery disease by investigating the associations between plasma fibrinogen with both degree and composition of coronary atherosclerosis as determined by virtual histology-intravascular ultrasound. PATIENTS AND METHODS: In 581 patients undergoing coronary angiography for acute coronary syndrome (ACS) or stable angina pectoris, preprocedural blood samples were drawn for fibrinogen, Creactive protein (CRP), interleukin-6, and plasminogen activator inhibitor-1 measurements, and virtual histology-intravascular ultrasound of a nonculprit coronary artery was performed. The degree [plaque volume, plaque burden (PB), and lesions with PB70%] and the composition of coronary atherosclerotic plaque (fibrous, fibrofatty, dense calcium, necrotic core tissue, and thin-cap fibroatheroma lesions) were assessed. RESULTS: Fibrinogen showed a tendency toward a positive association with PB [ (95% CI): 2.55 (-0.52-5.61) increase in PB per ln(g/l) fibrinogen, P=0.09], which was driven significantly by an association in the ACS subgroup [ (95% CI): 4.11 (0.01-8.21) increase in PB per ln(g/l) fibrinogen, P=0.049]. Fibrinogen was also related to the presence of lesions with PB 70% or more in both the full cohort [OR (95% CI): 2.27 (1.17-4.43), P=0.016] and ACS patients [OR (95% CI): 2.92 (1.17-7.29), P=0.022]. All associations were independent of established cardiovascular risk factors, but not CRP. Interleukin-6 and plasminogen activator inhibitor-1 did not provide incremental value to fibrinogen when examining the associations with degree of atherosclerosis. Substantial associations with plaque composition were absent. CONCLUSION: Fibrinogen is associated with degree of coronary atherosclerosis, especially in ACS patients. However, whether this association is independent of CRP might be questioned and needs further investigation. Objective The aim of this study was to provide additional insight into the role of fibrinogen in coronary artery disease by investigating the associations between plasma fibrinogen with both degree and composition of coronary atherosclerosis as determined by virtual histologyintravascular ultrasound. Patients and methodsIn 581 patients undergoing coronary angiography for acute coronary syndrome (ACS) or stable angina pectoris, preprocedural blood samples were drawn for fibrinogen, C-reactive protein (CRP), interleukin-6, and plasminogen activator inhibitor-1 measurements, and virtual histology-intravascular ultrasound of a nonculprit coronary artery was performed. The degree [plaque volume, plaque burden (PB), and lesions with PB ≥ 70%] and the composition of coronary atherosclerotic plaque (fibrous, fibrofatty, dense calcium, necrotic core tissue, and thin-cap fibroatheroma lesions) were assessed.Results Fibrinogen showed a tendency toward a positive association with PB [β (95% CI): 2.55 (− 0.52-5.61) increase in PB per ln(g/l) fibrinogen, P = 0.09], which was driven significantly by an associat...

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Section: Introductionmentioning

confidence: 99%

Fibrinogen in relation to degree and composition of coronary plaque on intravascular ultrasound in patients undergoing coronary angiography

Buljubasic

Akkerhuis

Cheng

et al. 2017

Coronary Artery Disease

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“…According to retrospective studies exceeded levels of Lp (a) are connected with progress of atherosclerotic plaques in the coronary arteries, which never had stenosis before [13,14].…”

Section: Resultsmentioning

confidence: 99%

Features of Biochemical Parameters of Blood Serum in Patients with Stable Angina and Type 2 Diabetes Mellitus

Петелина¹

2018

EMIJ

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Background: The study of a wide panel of vascular inflammatory markers is required to clarify the nature of the relationship between the pathogenetic mechanisms of coronary artery disease (CAD) and type 2 diabetes mellitus. Aim:To conduct comparative analysis of lipid profile and markers of vascular inflammatory reaction in patients with CAD, stable angina, without and together with DM 2 type. Materials and methods:169 patients (males and females) aged 61.4±9.2 years with CAD and stable effort angina were studied. Patients were divided into two groups: group 1 (n=123) with CAD, group 2 CAD patients with DM 2 type (n=46). Study of blood plasma laboratory parameters was conducted in the groups of patients initially at the admission before coronary angiography. Results:In both groups of patients, the excess of the reference values of the lipid profile atherogenic parameters (TC, LDL, VLDL, TG) was detected. Significant excess of the level of vascular inflammation markers (hs-СRP, TNF -α, homocysteine, IL-1β) was registered along with the excess of normal values of MMP-9 and endothelin-1 in the group of patients with CAD with DM type 2 that could indicate more pronounced vascular inflammation in this group. Conclusion:Characteristic features for patients with CAD combined with DM type 2 are dyslipidemia with elevated total cholesterol (TC) level and low level of high-density lipoprotein cholesterol (HDL), along with hyperactivation of markers of vascular inflammatory response with a significantly higher level of hs-СRP, TNF-α, homocysteine and IL-1β compared to CAD patients without type 2 DM.

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“…According to retrospective studies exceeded levels of Note: n-amount of patients, p -significance of differences. Petelina Lp (a) are connected with progress of atherosclerotic plaques in the coronary arteries, which never had stenosis before [13,14].…”

Section: Resultsmentioning

confidence: 99%

Specific parameters of lipid spectrum and markers of vascular inflammation in patients with stable angina and significant coronary artery stenosis with or without diabetes mellitus type 2. A prospective follow-up after angioplasty

Petelina¹,

Musikhina²,

Гапон³

et al. 2017

Integr Obesity Diabetes

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Background: Despite intensive studies of atherosclerosis associated with DM, the mechanisms of the close relationship between diabetes and CAD are not yet fully indicated; as a result, the search and study of other causes, including vascular inflammatory processes, that accelerate and aggravate the development of atherosclerotic vascular lesions and complications is intensively continuing and that identify the relevance of the research problem. Aim:To perform comparative analysis of lipid profile and markers of vascular inflammatory reaction in patients with CAD and stable angina in general groups and identifying the subgroups with significant coronary artery stenosis without and with DM 2 type. To estimate biochemical parameters of blood serum prospectively after angioplasty in subgroups of patients with significant coronary artery stenosis. Materials and methods:97 patients (males and females) aged 60.3 ± 9.8 years with CAD and stable effort angina were studied. Patients were divided into two groups: group 1 (n=64) with CAD, group 2 (n=33) CAD patients with DM 2 type (n=33). According to selective coronary angiography patients in both groups had significant stenosis of one of the coronary arteries with the degree ≥75% of the vessel lumen. Patients with significant coronary artery stenosis in both subgroups underwent coronary angioplasty with the one-type stents with a drug coating. Study of blood plasma laboratory parameters was conducted in the groups of patients initially at the admission before coronary angiography and at the control points -3, 6 and 12 months after angioplasty and stenting. Duration of patients follow-up was 12 ± 1.2 years after angioplasty. Results:In both groups of patients, the excess of the reference values of the lipid profile atherogenic parameters (TC, LDL, VLDL, TG) was detected. Significant excess of the level of vascular inflammation markers (hs-СRP, TNF -α, homocysteine, IL-1β) was registered along with the excess of normal values of MMP-9 and endothelin-1 in the group of patients with CAD with DM type 2 that could indicate more pronounced vascular inflammation in this group. Prospective follow-up showed the maximum increased level of inflammatory markers at the control point "3 months" after angioplasty in both subgroups. In general, within the positive dynamics of the studied parameters, no attainments in target lipid levels (TC, HDL, TG) and markers of inflammation (HF-CRP, MMP-9) were found at the endpoint of follow-up "12 months" that could indicate the persistence of a systemic slow vascular inflammatory response. Conclusions:Systemic inflammatory response is more pronounced in CAD plus DM type 2 patients both in the general group and in a subgroup with significant coronary stenosis. Maximum level of activation of vascular inflammation parameters at the point "3 months" after angioplasty and persistence of a systemic slow vascular inflammatory response to the endpoint of follow-up determine the patients of both subgroups as patients of very high cardiovascular risk...

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Relation Between Lipoprotein(a) and Fibrinogen and Serial Intravascular Ultrasound Plaque Progression in Left Main Coronary Arteries

Cited by 48 publications

References 41 publications

Fibrinogen in relation to degree and composition of coronary plaque on intravascular ultrasound in patients undergoing coronary angiography

Fibrinogen in relation to degree and composition of coronary plaque on intravascular ultrasound in patients undergoing coronary angiography

Features of Biochemical Parameters of Blood Serum in Patients with Stable Angina and Type 2 Diabetes Mellitus

Specific parameters of lipid spectrum and markers of vascular inflammation in patients with stable angina and significant coronary artery stenosis with or without diabetes mellitus type 2. A prospective follow-up after angioplasty

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